DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hml and muc5.1

DIOPT Version :9

Sequence 1:NP_524060.2 Gene:Hml / 39529 FlyBaseID:FBgn0029167 Length:3843 Species:Drosophila melanogaster
Sequence 2:XP_021326297.1 Gene:muc5.1 / 100148804 ZFINID:ZDB-GENE-120822-1 Length:5282 Species:Danio rerio


Alignment Length:1909 Identity:490/1909 - (25%)
Similarity:756/1909 - (39%) Gaps:412/1909 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   439 LAKYRDLER-RSEWWSSEETVVTMSSYSLYQSNNLDIVIDKTP--RPALCTTWGGINMKTFDGLV 500
            :..|||:|. .:..|.: ...::|:|..:       |.::..|  |..:|:|||..:.|||||..
Zfish    34 MGDYRDMENPMTPMWPT-TPAISMTSVPV-------ITVEPNPDHRSTICSTWGNFHFKTFDGHF 90

  Fly   501 FKAPLSCSHTL--ITDKVSGTFDIILKACPYGSGYGCAHTLKILWQSVLYTFENLNGTMQLTTPI 563
            |:.|.:|::.|  :.|..|..|:|.::.                        |.:||::..:|.:
Zfish    91 FQLPDTCNYVLAVMCDAASSDFNIQMQR------------------------ETVNGSISFSTVL 131

  Fly   564 KKLPMPV-------QVMGMKVMPVAQH---VQIDLESVGLKLD--------WDHRQYVSVQAGPQ 610
            .||...|       ..||.:.:.|..:   ::|:......|:.        |:....:|::...:
Zfish   132 IKLDGTVIKVTDSDITMGEETVTVPTYKNGIKIEGSPTSFKISNKHGVTVFWEEDNSLSIELPEK 196

  Fly   611 MWGKVGGLCGTLDGDPNTDLTSRTGKKLATVKAFADAWRVEDRSELCQVENSAEMEFGMDS---C 672
            ..|:..||||..:|:...|:|....   ||       |:|...:|:|:       |..:.|   |
Zfish   197 YQGQTCGLCGDFNGNLADDITDNGP---AT-------WKVSISTEICE-------EVTLPSTGPC 244

  Fly   673 EQSKLQKAVSVCERLLANEKLGDCIKPFNYDALIRTCMADYCNCANREHPESCNCDAIAMLAKEC 737
            ::  |.:..|.||..|.:.....|....:.....:.|::|.|.|...   ..|.|:.:..::::|
Zfish   245 DE--LSEQASFCEEYLISPGFSGCYDVMDMRIFQKACVSDLCQCYGN---HDCLCNTLTEISRQC 304

  Fly   738 AFKGIKLEHG----WRNLEICPISCGFGRVYQACGPNVEPTCDSDLALPASKGACNEGCFCPEGT 798
            ...|     |    ||..::||.:|.....|..||.....||.:..|.......|.:||||||||
Zfish   305 THAG-----GQPGTWRTEQLCPKTCPLNLQYLECGGPCRNTCSAPTANLMCTDHCVDGCFCPEGT 364

  Fly   799 VQ---YKEACITRELCPCSLRGKEFKPESTVKKNCNTCTCKNGQWRCTEDKCGARCGAVGDPHYQ 860
            |:   .:..|:....|||...|..:|...:.::.|.:|||..|.|.||...|...|..||..|..
Zfish   365 VEDDIGQSGCVPVNECPCVHDGTVYKSGESYQQACKSCTCDAGHWTCTYLDCPGTCSVVGGSHVT 429

  Fly   861 TFDGKRYDFMGKCSYHLLKTQNTSVEAENVACSGAVSESMNFAAPDDPSCTKAVTIRFILRDGTP 925
            |||||.:.|.|.|.|.|.|....|    :.|..|.:::.   .|....:|..:||   ::..|| 
Zfish   430 TFDGKSFTFSGNCDYILTKHSADS----DFAVVGNLAKC---EASRTDTCLHSVT---LVISGT- 483

