DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru3 and Celf5

DIOPT Version :9

Sequence 1:	NP_001369050.1	Gene:	bru3 / 39527	FlyBaseID:	FBgn0264001	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001361632.1	Gene:	Celf5 / 319586	MGIID:	2442333	Length:	446	Species:	Mus musculus

Alignment Length:	427	Identity:	222/427 - (51%)
Similarity:	259/427 - (60%)	Gaps:	96/427 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MNRALQLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAF 85
            |.|.:|:|||::|||... |||||||||:|||:|:||.::|.|||.|:|||:||||||:||||||
Mouse    77 MARPIQVKPADSESRGGR-DRKLFVGMLNKQQSEEDVLRLFQPFGVIDECTVLRGPDGSSKGCAF 140

  Fly    86 VKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNPFVFNQFSP 150
            |||.|..|||:||..|||||||||||||||||:|||:|||.:||||||.|.:.:|.|.:...|||
Mouse   141 VKFSSHTEAQAAIHALHGSQTMPGASSSLVVKFADTDKERTLRRMQQMVGQLGILTPSLTLPFSP 205

  Fly   151 YGAYAQQQQQAALMAAAATAPGSAAAYMNPMAALATQIPHGLNGTGQPPSLPSPTMPNFNMGANT 215
            |.||||     |||....|...::.:|::|             |...||....      .:||.:
Mouse   206 YSAYAQ-----ALMQQQTTVLSTSGSYLSP-------------GVAFPPCHIQ------QIGAVS 246

  Fly   216 PNGQPGGAAAAAAAAAAADGVFTNGIPQT-AFPGHPLHLTIPPQGLPNGDAATLQHAFPGLPPFP 279
            .||.|      |...|.|.|:.:..:..| |.||    |..|   :|||        |||:.|||
Mouse   247 LNGLP------ATPIAPASGLHSPPLLGTAAVPG----LMAP---IPNG--------FPGVLPFP 290

  Fly   280 G-------------VAFPAVYGQFPQALPP------------PLAAVAPT-------------QR 306
            |             |.:||......:.|.|            |.||:||.             ||
Mouse   291 GSHPALETVYANGLVPYPAQSPTVAETLHPAFSGVQQYTAMYPTAAIAPVAHSVPQPPHLLQQQR 355

  Fly   307 EDFLMFPGCSISGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATNQSKCFGFVSF 371
            |           ||||||||||||||||||.||.||||||||:||||||:|||||||||||||||
Mouse   356 E-----------GPEGCNLFIYHLPQEFGDTELTQMFLPFGNIISSKVFMDRATNQSKCFGFVSF 409

  Fly   372 DNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRPY 408
            |:||||||||||||||||||||||||||||||...||
Mouse   410 DHPASAQAAIQAMNGFQIGMKRLKVQLKRPKDPGHPY 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru3	NP_001369050.1	RRM2_CELF3_4_5_6	40..120	CDD:410043	61/79 (77%)
		ELAV_HUD_SF	43..404	CDD:273741	207/399 (52%)
		RRM3_CELF3_4_5_6	319..397	CDD:241083	72/77 (94%)
Celf5	NP_001361632.1	RRM1_CELF3_4_5_6	2..88	CDD:241076	6/10 (60%)
		PABP-1234	<9..358	CDD:130689	140/337 (42%)
		RRM2_CELF3_4_5_6	95..175	CDD:241079	61/79 (77%)
		RRM3_CELF3_4_5_6	357..435	CDD:241083	72/77 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849573
Domainoid	1	1.000	138	1.000	Domainoid score	I4848
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75172
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2056
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		otm42784
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770