DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hml and Fcgbp

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:NP_001158129.3 Gene:Fcgbp / 100303643 RGDID:2313189 Length:2583 Species:Rattus norvegicus


Alignment Length:3264 Identity:685/3264 - (20%)
Similarity:1029/3264 - (31%) Gaps:1215/3264 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   483 ALCTTWGGINMKTFDGLVFKAPLSCSHTLI----TDKVSGTFDIILKACPYGSG----------Y 533
            |:|...|..:..||||..:....|||:|:.    :|:....|.:..|....||.          |
  Rat    54 AVCRAQGDPHYTTFDGRRYDMMGSCSYTMAELCGSDETLPAFSVEAKNEHRGSRQVSYVGLVTVY 118

  Fly   534 GCAHTLKILWQSVLYTFENLNGTMQLTTPIKKLPMPVQVMGMKVMPVAQHVQIDLE-SVGLKLDW 597
            ..:|::.::        ....|.:::.....:||..:....::|........|:|: .:.:..||
  Rat   119 AYSHSVSMV--------RGETGFIRIDNQRSRLPASLSEGRLRVYQSGTRGIIELDFGLVISYDW 175

  Fly   598 DHRQYVSVQAGPQMW-GKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRSELCQ--V 659
            |.:..:|:   |:.: .:|.||||..:|||..|..:...::......||::|:::|...||.  .
  Rat   176 DSQLTLSL---PKRFQDQVCGLCGNYNGDPADDFLTPDLEQAPNALEFANSWKLDDGDYLCDDGC 237

  Fly   660 ENSAEMEFGMDSCEQSKLQ--KAVSVCERL-LANEKLGDCIKPFNYDALIRTCMADYCNCANREH 721
            .||.      .||...::|  |...:|..| |:......|.:..:....:..|:.|.|.....  
  Rat   238 HNSC------PSCTPGQMQHYKGDRLCGMLALSTGPFSACHELLDPKPFLEDCVFDLCVTGGE-- 294

  Fly   722 PESCNCDAIAMLAKECAFKGIKLEHGWRNLEICPISCGFGRVYQACGPNVEPTCDSDLALPA--S 784
             ....|.:::..|:.|...|:.||: ||....||:||.....|..|.|....:|:|: |||:  |
  Rat   295 -RLSLCRSLSAYAQACVELGVTLEN-WRQPSNCPMSCPANSCYDPCSPACPASCNSE-ALPSNCS 356

  Fly   785 KGACNEGCFCPEGTVQYKEACITRELCPCSLRGKEFKPESTV------KKNCNTC-------TCK 836
            ...|.|||.|..|.|.....|:....|.|:.:|:...|...|      ::.| ||       ||:
  Rat   357 SRPCVEGCVCLPGFVASGGDCVPVSSCGCTYQGRPLAPGQEVFADDQCQRRC-TCDGATQKVTCR 420

  Fly   837 --------------NGQWRCTEDKCGARCGAVGDPHYQTFDGKRYDFMGKCSYHLLKT--QNTSV 885
                          ||...|..|.. |.|.|.|||||.:|||||:||||.|:|.|:.:  ||.::
  Rat   421 DTSGCPSGEHCNVQNGLLGCYPDNF-ASCQASGDPHYVSFDGKRFDFMGTCTYLLVGSCGQNAAL 484

  Fly   886 EAENVACSGAVSESMNFAAPDDPSCTKAVTIRFILRDGTPSVIKLDQGLTTIVNDKPIAKLPKML 950
            .|..|........|...      |.|:||.   ::..|....::.:.....:| |..:..||...
  Rat   485 PAFKVLVENEHRGSQTV------SYTRAVR---VVAHGVEVAVRRENPGRVLV-DGVLQYLPFQA 539

