DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru3 and celf1

DIOPT Version :9

Sequence 1:	NP_001369050.1	Gene:	bru3 / 39527	FlyBaseID:	FBgn0264001	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_012816629.1	Gene:	celf1 / 549906	XenbaseID:	XB-GENE-854036	Length:	534	Species:	Xenopus tropicalis

Alignment Length:	456	Identity:	185/456 - (40%)
Similarity:	240/456 - (52%)	Gaps:	104/456 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MNRALQLKPAENESRS---------EH----LDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTI 72
            |:..:|:|||::|..:         ||    .||||||||:||:..|:|:|.:|..||.|||..|
Frog   115 MHHPIQMKPADSEKNNGGLNTVLYPEHPASVEDRKLFVGMVSKKCNENDIRAMFSQFGQIEESRI 179

  Fly    73 LRGPDGASKGCAFVKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRM-QQMAGH 136
            ||||||.|:|||||.|.::..||.||..:|.:|||.|.||.:|||:|||:|:::.:|| ||:...
Frog   180 LRGPDGMSRGCAFVTFTTRSMAQMAIKAMHQAQTMEGCSSPIVVKFADTQKDKEQKRMTQQLQQQ 244

  Fly   137 MNLLNPFV-------FNQFSPY----------------------------GAYA----------Q 156
            |..||...       .:..:|.                            |.||          |
Frog   245 MQQLNAASMWGNLAGLSSLAPQYLALYLQLLQQTASSGNLNSLSGLHPMGGEYATGMTSGLNAMQ 309

  Fly   157 QQQQAALMAAAATA---PGSAAAYMNPMAALATQIPHGLNGTGQPPSL--PSPTMPNFNMGA-NT 215
            .|..|||.|||:.|   |.:.:|.....:.|:.     |..:|..||.  .|...|..::|| .|
Frog   310 LQNLAALAAAASAAQNTPSAGSALTTSSSPLSI-----LTSSGSSPSSNNNSAVNPMASLGALQT 369

  Fly   216 PNGQPGGAAAAAAAAAAADGVFTNGIPQTAFPGHPLHLTIPPQGLPNGDAAT---LQHAFPGLPP 277
            ..|...|....:.|..||   ...|:..:               |.||..:|   |..|:.|:..
Frog   370 LAGATAGLNVGSLAGMAA---LNGGLGSS---------------LSNGTGSTMEALSQAYSGIQQ 416

  Fly   278 FPGVAFPAVYGQFPQALPPPLAAVAPTQREDFLMFPGCSISGPEGCNLFIYHLPQEFGDAELMQM 342
            :...|.|::|.|  ..|.......|.:|:|           ||||.|||||||||||||.:|:||
Frog   417 YAAAALPSLYNQ--SLLSQQGLGAAGSQKE-----------GPEGANLFIYHLPQEFGDQDLLQM 468

  Fly   343 FLPFGNVISSKVFIDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRP 407
            |:|||||:|:|||||:.||.||||||||:|||.|||||||:|||||||||||||||||.|:.|:|
Frog   469 FMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKP 533

  Fly   408 Y 408
            |
Frog   534 Y 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru3	NP_001369050.1	RRM2_CELF3_4_5_6	40..120	CDD:410043	47/79 (59%)
		ELAV_HUD_SF	43..404	CDD:273741	171/415 (41%)
		RRM3_CELF3_4_5_6	319..397	CDD:241083	64/77 (83%)
celf1	XP_012816629.1	RRM1_CELF1_2_Bruno	42..125	CDD:241075	4/9 (44%)
		ELAV_HUD_SF	45..529	CDD:273741	181/449 (40%)
		RRM2_CELF1_2	147..227	CDD:241078	47/79 (59%)
		RRM3_CELF1_2	442..533	CDD:241082	73/101 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930