DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru3 and Celf3

DIOPT Version :9

Sequence 1:	NP_001369050.1	Gene:	bru3 / 39527	FlyBaseID:	FBgn0264001	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001276542.1	Gene:	Celf3 / 78784	MGIID:	1926034	Length:	494	Species:	Mus musculus

Alignment Length:	456	Identity:	228/456 - (50%)
Similarity:	278/456 - (60%)	Gaps:	106/456 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MNRALQLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAF 85
            |||.:|:|||::|||.|  |||||||||.||||::|||::|.|||||:|||:||||||.||||||
Mouse    77 MNRPIQVKPADSESRGE--DRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAF 139

  Fly    86 VKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNPFVFNQFSP 150
            |||.:..|||:||..||.|:|:||||||||||:|||||||.:|||||:|..:.:.:|... ||..
Mouse   140 VKFQTHAEAQAAINTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVATQLGMFSPIAL-QFGA 203

  Fly   151 YGAYAQ--QQQQAALMAAAATAPGSAAAYMNPMAAL-ATQIPH-------GL--------NGTGQ 197
            |.||.|  .||||||:||       .:||::|||.: |.|:.|       ||        :||..
Mouse   204 YSAYTQALMQQQAALVAA-------HSAYLSPMATMAAVQMQHMAAISANGLIATPITPSSGTST 261

  Fly   198 PPSL---PSPTMPNFNMGAN-------TPNGQPGGAAAAAAAAAAADGVFTNGIPQTAFPGHPLH 252
            ||::   |...:| ..:|.|       .|.|||           |.|.::.||:  ..:|...|.
Mouse   262 PPAIAATPVSAIP-AALGVNGYSPVPTQPTGQP-----------APDALYPNGV--HPYPDEALS 312

  Fly   253 LTIPPQGLP---------------NGDAA---TLQHAFPGLPPFPGVAFPAVYG----QFPQALP 295
            ......|:|               ...||   .||.|:.|:..:. .|:||.|.    .|||  |
Mouse   313 AERSAGGVPIMSQAHSWLVMLSAAQSPAAPVDPLQQAYAGMQHYT-AAYPAAYSLVAPAFPQ--P 374

  Fly   296 PPLAAVAP------------------TQREDFLMFPGCSISGPEGCNLFIYHLPQEFGDAELMQM 342
            |.|.|..|                  .|||           ||:|||:|||||||||.|:|::||
Mouse   375 PALVAQQPPPPPQQQQQQQQQQQQQQQQRE-----------GPDGCNIFIYHLPQEFTDSEILQM 428

  Fly   343 FLPFGNVISSKVFIDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRP 407
            |:|||:|||:|||:||||||||||||||||||||||||||||||||||||||||||||||||:||
Mouse   429 FVPFGHVISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRP 493

  Fly   408 Y 408
            |
Mouse   494 Y 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru3	NP_001369050.1	RRM2_CELF3_4_5_6	40..120	CDD:410043	59/79 (75%)
		ELAV_HUD_SF	43..404	CDD:273741	209/428 (49%)
		RRM3_CELF3_4_5_6	319..397	CDD:241083	67/77 (87%)
Celf3	NP_001276542.1	RRM1_CELF3_4_5_6	2..88	CDD:410041	7/10 (70%)
		RRM2_CELF3_4_5_6	94..174	CDD:410043	59/79 (75%)
		PRK12323	<214..379	CDD:237057	53/188 (28%)
		RRM3_CELF3_4_5_6	405..483	CDD:241083	67/77 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5028
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2056
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		otm42784
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840