  Fly   951 GLGEVLI-RRASSTFLTVEFADGIRVWWDGVSRVYIDAPPSLRGQTQGLCGTFNSNTQDDFLTPE 1014
            ..|:|.: |:.:...::.:|...:...||  :.|....|.|......||||.||.|..||.....
  Rat   540 AGGKVRVYRQGNDAVVSTDFGLTVTYNWD--AHVTAKVPNSYAKAVCGLCGNFNGNPDDDLALKG 602

  Fly  1015 GDVETAVEPFADKWRTKDTCQFKAETHQGPHPCTLNPE------KKAQAEKFCDWILQD---IFQ 1070
            |.....|..|.:.|:.:......|.|   |..|   |:      ::.|::|.|. ||.|   .|:
  Rat   603 GGQANNVLDFGNSWQEEIIPGCGATT---PGDC---PQLDSLVTQQTQSKKECG-ILADPEGPFR 660

  Fly  1071 DCHFLVEPEQFYEDCLYDTCACKDEMSKCFCPILSAYGTECMRQ-GVKTGWRMSVKECAVKCPLG 1134
            :||.|:.|:....||:||.|....: |...|..|:||..||... |....|| |.|.|.:.||..
  Rat   661 ECHKLLNPQGAIRDCVYDLCLLPGQ-SGPLCEALAAYAAECQAAGGTVHPWR-SEKLCPLTCPPN 723

  Fly  1135 QVFDECGDGCALSCDDLPSKGSCKRECVEGCRCPHGEYVNEDGE-CVPKKMCHCNFDGMSFRPGY 1198
            ..::.|..||.|||.|||..|.|..||.|.|.|..|..::  || |||...|.|.:.|....|| 
  Rat   724 SHYELCSYGCPLSCGDLPVPGGCGSECRESCVCDEGFALS--GESCVPLASCGCVYQGAYHSPG- 785

  Fly  1199 KEVRPGEKFLDLCTCTDGVWDCQDAEPGDKDKYPPSSELRSKCAKQPYAEFTKCAPKEPKTCKNM 1263
            :...||.....||.|.:|                                               
  Rat   786 ETFYPGPGCESLCHCEEG----------------------------------------------- 803

  Fly  1264 DKYVADSSDCLPGCVCMEGYVYDTSRLACVLPANCSCHHAGKSYDDGEKIKEDCNLCECRAGNWK 1328
                        |.|..|             |::|..|.|                |:...|...
  Rat   804 ------------GLVSCE-------------PSSCGPHEA----------------CQPSNGVLG 827

  Fly  1329 CSKNGCESTCSVWGDSHFTTFDGHDFDFQGACDYVLAK--GVFDNGDGFSITIQNVLCGTMGVTC 1391
            |...| .:||...||.|:.||||..|||.|.|.||||:  |.......|::..:|...|...|:.
  Rat   828 CVAVG-TTTCQASGDPHYITFDGRRFDFMGTCVYVLAQTCGTRPGLHQFTVLQENEPWGNGKVSV 891

  Fly  1392 SKSLEIALTGHAEESLLLSADSAYSTDPNKTPIK--------KLRDSVNSKGHNAFHIYKAGVFV 1448
            :|.:.:.:..:.    |....:.:....|...:|        |:|  |:..|.:|          
  Rat   892 TKVITVLVANYT----LRLEQNQWKVKVNGVDMKLPVVLDGGKIR--VSQHGSDA---------- 940

  Fly  1449 VVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPSMGLETSPMLFGHAWK 1513
            |:|. ...|:|.:|....|.|.:...:.|::.||||:|||:..||.|.|.....|:|..||::|:
  Rat   941 VIET-DFGLRVAYDLVYSVRVTIPGNYYQQMCGLCGDYNGDPKDDFQKPDGSQATNPSDFGNSWE 1004

  Fly  1514 LQPHCSAPVAPI---------DACKKHPERETWAQLKCGALKSDL--FKECHAEVPLERFWKRCI 1567
             :....:|.||:         .||....|.:...:..||.|.:..  ...||..:..:...|.|:
  Rat  1005 -EAVPDSPCAPVPPCTGDDCNPACSPELENKYSGEKFCGLLTNPTGPLAACHKLLDPQGPLKDCV 1068