  Fly   926 SVIKLDQGLTTI--VNDKPIAKLPKMLGLGEVLIRRASSTFLTVEFAD-GIRVWWDGVSRVYIDA 987
            ::.....|..|:  :|.|   :||  ..:|.|.|.:.||:|:.|:... .:.:....|.::||.|
Zfish   484 TISFSSSGDVTLNNINSK---ELP--FSIGPVSIFQPSSSFIIVDLTSVRLEIQLAPVMQLYIVA 543

  Fly   988 PPSLRGQTQGLCGTFNSNTQDDFLTPEGDVETAVEPFADKWRTKDTCQFKAETHQGPHPCTLNPE 1052
            ....:|:..||||.:|....|||.|..|.:|.....|.:.|  |..|.....|..  :||:||.:
Zfish   544 STEEKGKMTGLCGNYNDVQTDDFKTESGIIEGTPTSFVNFW--KQNCPDLEITFD--NPCSLNMD 604

  Fly  1053 KKAQAEKFCDWIL--QDIFQDCHFLVEPEQFYEDCLYDTCACKDEMSKCFCPILSAYGTECMRQG 1115
            .:..|:.:|..:.  ...|.:||..:.||.:|:.|:||||.|.| :.||.|..:|.|...|..:|
Zfish   605 TEKLAKDWCSRLTNPNGTFSECHSEICPEMYYQRCVYDTCKCSD-IRKCICAAVSTYAHACAARG 668

  Fly  1116 VKTGWRMSVKECAVKCPLGQVFD----ECGDGC-ALSCDDLPSKGSCKRECVEGCRCPHGEYVNE 1175
            :.....|..:.|..:||......    .||..| :||..:...:||...  |.||.|..|.|:||
Zfish   669 IILHDWMDTEPCESECPENMKHSYEVTSCGSTCRSLSGQENTCQGSFTP--VHGCVCSEGTYLNE 731

  Fly  1176 DGECVPKKMCHCNFDGMSFRPGYKEVRPGEKFLDLCTCTDGVWDCQDAEPGDKDKYPPSSELRSK 1240
            :|:||...||.|.:.....:|..:..:.|.|    |||.:|..||...|    |...|.:..  |
Zfish   732 EGKCVHAGMCPCYYGNQVIQPSAEFNKEGAK----CTCNNGKLDCSSHE----DCVAPMTFF--K 786

  Fly  1241 CAKQPYAEFTKCAPKEPKTCKNMDKYVADSSDCLPGCVCMEGYVYDTSRLACVLPANCSCHHAGK 1305
            |: .|..:.|:|    .:||...|.....|:.|:.||:|.||.:.| .:..||:..||.|.|.|.
Zfish   787 CS-HPGEKGTEC----QRTCDKQDPNNCVSTGCVSGCMCPEGLLAD-GKGGCVMRENCPCTHNGV 845

  Fly  1306 SYDDGEKIKEDCNLCECRAGNWKCSKNGCESTCSVWGDSHFTTFDGHDFDFQGACDYVLAKGVFD 1370
            :...|:::::|||.|.|..|.|.|::..|..||:::|:.||.||||:.:.|.|.|::.||....|
Zfish   846 TSSPGDQVQQDCNTCTCTNGMWICTQKACYGTCTIYGEGHFRTFDGNRYSFHGDCEHTLAHDYCD 910

  Fly  1371 N--GDGFSITIQNVLCGTMGVTCSKSLEIALTGHAEESLLLSADSAYSTDPNKTPIKKLRDSVNS 1433
            .  ...|.:..:|:.|.|....||||:.:....:  |.:|...|.....:.|.|..|        
Zfish   911 GNPSPSFRLVTENIPCATANSICSKSINLFFGRY--EMILSEDDGVKVVEGNGTEYK-------- 965

  Fly  1434 KGHNAFHIYKAGVFVVVEVIPLKLQVKWDEGTRVYVKLGNEWRQKVSGLCGNYNGNSLDDMQTPS 1498
                 :.|...|::||:|:..| |.:.|||.|.|.::|..:.:..|.|||||::||:.:|....:
Zfish   966 -----YQINYGGIYVVIEIEGL-LNLIWDEKTSVMIQLHPKLKGNVCGLCGNFDGNANNDFMKHN 1024

