DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8757 and dhrs11a

DIOPT Version :9

Sequence 1:	NP_648664.2	Gene:	CG8757 / 39528	FlyBaseID:	FBgn0036380	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_001093518.1	Gene:	dhrs11a / 791578	ZFINID:	ZDB-GENE-060929-324	Length:	258	Species:	Danio rerio

Alignment Length:	261	Identity:	96/261 - (36%)
Similarity:	152/261 - (58%)	Gaps:	25/261 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERWCNKVAVVSGASAGIGAACTRALIGAGMIVVGLARRHERVEKLRSGLSLEQQSR-----LHA 60
            ||||..:||:|:|||.|||||..|||:..||.|||.||..:::||    |:.|.||.     |..
Zfish     4 MERWKGRVALVTGASVGIGAAVARALVQHGMKVVGCARNVDKIEK----LAAECQSAGYSGILIP 64

  Fly    61 IKCDITQEDQVLKAFDWTCRQLGGVDVLVSNAGIIGTGE-LSERDDGPAMRSTIETNIMGTVYCV 124
            .|||:..|:::|..|........||||.::|||:..... ||.|.||  .|:.|:.||:....|.
Zfish    65 YKCDLCNEEEILSMFSAIKTLHQGVDVCINNAGLAHNEPLLSGRTDG--WRNMIDVNILALAICT 127

  Fly   125 RESFRSMKRRGT-EGHVVIVNSVAGYQVPNLGPQLPSLNIYPATKFALRAMNEIYRQEFQRHKTA 188
            ||:::||:.|.. :||::.:||:.|:::.:...:    :.|.|||:|:.||.|..|||.:..||.
Zfish   128 REAYQSMRERHVDDGHIININSMGGHRMVSSADE----HFYCATKYAVTAMTEGLRQELREAKTH 188

  Fly   189 VRVSTVSPGIVDTVIL-------PEQIQGIIKQHMPMLRSDDVADAVLWAIGTPPNVQVHNITIK 246
            :|.:.:|||||:|...       ||:...:. :.:..|:::|:|.||.:.:..|.:||:.::.::
Zfish   189 IRATCISPGIVETEFAFRHHNSDPERAAAVY-ESIKCLKAEDIASAVTYVLSAPAHVQIGDVQMR 252

  Fly   247 P 247
            |
Zfish   253 P 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8757	NP_648664.2	YdfG	1..252	CDD:226674	96/261 (37%)
CG8757	NP_648664.2	NADB_Rossmann	1..247	CDD:304358	95/259 (37%)
dhrs11a	NP_001093518.1	YdfG	4..258	CDD:226674	96/261 (37%)
dhrs11a	NP_001093518.1	Mgc4172-like_SDR_c	4..253	CDD:187601	95/259 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576259
Domainoid	1	1.000	169	1.000	Domainoid score	I3763
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3745
OMA	1	1.010	-	-		QHG45743
OrthoDB	1	1.010	-	-		D1190834at2759
OrthoFinder	1	1.000	-	-		FOG0000588
OrthoInspector	1	1.000	-	-		mtm6354
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X367
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870