  Fly  1568 FDTCACDQGGDCECLCTAVAAYADACAQKGINIR-WRSQHFCPMQCDPHCSDYKACTPACAV--- 1628
            ||.|.  .||:...||..:.||..||.:.|..:. ||::.||||:|.|| |.|:.|...|::   
  Rat  1069 FDLCL--GGGNQSILCNNIHAYVSACQEAGGQVEPWRTETFCPMKCPPH-SHYEVCADTCSLGCW 1130

  Fly  1629 -----ETCDNFLDQGIAERMCNRENCLEGCHIKPCEDGFIYLNDTYRDCVPKAECKPVCMVRDGK 1688
                 :.|.              |.|.|||.   |:.||:|   ..:.|||..||.  |      
  Rat  1131 ALSTPQKCP--------------EVCAEGCE---CDSGFLY---NGKACVPIQECG--C------ 1167

  Fly  1689 TFYEGDITFTDSCATCRCSKRKEICSGVKCDVPATTGLPAPLVEGTTLPTPLATQNQTKCVKGWT 1753
             ::.|                                                            
  Rat  1168 -YHNG------------------------------------------------------------ 1171

  Fly  1754 RWCDKDRDTSDKSVRLNDEEKVPRYDRMENVYGTCLKQYMTKVECRVKDTHEAPEQMDENVVCSL 1818
                         |....||.|    .:||....|:                             
  Rat  1172 -------------VYYEPEESV----LIENCQQHCV----------------------------- 1190

  Fly  1819 EEGLRCIGKCHDYELRAFCQCDEELEPELPKPTEKPQLGLACDAAVVEYKEFPGDCHKFLHCQPK 1883
                     ||                        |..|:.|.                      
  Rat  1191 ---------CH------------------------PGTGMVCQ---------------------- 1200

  Fly  1884 GVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGLKPEPEPEFEPIKQCPPGKIKSECA 1948
                                      ||                         .|.||::     
  Rat  1201 --------------------------DH-------------------------SCKPGEV----- 1209

  Fly  1949 NQCENTCHYYGSILKKRGLCQVGEHCKPGCVDELRPDCPKLGKFWRDEDTCVHADECPCMDKAEH 2013
                  |...|.:|                                   ||:..|.|        
  Rat  1210 ------CEPSGGVL-----------------------------------TCITKDPC-------- 1225

  Fly  2014 YVQPHKPVLGEFEVCQCIDNAFTCVPNKPEPVPKDEDDDLDLVSVVPIYPVTLTPPLQCSPERLI 2078
                |.......|.|:.......||||                     |..|             
  Rat  1226 ----HGITCRPQETCKVEGGEGVCVPN---------------------YHAT------------- 1252

  Fly  2079 PKIENPAHSLPDSIFNASSQLAPEHGPKMARLTKEQPRGSWSPSINDQMQYL-------ELNFAK 2136
                  .....|..:|:..                    .||........||       .:|...
  Rat  1253 ------CWLWGDPHYNSFD--------------------GWSYDFQGTCNYLLAGTICPGINAEG 1291

  Fly  2137 PEPFYGVVM---AGSPEFDNYVTLFKILHSHDGIAYHYLVDETEKPQMFNGPL------------ 2186
            ..||.....   .|:|.. :||.|..:...:..|:.|  .:|..|.:: ||.|            
  Rat  1292 LTPFTVTTKNENRGNPAV-SYVRLVTVTTLNTNISIH--KNEIGKVRV-NGALVTLPVYLAGGRI 1352

  Fly  2187 -----DSRAPVQTLFKIPIEASSLRIYPLKWHGSIAMRVELL-----------ICGDKEEPKPVP 2235
                 .|:|.::|.|.:.:      .|...|      |||:.           :||:.:: ||  
  Rat  1353 SVINGGSKAVLETDFGLQV------TYDWNW------RVEVTLPSSYHSAVCGLCGNMDK-KP-- 1402

