DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru3 and celf4

DIOPT Version :9

Sequence 1:	NP_001369050.1	Gene:	bru3 / 39527	FlyBaseID:	FBgn0264001	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_009293466.1	Gene:	celf4 / 436835	ZFINID:	ZDB-GENE-040718-300	Length:	541	Species:	Danio rerio

Alignment Length:	453	Identity:	242/453 - (53%)
Similarity:	279/453 - (61%)	Gaps:	93/453 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MNRALQLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAF 85
            |||.:|:|||::|||.|  |||||||||:|||.|||||::|..||:||||||||||||.||||||
Zfish   117 MNRPIQVKPADSESRGE--DRKLFVGMLNKQQCEDDVRRLFESFGSIEECTILRGPDGNSKGCAF 179

  Fly    86 VKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNPFVFNQFSP 150
            ||:.:..|||:||:.|||||||||||||||||:|||:|||.|||||||||.|.:.||... ||..
Zfish   180 VKYSTHAEAQAAISALHGSQTMPGASSSLVVKFADTDKERTIRRMQQMAGQMGIFNPMAL-QFGA 243

  Fly   151 YGAYAQQQQQAALMAAAATAPGSAAAYMNPMAAL-ATQIPH-----GL--------NGTGQPPSL 201
            ||||||.||||||||:.     ....|::||||. |.|:.|     ||        :|...||.:
Zfish   244 YGAYAQVQQQAALMASV-----GQGGYLSPMAAFAAAQMQHMATINGLPGAPMTPTSGGSTPPGI 303

  Fly   202 PSPTMPNFNMGANTPNGQPGGAAAAAAAAAAADGVFTNGIPQTAFPGHPLHLT-----------I 255
            .:||:.:.....:. ||..|.....|...|.|:.:|||||       ||..:.           :
Zfish   304 TAPTVTSIPSPISV-NGFTGLPPPQANGQAPAEAMFTNGI-------HPYPVVFMSSATEESKRL 360

  Fly   256 PPQGLP--------------------------NGD--------------AATLQHAFPGLPPFPG 280
            .|..:|                          .|.              |..||.|:.|:..: .
Zfish   361 SPGCIPVLQEVVFREDSEKGGLGVAQRSCFGVQGSCFLSSLSEAQSPTAADPLQQAYAGVQQY-A 424

  Fly   281 VAFPAVYGQFPQALPPPLAAVAPTQREDFLMFPGCSISGPEGCNLFIYHLPQEFGDAELMQMFLP 345
            .||||.|||..||.|.|...:...|||           ||||||||||||||||||.||||||||
Zfish   425 AAFPAAYGQISQAFPQPPPIIPQQQRE-----------GPEGCNLFIYHLPQEFGDGELMQMFLP 478

  Fly   346 FGNVISSKVFIDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRPY 408
            ||||||||||:||||||||||||||||||.|||||||:|||||||||||||||||||||:|||
Zfish   479 FGNVISSKVFVDRATNQSKCFGFVSFDNPGSAQAAIQSMNGFQIGMKRLKVQLKRPKDANRPY 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru3	NP_001369050.1	RRM2_CELF3_4_5_6	40..120	CDD:410043	62/79 (78%)
		ELAV_HUD_SF	43..404	CDD:273741	223/425 (52%)
		RRM3_CELF3_4_5_6	319..397	CDD:241083	73/77 (95%)
celf4	XP_009293466.1	RRM1_CELF3_4_5_6	42..128	CDD:241076	7/10 (70%)
		ELAV_HUD_SF	49..537	CDD:273741	237/447 (53%)
		RRM2_CELF3_4_5_6	134..214	CDD:241079	62/79 (78%)
		RRM3_CELF3_4_5_6	452..530	CDD:241083	73/77 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4686
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1843
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		otm25077
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980