Protein Alignment CG8757 and DHRS7B

DIOPT Version :10

• Sequence 1: NP_648664.2
• Gene: CG8757 / 39528
• FlyBaseID: FBgn0036380
• Length: 252
• Species: Drosophila melanogaster
• Sequence 2: XP_047291678.1
• Gene: DHRS7B / 25979
• HGNCID: 24547
• Length: 372
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 71/265 - (26%)
• Similarity: 123/265 - (46%)
• Gaps: 34/265 - (12%)

  Fly     6 NKVAVVSGASAGIGAACTRALIGAGMIVVGLARRHERVEKLRSGLSLEQQSRL-----HAIKCDI 65
            |.|.|::||::|:|..|.:....||..:|...|....:|:|...|:....:::     :.:..|:
Human    99 NAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDL 163

  Fly    66 TQEDQVLKAFDWTCRQLGGVDVLVSNAGIIGTGELSERDDGPAMRSTIETNIMGTVYCVRESFRS 130
            |....::.|.....:..|.||:||:||||...|.:.:.......| .:|||..|.|...:....|
Human   164 TDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKR-VMETNYFGPVALTKALLPS 227

  Fly   131 M-KRRGTEGHVVIVNSVAGYQVPNLGPQLPSLNIYPATKFALRAMNEIYRQEFQRHKTAVRVSTV 194
            | |||  :||:|.::|:.|..      .:|..:.|.|:|.|.:|..:..|.|.::::  :.|:.:
Human   228 MIKRR--QGHIVAISSIQGKM------SIPFRSAYAASKHATQAFFDCLRAEMEQYE--IEVTVI 282

  Fly   195 SPGIVDTVILPEQI------QGIIKQHMPMLRSD-DVADAVLWAIGTP----------PNVQVHN 242
            |||.:.|.:....|      .|::.......||. :||..||.|:|..          |::.|:.
Human   283 SPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYL 347

  Fly   243 ITIKP 247
            .|:.|
Human   348 RTLAP 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8757	NP_648664.2	Rossmann-fold NAD(P)(+)-binding proteins	1..247	CDD:473865	70/263 (27%)
DHRS7B	XP_047291678.1	11beta-HSD1_like_SDR_c	97..358	CDD:187593	71/265 (27%)