  Fly  2236 TVSTILPITERPARLVDLECIDLMGVDEGKMYQDQVQSSSL------WQQPNLGKKLQLLELLKL 2294
                                      :..|::.:...:.|:      ||.|..            
  Rat  1403 --------------------------ENDKVFPNGTVAPSIPAWGGSWQVPGW------------ 1429

  Fly  2295 STPLAWRPLANSQNEFIEFDFLEPRNISGFVTKGGPDGWVTGYKVMFSKKKPTWNTVLSTDGQAR 2359
             .||.|.....|.....| |.:|.....||.   ||....||                       
  Rat  1430 -DPLCWNECQGSCPTCPE-DRVEEYEGPGFC---GPLAPGTG----------------------- 1466

  Fly  2360 IFEANHDAETERRHHFKNPILTQYIKIVPAYWEKNINMRIEPLGCFLPYPEIQRQVPVEESKPTK 2424
                             .|..:.:..:.|..:.|         ||.|                  
  Rat  1467 -----------------GPFASCHSHVPPESFFK---------GCVL------------------ 1487

  Fly  2425 CNICDGVSTSSSTTGCQCQDQLFWDGNTCVQHNLCPCIENYVS--YPIGSKFEN----SACEDCV 2483
             ::|.|                  .||..:   ||..:..|.:  ...|.|.|:    :.|| ..
  Rat  1488 -DVCLG------------------GGNKDI---LCQALAAYAAACQAAGIKIEDWRTQAGCE-IP 1529

  Fly  2484 CVLGGH-KNCKPK---KCP-------------PCLGGKLRPVITSDCFCKCEPCPKHQRLCPSSG 2531
            |....| :.|.|:   .||             ||:.|           |:|:     |....|:.
  Rat  1530 CPDNSHYELCGPRCPASCPPPAQHTPPTACDGPCVEG-----------CQCD-----QGFVLSAD 1578

  Fly  2532 DCIPEI----LWCNGVQDCADDE---DASCSDSFTVEPDVSREKNETEVITCPVPVCPPQMKIRI 2589
            .|:|..    .|.||....|..|   |.:||                                  
  Rat  1579 QCVPLDGGCGCWVNGTYHEAGTEFWTDTTCS---------------------------------- 1609

  Fly  2590 TEKKSRKMSKMFTFSKQVSIVDDGTTITKTKFISSKEQILAMPNRELDFQLEEQCDEFTCVPIPS 2654
                                                                ::|.   |.|   
  Rat  1610 ----------------------------------------------------KRCH---CGP--- 1616

  Fly  2655 KQVDKNETVTCTEPKCPEKYDVELDMSASKVGDCLRYSCVLRPNKDDVCEISG-KSFTTFDGTVF 2718
                ..:::.|....|....:..| :.:.::|      |  :|.....||..| ..:||.||..|
  Rat  1617 ----GGDSLICKSASCGLGEECAL-LPSGEIG------C--QPTSIAECEAWGDPHYTTLDGHRF 1668

  Fly  2719 KY-GPCSHILARDIHS-----SSWSISV---HQ--QCSDETRKVCHKVITIQDT---------EA 2763
            .: |.|.::|:...|:     ..::::|   |:  |....||.|...:..:..|         :.
  Rat  1669 DFQGTCEYLLSAPCHAPPPGIEYFNVTVANEHRGSQAVSYTRSVTLHIYGLSLTLSAQWPRQLQV 1733

  Fly  2764 GNELILLP-HLKLKFNGYEFTVQQLINSPICKASFVVSQPGKTLLAVSTKYGFWVQLDDIGIVKV 2827
            ..|.:.|| ||..|.:.|           |..|..|          |:|..|..:..|....|::
  Rat  1734 NGEFVALPFHLDQKLSVY-----------ISGADVV----------VNTASGLSLAFDGNSFVRL 1777

