DRSC/TRiP Functional Genomics Resources

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Protein Alignment bru3 and CELF4

DIOPT Version :10

Sequence 1:NP_001369050.1 Gene:bru3 / 39527 FlyBaseID:FBgn0264001 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_001340669.1 Gene:CELF4 / 56853 HGNCID:14015 Length:545 Species:Homo sapiens


Alignment Length:463 Identity:201/463 - (43%)
Similarity:242/463 - (52%) Gaps:116/463 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 MNRALQLKPAENESRS--------EHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPD 77
            |||.:|:|||::|||.        ...|||||||||:|||:|||||::|..||.|||||||||||
Human   124 MNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEECTILRGPD 188

  Fly    78 GASKGCAFVKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNP 142
            |.||||||||:.|..|||:||..|||||||||||||||||:|||:|||.:||||||||.|.:.||
Human   189 GNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNP 253

  Fly   143 FVFNQFSPYGAYAQ--QQQQAALMAAAATAPGSAAAYMNPMAALAT---QIPHGLN--------- 193
            ... .|..||||||  .||||||||:.|     ...|:|||||.|.   |....||         
Human   254 MAI-PFGAYGAYAQALMQQQAALMASVA-----QGGYLNPMAAFAAAQMQQMAALNMNGLAAAPM 312

  Fly   194 ----GTGQPPSLPSPTMPNF--NMGAN-------TPNGQPGGAAAAAAAAAAADGVFTNGIPQTA 245
                |...||.:.:|.:|:.  .:|.|       ..||||           ||:.||.|||    
Human   313 TPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQP-----------AAEAVFANGI---- 362

  Fly   246 FPGHPLHLTIPPQGLPNGDAATLQHAFPGLPPFPG-VAFPAVYGQFPQALPPPLAAVAPTQREDF 309
               ||.....|....|      ||.|:.|:..:.| .|:||.|||..||.|.|...:...|||  
Human   363 ---HPYPAQSPTAADP------LQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPPMIPQQQRE-- 416

  Fly   310 LMFPGCSISGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATNQSKCFGFVSFDNP 374
                     |||||||||||||||||||||||||||||.                        :|
Human   417 ---------GPEGCNLFIYHLPQEFGDAELMQMFLPFGR------------------------HP 448

  Fly   375 ASAQAAIQAMNGFQI----GMKRLKVQLKRPKDASRPYXQSEFLKRNSQQPTGA----------T 425
            ..|:....:..|.|.    ..:||: :|::|...:..: ..|.|....::..||          .
Human   449 VPARCQAPSCQGGQCPINSSTRRLR-ELRQPGQRADRHPGHERLPDRHEEAQGAAEAAQRRQSPV 512

  Fly   426 TSATGALP 433
            .||.|::|
Human   513 LSAGGSVP 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bru3NP_001369050.1 RRM2_CELF3_4_5_6 40..120 CDD:410043 63/79 (80%)
ELAV_HUD_SF 43..404 CDD:273741 180/392 (46%)
RRM3_CELF3_4_5_6 319..397 CDD:241083 35/81 (43%)
CELF4NP_001340669.1 Sufficient for RNA-binding and MSE-dependent splicing activity 1..298 113/179 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..39
RRM1_CELF3_4_5_6 49..135 CDD:410041 7/10 (70%)
PABP-1234 <56..378 CDD:130689 139/283 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..149 10/24 (42%)
RRM2_CELF3_4_5_6 151..231 CDD:410043 63/79 (80%)
Necessary for TNNT2 exon 5 inclusion 239..258 11/19 (58%)
RRM_SF 417..>445 CDD:473069 27/27 (100%)
Blue background indicates that the domain is not in the aligned region.

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