  Fly  1499 MGLETSPMLFGHAWKLQPHCSAPVAPIDACKKHPERETWAQLKCGALKSDLFKECHAEVPLERFW 1563
            ..:.|.|..||::||:..:|......:..|:.||.|.:||..:|..:.|.:|.:||:.|....::
Zfish  1025 GEVVTDPEEFGNSWKVDSNCPDVTNVMHPCEAHPHRNSWAIKQCRIITSPVFTDCHSLVDSGPYY 1089

  Fly  1564 KRCIFDTCACDQGGDCECLCTAVAAYADACAQKGINIRWRSQHFCPMQCDPH-----CS-DYKAC 1622
            ..|:.||||||.||||:||||||.|||..|.::|..:.||:.||||:.||.:     |. .||.|
Zfish  1090 DACVRDTCACDSGGDCDCLCTAVGAYAAECRKRGACVAWRTPHFCPLFCDYYNAPGECQWHYKTC 1154

  Fly  1623 TPACAVETCDNFLDQGIAERMCNRE-NCLEGCHIKPCEDGFIYLNDTYRDCVPKAECKPVCMVRD 1686
            ...| ::||.|.|.      .|:.: ..||||.:: |.....||.:....||.:..||. |.. |
Zfish  1155 GSTC-MKTCRNPLG------TCSDQIPPLEGCFLQ-CPSERPYLREETMKCVTEEGCKD-CFY-D 1209

  Fly  1687 GKTFYEGDITF--TD---SCATCRCSKRKEICSGVKCD------------------------VPA 1722
            ||.:..|.:.:  ||   :|.:.:|....||...:|.|                        .|:
Zfish  1210 GKVYPRGSVIYNTTDGSGACFSAKCDYNGEIIREIKTDCIITTTPFTFSTPPSTTVTITSTETPS 1274

  Fly  1723 -----------------------TTGLPAPLVEGTTL------PTPLATQNQTK----------- 1747
                                   ||.:.:|..|.:|.      |||.:|.:.|.           
Zfish  1275 TITSTITPTTGTSTPTSTETPITTTSITSPTTETSTSTSTETPPTPASTTSPTTETSTSTSTETP 1339

  Fly  1748 -----------------------------------------CVK--GWTRWCDKDRDTSDKSVRL 1769
                                                     ||.  .|:.|.|.::..::...  
Zfish  1340 STITSTVTPTTETSTPTSTETVPTPSTTTATTTPTSTTTPICVPRCEWSDWIDSNKPNTEPEG-- 1402

  Fly  1770 NDEEKVPRYDRMENVYGTCLKQYMTKVECR-VKDTHEAPEQMDENVVCSLEEGLRCIGK------ 1827
            .:.|.:|.......:  ||  |...:|||| |....:..|.:.:.|.|:...||.|..:      
Zfish  1403 FETESIPLLWNSRRI--TC--QSPEEVECRAVNYPQKTLEDLGQTVYCNTSFGLSCSNEDNAEGL 1463

  Fly  1828 ---CHDYELRAFC---QCDEELEPELPK-PTEKPQLGLACDAAVVEYK-----EFPGDCHKFLHC 1880
               |::||:|.:|   .|..:.....|. .||.|....:..:...|..     |.|..       
Zfish  1464 PPICYNYEIRVYCCKENCPSDTTTSTPSTSTETPSTTTSTTSPTTETSTPTSTETPST------- 1521

  Fly  1881 QPKGVEGGWIYVEKTCGEYMMFNPTMLICDHIATVTEIKPNCGLKPEPEPEFEPIKQCP------ 1939
                       :..|      ..||.......:|.|...|.....|..|.......:.|      
Zfish  1522 -----------ITST------VTPTTGTSTPTSTETPPTPASTTSPTTETSTPTSTETPSTTAST 1569