  Fly  2828 GISSKFIRTVDGLCGYYNGNQKDDKRSPDGQIIPNTEKFGDSWYDKRIPK-DQCGDLKCPR---- 2887
            .:.:.:..::.||||.||.|..||..:.||:  |...|.|.:      |. |||....||:    
  Rat  1778 RVPAAYAGSLCGLCGNYNKNPNDDLTAVDGK--PEGWKVGGA------PGCDQCQPEPCPQPCTP 1834

  Fly  2888 EMQA--KALQLCNIIHHP--TFARCHKAVNYKQFLNNYCLEAACNCMMANNGDPAACKCNILESF 2948
            |.|.  :....|.||..|  ..|.||..|...::. ..||..||..    .|.|... |..:.::
  Rat  1835 EQQEPFRGPDACGIITAPEGPLAPCHSLVPPTKYF-EACLLDACQV----QGHPGGL-CPAIATY 1893

  Fly  2949 VKKCLSVNPLVQLTTWRAVAQCEINCPSPLVHTDCYKRRCEPSCDNVHGDDCPV------LPD-- 3005
            |..|.:..  .||..||....|.:.||:...:..|             ||.|||      .|:  
  Rat  1894 VAACQAAG--AQLGEWRKPDFCPLQCPANSHYQLC-------------GDSCPVSCPSLSAPEGC 1943

  Fly  3006 --ACFPGCYCPEGTVRKGPNCVPISEC-------------------------------------- 3030
              .|..||.|..|.|..|..|||:.:|                                      
  Rat  1944 ETTCREGCVCDSGFVLSGDTCVPVGQCGCLYNGRYYVLGATFYPGPECERLCECGPGGQVTCQEG 2008

  Fly  3031 KDCV---------------------CNSLGASKYMTYDRKSFSFNGNCTYLLS---RDVVLPGVH 3071
            .||.                     |.:.|...|:|.|.:.:..:|:|:|:|:   |.  .||..
  Rat  2009 ADCEPYEECRVENGVQACHPTGCGHCLANGGVHYVTLDGRVYDLHGSCSYVLAGVCRP--KPGEE 2071

  Fly  3072 TFQVYVSMDDCKKLGQPTPVEGGSCAKSLHILNGDHVIHVQRVPQKPKSLQVLVDGFEVKKIPYK 3136
            .|.:.:..|..   |:|..|.         :...|.|:.:.|.|      ||.||| |...:|..
  Rat  2072 EFSIVLEKDSA---GEPQRVV---------VTVADQVVVLARGP------QVTVDG-EAVALPVA 2117

  Fly  3137 DSWISLRQVVGKELVLSLPESHVELTASFE-DLIFSLGVPSIKYGSKMEGLCGDCNGNAGND--- 3197
            .:.:|: ...|:.:||   :::..:...|: |....:.:|| .:..::.||||:.|||..:|   
  Rat  2118 TAHVSV-TAEGRNVVL---QTNKGMKVLFDGDAHILMSIPS-SFRGRICGLCGNFNGNWSDDFVL 2177

  Fly  3198 ----LQPNPAKKKAGVDVI-QSWQADEPKLGLVEECLSEDVP------------KEHCIPLPPEK 3245
                :.||       ||.. .:|:|....||..|.|..:..|            .:.|..:...|
  Rat  2178 PGGAVAPN-------VDAFGAAWRAPSSSLGCSEGCGPQGCPVCLAEETEAYEKNDACGKIRDPK 2235

  Fly  3246 DPCLQFYNAELFGKCPLAVDPIAYVSACQQDICKPGNTQQGVCVALAAYAKECNQHGICTN-WRR 3309
            .|         |..|...:.|:.|...|..|:|.....:..:|.:||||...|...|.... ||.
  Rat  2236 GP---------FATCHKVLSPLEYFRQCVYDMCAHKGDKAYLCRSLAAYTAACQASGAAVKPWRT 2291

