DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru3 and CELF5

DIOPT Version :9

Sequence 1:	NP_001369050.1	Gene:	bru3 / 39527	FlyBaseID:	FBgn0264001	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_068757.2	Gene:	CELF5 / 60680	HGNCID:	14058	Length:	485	Species:	Homo sapiens

Alignment Length:	407	Identity:	225/407 - (55%)
Similarity:	262/407 - (64%)	Gaps:	55/407 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MNRALQLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAF 85
            |.|.:|:|||::|||... |||||||||:|||:|:||.::|.|||.|:|||:||||||:||||||
Human   115 MARPIQVKPADSESRGGR-DRKLFVGMLNKQQSEEDVLRLFQPFGVIDECTVLRGPDGSSKGCAF 178

  Fly    86 VKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNPFVFNQFSP 150
            |||.|..|||:||..|||||||||||||||||:|||:|||.:||||||.|.:.:|.|.:...|||
Human   179 VKFSSHTEAQAAIHALHGSQTMPGASSSLVVKFADTDKERTLRRMQQMVGQLGILTPSLTLPFSP 243

  Fly   151 YGAYAQQQQQAALMAAAATAPGSAAAYMNPMAALA----TQI-PHGLNGTGQPPSLPSPTMPNFN 210
            |.||||     |||....|...::.:|::|..|.:    .|| ...|||....|..|:
Human   244 YSAYAQ-----ALMQQQTTVLSTSGSYLSPGVAFSPCHIQQIGAVSLNGLPATPIAPA------- 296

  Fly   211 MGANTPNGQP--GGAAAAAAAAAAADGVFTNGIPQTAFP-GHPLHLTIPPQGL-------PNGDA 265
            .|.::|   |  |..|.....|...:| |...:|   || |||...|:...||       |. .|
Human   297 SGLHSP---PLLGTTAVPGLVAPITNG-FAGVVP---FPGGHPALETVYANGLVPYPAQSPT-VA 353

  Fly   266 ATLQHAFPGLPP----FPGVAFPAVYGQFPQALPPPLAAVAPTQREDFLMFPGCSISGPEGCNLF 326
            .||..||.|:..    :|..|...:....||  ||||  :...|||           ||||||||
Human   354 ETLHPAFSGVQQYTAMYPTAAITPIAHSVPQ--PPPL--LQQQQRE-----------GPEGCNLF 403

  Fly   327 IYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGM 391
            ||||||||||.||.||||||||:||||||:|||||||||||||||||||||||||||||||||||
Human   404 IYHLPQEFGDTELTQMFLPFGNIISSKVFMDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGM 468

  Fly   392 KRLKVQLKRPKDASRPY 408
            ||||||||||||...||
Human   469 KRLKVQLKRPKDPGHPY 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru3	NP_001369050.1	RRM2_CELF3_4_5_6	40..120	CDD:410043	61/79 (77%)
		ELAV_HUD_SF	43..404	CDD:273741	210/379 (55%)
		RRM3_CELF3_4_5_6	319..397	CDD:241083	73/77 (95%)
CELF5	NP_068757.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		RRM1_CELF3_4_5_6	40..126	CDD:410041	6/10 (60%)
		half-pint	46..>372	CDD:130706	131/277 (47%)
		RRM2_CELF3_4_5_6	133..213	CDD:410043	61/79 (77%)
		RRM3_CELF3_4_5_6	396..474	CDD:241083	73/77 (95%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159203
Domainoid	1	1.000	140	1.000	Domainoid score	I4775
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75172
Inparanoid	1	1.050	380	1.000	Inparanoid score	I2069
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770