  Fly  1940 ---------------PGKIKSECANQCE-------NTCHYYGSILKKRGLCQVGEHCKPGC---- 1978
                           |..|.|......|       .|.....:.............|.|.|    
Zfish  1570 TSPTTETSTPTSTETPSTITSTVTPTTETSTPTSTETVPTPSTTTATTPTSTTTPICVPRCEWSD 1634

  Fly  1979 -VDELRPDCPKLG-------KFWRDED-TCVHADECPCMDKAEHYVQPHKPVLGEFEVC------ 2028
             :|..:|:....|       ..|..:. ||...:|..|  :|.:|.|.....||:...|      
Zfish  1635 WIDSNKPNTEPEGFETESIPLLWNSKRITCQSPEEVEC--RAVNYPQKTLEDLGQTVYCNTSFGL 1697

  Fly  2029 QCI--DNA--------------FTCVPNKPEPVPKDEDDDLDLVSVVPIYPVTLTPPLQCSPERL 2077
            .|.  |||              :.|..|.|      .|......|.....|.|.:|    :.|.|
Zfish  1698 SCSNEDNAEGLPPICYNYEIRVYCCKENCP------SDTTTSTPSTSTETPSTTSP----TTETL 1752

  Fly  2078 IPKIENPAHSLPDSIFNASSQLAP 2101
            .|.......::..::...:..|.|
Zfish  1753 TPTSTETPSTITSTVTPTTGTLTP 1776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HmlNP_524060.2 VWD 485..636 CDD:295339 39/170 (23%)
C8 680..754 CDD:285899 16/77 (21%)
TIL 758..811 CDD:280072 18/55 (33%)
VWD 840..1015 CDD:214566 55/177 (31%)
C8 1054..1121 CDD:214843 22/68 (32%)
TIL 1131..1185 CDD:280072 20/58 (34%)
TIL 1245..1298 CDD:280072 16/52 (31%)
VWD 1327..1498 CDD:214566 54/172 (31%)
C8 1535..1609 CDD:214843 34/73 (47%)
Mucin2_WxxW 1751..1837 CDD:290069 23/95 (24%)
TIL 1938..2005 CDD:280072 15/107 (14%)
FA58C 2089..2223 CDD:238014 2/13 (15%)
FA58C 2104..2225 CDD:214572
FA58C <2299..2404 CDD:214572
FA58C <2299..2403 CDD:238014
VWD 2703..2858 CDD:295339
C8 2893..2970 CDD:285899
TIL 2974..3030 CDD:280072
VWD 3035..3198 CDD:295339
C8 3257..3313 CDD:285899
VWC 3397..3451 CDD:302663
GHB_like <3755..3813 CDD:304424
muc5.1XP_021326297.1 VWD 72..217 CDD:214566 38/168 (23%)
C8 263..320 CDD:312319 12/64 (19%)
TIL 324..380 CDD:307783 18/55 (33%)
VWD 420..571 CDD:306577 51/166 (31%)
C8 606..680 CDD:214843 23/74 (31%)
Pacifastin_I 848..>874 CDD:253170 9/25 (36%)
VWD 867..1025 CDD:214566 54/173 (31%)
C8 1063..1135 CDD:214843 34/71 (48%)
Mucin2_WxxW 1386..1476 CDD:315900 23/95 (24%)
Mucin2_WxxW 1631..1721 CDD:315900 18/91 (20%)
Mucin2_WxxW 1895..1985 CDD:315900
Mucin2_WxxW 2141..2231 CDD:315900
Mucin2_WxxW 2366..2456 CDD:315900
Mucin2_WxxW 2612..2702 CDD:315900
Mucin2_WxxW 2814..2904 CDD:315900
Mucin2_WxxW 3060..3150 CDD:315900
Mucin2_WxxW 3306..3396 CDD:315900
Mucin2_WxxW 3552..3642 CDD:315900
Mucin2_WxxW 3798..3888 CDD:315900
VWD 4616..4779 CDD:214566
C8 4818..4880 CDD:312319
CT 5198..5274 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 92 1.000 Domainoid score I7571
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12226at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100854
Panther 1 1.100 - - O PTHR11339
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2291
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.820

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