  Fly  3310 PQLCPYECPSDMVYEPC--GCAKNCDTIKALSEFDAVSLKNEAVVHTVKTDEMCLSSERFEGCFC 3372
            ...||.:||:...|..|  .|..:|..:..|:.                    | ::..||||.|
  Rat  2292 DSFCPLQCPAHSHYSVCTRSCQGSCAALSGLTG--------------------C-TTRCFEGCEC 2335

  Fly  3373 PPGKVMDGGQCVPEIACTKCDDGLHLP-DEKWKKDKCTE-CQCDSKGKTTCVE------------ 3423
            ....::..|.|:|...|....:|.::| :.......|:| |.|......||..            
  Rat  2336 DDHFLLSQGVCIPAQDCGCVHNGQYVPVNSSLMSSDCSELCYCSETTGLTCRAAGCPSGQVCEIQ 2400

  Fly  3424 ---KKCQVEENICA 3434
               ::|:....:|:
  Rat  2401 AGVRQCRAAHGLCS 2414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 37/166 (22%)
C8 680..754 CDD:285899 15/74 (20%)
TIL 758..811 CDD:280072 18/54 (33%)
VWD 840..1015 CDD:214566 54/177 (31%)
C8 1054..1121 CDD:214843 24/70 (34%)
TIL 1131..1185 CDD:280072 24/54 (44%)
TIL 1245..1298 CDD:280072 4/52 (8%)
VWD 1327..1498 CDD:214566 52/180 (29%)
C8 1535..1609 CDD:214843 22/76 (29%)
Mucin2_WxxW 1751..1837 CDD:290069 9/85 (11%)
TIL 1938..2005 CDD:280072 9/66 (14%)
FA58C 2089..2223 CDD:238014 30/160 (19%)
FA58C 2104..2225 CDD:214572 28/158 (18%)
FA58C <2299..2404 CDD:214572 14/104 (13%)
FA58C <2299..2403 CDD:238014 14/103 (14%)
VWD 2703..2858 CDD:295339 44/176 (25%)
C8 2893..2970 CDD:285899 21/78 (27%)
TIL 2974..3030 CDD:280072 19/65 (29%)
VWD 3035..3198 CDD:295339 44/173 (25%)
C8 3257..3313 CDD:285899 16/56 (29%)
VWC 3397..3451 CDD:302663 9/55 (16%)
GHB_like <3755..3813 CDD:304424
FcgbpNP_001158129.3 VWD 56..210 CDD:395046 37/164 (23%)
C8 251..326 CDD:214843 16/78 (21%)
TIL 329..383 CDD:396409 18/54 (33%)
VWD 448..603 CDD:395046 51/166 (31%)
C8 642..717 CDD:214843 28/77 (36%)
TIL 720..773 CDD:396409 24/54 (44%)
VWC 775..829 CDD:327433 19/142 (13%)
VWD 836..991 CDD:395046 50/171 (29%)
C8 1034..1109 CDD:214843 22/76 (29%)
TIL 1112..1165 CDD:396409 20/73 (27%)
VWC 1167..1219 CDD:327433 22/316 (7%)
VWD 1253..1412 CDD:395046 35/223 (16%)
C8 1451..1526 CDD:214843 22/166 (13%)
TIL 1530..1584 CDD:410995 15/69 (22%)
VWD 1652..1808 CDD:395046 44/176 (25%)
C8 1840..1914 CDD:214843 21/81 (26%)
TIL 1917..1970 CDD:396409 19/65 (29%)
VWD 2024..2180 CDD:214566 44/181 (24%)
C8 2222..2296 CDD:214843 19/82 (23%)
TIL 2299..2352 CDD:396409 16/73 (22%)
VWC 2357..2407 CDD:327433 8/49 (16%)
VWD 2406..2560 CDD:413350 2/9 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11339
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

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