DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hml and LOC100149773

DIOPT Version :9

Sequence 1:	NP_524060.2	Gene:	Hml / 39529	FlyBaseID:	FBgn0029167	Length:	3843	Species:	Drosophila melanogaster
Sequence 2:	XP_021326452.1	Gene:	LOC100149773 / 100149773	-ID:	-	Length:	639	Species:	Danio rerio

Alignment Length:	843	Identity:	191/843 - (22%)
Similarity:	293/843 - (34%)	Gaps:	276/843 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  3035 CNSLGASKYMTYDRKSFSFNGNCTYLLSRDVVLPGVHTFQVYVSMDDCKKLGQPTPVEGGSCAKS 3099
            |...|.|.|:|:|...:::.|||||:|.:::  .......:|:....|      .|.|..||.:|
Zfish     8 CQGWGDSHYITFDGLYYNYQGNCTYILMKEI--SPQFNLAIYIENVYC------DPAENVSCPRS 64

  Fly  3100 L-------------HILNGDHVIHVQ----RVPQKPKSLQVLVDGFEVKKIPYKDSWISLRQVVG 3147
            |             |.|.|...:.|:    |..|:..|   .::|..:..:||.::.:   :|:.
Zfish    65 LIVSYNKQNITLRSHRLMGGANLEVRLLYSRTEQRFCS---ALEGNIMLALPYDNNGL---RVIS 123

  Fly  3148 KELVLSLPESHVELTASFEDLIFSLGVPSIKYGSKMEGLCGDCNGNAGNDLQPNPAKKKAGVDVI 3212
            .:|.|.|....:.....|....||:.:|...:|...||.||.||.|
Zfish   124 SDLNLLLEIPKLNAYVLFGVSGFSINLPFQYFGKNTEGQCGTCNNN------------------- 169

  Fly  3213 QSWQADEPKLGLVEEC--LSEDVPKEHC---IPLP----PEKDPCLQFYNAELFGKCPLAVDPIA 3268
               |.|:....|..:|  ::|:.....|   .|||    |...|.....|. .|..|...|.|..
Zfish   170 ---QNDDCPGSLANDCKIMAENWNTTVCTPPAPLPTPNSPHVHPDCYLLNT-TFEACHSHVPPEN 230

  Fly  3269 YVSACQQDICKPGNTQQGVCVALAAYAKECNQHGICTNWRR-PQLCPYECPSDMVYEPCGCAKNC 3332
            :.||||.|   ..|....||.:|.:||..|...|:|..||. ...|...|..|.|:.|||
Zfish   231 FFSACQYD---SSNNPAEVCASLQSYASVCAMFGVCIYWRNYTSQCNIGCSEDKVFLPCG----- 287

  Fly  3333 DTIKALSEFDAVSLKNEAVVH--TVKTDEMCLSSERFEGCFCPPGKVM---DGGQCVPEIACTKC 3392
                   .|:..:.::..:..  ||.|          |||||.....:   |.|.|||:
Zfish   288 -------SFEPPTCRDRQMESNITVST----------EGCFCSQNTTLFTKDSGVCVPQ------ 329

  Fly  3393 DDGLHLPDEKWKKDKCTECQC-DSKGKTTCVEKKCQVEENICAEGYRPETIVSVDECCPRYRCVP 3456
                             .|.| ||.||                    |..::..     |.:...
Zfish   330 -----------------PCGCLDSSGK--------------------PRRVLYT-----RIKTFN 352

  Fly  3457 ETKDPSKLCLAPLVPICGPGQFKKEKKDVNGCSQYICECIPKDQCEIIELRELLPGEIIVNVEEG 3521
            |                         ...:.|...:|:   |.:..:|
Zfish   353 E-------------------------NFTHNCEDCVCD---KARMSVI----------------- 372

  Fly  3522 CCPTQKIECKPETCPKA-PVNCQERFYEVKTIKEPGMCCSKHSCVPPKDLCIVQYELDEATKFTK 3585
                    |:|:.||.. ||||.|.|..|........|||:..
Zfish   373 --------CEPKKCPDVPPVNCTEPFMVVNVTDPSEPCCSRQD---------------------- 407

  Fly  3586 TVGDKWTHAKEVCKQETCSYGPDGNAQVVSTLEQCL----TDCAPGFSYQNLDKTKCCGKCVQTS 3646
              |.::   |..|:..||::..|.....::.:| |:    .|||.||.|...| .:|||.|||.:
Zfish   408 --GQEF---KYKCETVTCNHINDSFEMNITNME-CIQLSSEDCASGFQYMKKD-GECCGSCVQVA 465

  Fly  3647 CIFEQKLYEVNALWKSAD---NCTTYSCLKKDGQFLVTTSREVCPDVG--SCL--SHLLYQDGCC 3704
            ||::......:.|.:...   :|...:|||::..|.:....:.||...  .|:  :....:||||
Zfish   466 CIYDAPDKTTHVLQEGLSYNISCMNVTCLKRNDVFTIKEEMKKCPSFNQDDCVEGTKQFDEDGCC 530

  Fly  3705 KRCKSEPLVEDKSSCLPVSLAESRTKEILKFPVQGHGTCVNADPIQGFTDCEGACSSGSKYNTLT 3769
            ..|::.       :|.||       |.:.:..|   ..|.:.:.:: .|.|.|.|.|.|   ||
Zfish   531 PNCETR-------NCAPV-------KNVTRLKV---NNCTSTEDVE-ITSCAGHCDSKS---TL- 573

  Fly  3770 DMH---EKFCTCCSIKSYHPISVKMICDDG--------HTFTQKHEVPSNCGCSP--CSEFSD 3819
            |:|   ...|:||..:......|.::|:|.        |.:|    ....|.|:|  |.::::
Zfish   574 DLHGYMMNSCSCCQAERSSIREVTLMCEDDWQKWLNIRHNYT----YIETCTCTPVMCEDYNN 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hml	NP_524060.2	VWD	485..636	CDD:295339
		C8	680..754	CDD:285899
		TIL	758..811	CDD:280072
		VWD	840..1015	CDD:214566
		C8	1054..1121	CDD:214843
		TIL	1131..1185	CDD:280072
		TIL	1245..1298	CDD:280072
		VWD	1327..1498	CDD:214566
		C8	1535..1609	CDD:214843
		Mucin2_WxxW	1751..1837	CDD:290069
		TIL	1938..2005	CDD:280072
		FA58C	2089..2223	CDD:238014
		FA58C	2104..2225	CDD:214572
		FA58C	<2299..2404	CDD:214572
		FA58C	<2299..2403	CDD:238014
		VWD	2703..2858	CDD:295339
		C8	2893..2970	CDD:285899
		TIL	2974..3030	CDD:280072
		VWD	3035..3198	CDD:295339	46/179 (26%)
		C8	3257..3313	CDD:285899	20/56 (36%)
		VWC	3397..3451	CDD:302663	7/54 (13%)
		GHB_like	<3755..3813	CDD:304424	19/68 (28%)
LOC100149773	XP_021326452.1	VWD	8..174	CDD:306577	48/201 (24%)
		C8	212..270	CDD:312319	21/61 (34%)
		CT	545..624	CDD:214482	22/90 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12226at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010