DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8757 and HSD11B1L

DIOPT Version :9

Sequence 1:	NP_648664.2	Gene:	CG8757 / 39528	FlyBaseID:	FBgn0036380	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_001254797.1	Gene:	HSD11B1L / 374875	HGNCID:	30419	Length:	333	Species:	Homo sapiens

Alignment Length:	208	Identity:	49/208 - (23%)
Similarity:	90/208 - (43%)	Gaps:	17/208 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VVSGASAGIG--AACTRALIGAGMIVVGLARRHERVEKLRSGLSLEQQSRLHAIKCDITQEDQVL 72
            :::||:||:|  .|...|.:|:.:::.  |.....::|:..........::..|..|:...:...
Human    80 LLTGANAGVGEELAYHYARLGSHLVLT--AHTEALLQKVVGNCRKLGAPKVFYIAADMASPEAPE 142

  Fly    73 KAFDWTCRQLGGVDVLVSNAGIIGTGELSERDDGP-AMRSTIETNIMGTVYCVRESFRSMKRRGT 136
            ....:...:|||:|.||.|.  ||......|...| |.|..::.|.:..|.....:..|:  ..:
Human   143 SVVQFALDKLGGLDYLVLNH--IGGAPAGTRARSPQATRWLMQVNFVSYVQLTSRALPSL--TDS 203

  Fly   137 EGHVVIVNSVAGYQVPNLGPQLPSLNI-YPATKFALRAMNEIYRQEFQRHKTAVRVSTVSPGIVD 200
            :|.:|:|:|:.| :||.      |.:. |.|.||||.......|:|.......|.::....|:.|
Human   204 KGSLVVVSSLLG-RVPT------SFSTPYSAAKFALDGFFGSLRRELDVQDVNVAITMCVLGLRD 261

  Fly   201 TVILPEQIQGIIK 213
            .....|.::|:.:
Human   262 RASAAEAVRGVTR 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8757	NP_648664.2	YdfG	1..252	CDD:226674	49/208 (24%)
CG8757	NP_648664.2	NADB_Rossmann	1..247	CDD:304358	49/208 (24%)
HSD11B1L	NP_001254797.1	GVQW	3..>26	CDD:290611
		NADB_Rossmann	74..302	CDD:304358	49/208 (24%)
		PRK08251	78..302	CDD:181324	49/208 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900