DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru3 and Celf3

DIOPT Version :9

Sequence 1:	NP_001369050.1	Gene:	bru3 / 39527	FlyBaseID:	FBgn0264001	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_038958836.1	Gene:	Celf3 / 499669	RGDID:	1563168	Length:	526	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	227/490 - (46%)
Similarity:	277/490 - (56%)	Gaps:	142/490 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MNRALQLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAF 85
            |||.:|:|||::|||.|  |||||||||.||||::|||::|.|||||:|||:||||||.||||||
  Rat    77 MNRPIQVKPADSESRGE--DRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAF 139

  Fly    86 VKFGSQQEAQSAITNLHGSQTMP-------------------------GASSSLVVKYADTEKER 125
            |||.:..|||:||..||.|:|:|                         |||||||||:|||||||
  Rat   140 VKFQTHAEAQAAINTLHSSRTLPEARGKTRPPREQTLTLPVTCGAHAQGASSSLVVKFADTEKER 204

  Fly   126 QIRRMQQMAGHMNLLNPFVFNQFSPYGAYAQ--QQQQAALMAAAATAPGSAAAYMNPMAAL-ATQ 187
            .:|||||:|..:.:.:|... ||..|.||.|  .||||||:||       .:||::|||.: |.|
  Rat   205 GLRRMQQVATQLGMFSPIAL-QFGAYSAYTQALMQQQAALVAA-------HSAYLSPMATMAAVQ 261

  Fly   188 IPH-------GL--------NGTGQPPSL---PSPTMPNFNMGAN-------TPNGQPGGAAAAA 227
            :.|       ||        :||..||::   |...:| ..:|.|       .|.|||
  Rat   262 MQHMAAINANGLIATPITPSSGTSTPPAIAATPVSAIP-AALGVNGYSPVPTQPTGQP------- 318

  Fly   228 AAAAAADGVFTNGI--------------------PQTAFPGHPLHLTIPPQGLPNGDAATLQHAF 272
                |.|.::.||:                    |||    |...:.:.....|......||.|:
  Rat   319 ----APDALYPNGVHPYPDEALSAERSAGEAPIMPQT----HSWLVMLSAAQSPAAPVDPLQQAY 375

  Fly   273 PGLPPFPGVAFPAVYG----QFPQALPPPLAAVAP-------------------------TQRED 308
            .|:..:. .|:||.|.    .|||  ||.|.|..|                         .|||
  Rat   376 AGMQHYT-AAYPAAYSLVAPAFPQ--PPALVAQQPPPPPQQQQQQQQQQQQQQQQQQQQQQQRE- 436

  Fly   309 FLMFPGCSISGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATNQSKCFGFVSFDN 373
                      ||:|||:|||||||||.|:|::|||:|||:|||:|||:|||||||||||||||||
  Rat   437 ----------GPDGCNIFIYHLPQEFTDSEILQMFVPFGHVISAKVFVDRATNQSKCFGFVSFDN 491

  Fly   374 PASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRPY 408
            |||||||||||||||||||||||||||||||:|||
  Rat   492 PASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru3	NP_001369050.1	RRM2_CELF3_4_5_6	40..120	CDD:410043	59/104 (57%)
		ELAV_HUD_SF	43..404	CDD:273741	208/462 (45%)
		RRM3_CELF3_4_5_6	319..397	CDD:241083	67/77 (87%)
Celf3	XP_038958836.1	RRM1_CELF3_4_5_6	2..88	CDD:410041	7/10 (70%)
		RRM2_CELF3_4_5_6	94..199	CDD:410043	59/104 (57%)
		minC	<242..>376	CDD:178806	38/156 (24%)
		RRM3_CELF3_4_5_6	437..515	CDD:241083	67/77 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4875
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2015
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		otm44845
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840