DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru3 and Celf5

DIOPT Version :9

Sequence 1:	NP_001369050.1	Gene:	bru3 / 39527	FlyBaseID:	FBgn0264001	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_038934951.1	Gene:	Celf5 / 314647	RGDID:	1565016	Length:	446	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	221/412 - (53%)
Similarity:	257/412 - (62%)	Gaps:	66/412 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MNRALQLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAF 85
            |.|.:|:|||::|:|... |||||||||:|||:|:||.::|.|||.|:|||:||||||:||||||
  Rat    77 MARPIQVKPADSENRGGR-DRKLFVGMLNKQQSEEDVLRLFQPFGVIDECTVLRGPDGSSKGCAF 140

  Fly    86 VKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNPFVFNQFSP 150
            |||.|..|||:||..|||||||||||||||||:|||:|||.:||||||.|.:.:|.|.:...|||
  Rat   141 VKFSSHTEAQAAIHALHGSQTMPGASSSLVVKFADTDKERTLRRMQQMVGQLGILTPSLTLPFSP 205

  Fly   151 YGAYAQQQQQAALMAAAATAPGSAAAYMNPMAALATQIPHGLNGTGQPPSLPSPTMPNFNMGANT 215
            |.||||     |||....|...::.:|::|             |...||....      .:|..:
  Rat   206 YSAYAQ-----ALMQQQTTVLSTSGSYLSP-------------GVAFPPCHIQ------QIGTVS 246

  Fly   216 PNGQPGGAAAAAA--------AAAAADGVFT---NGIPQT-AFPG-HPLHLTIPPQGL------- 260
            .||.|....|.|:        ..||..|:.|   :|.|.. .||| ||...|:...||
  Rat   247 LNGLPATPIAPASGLHSPPLLGTAAVPGLMTSIPSGFPGVLPFPGSHPALETVYANGLVPYPAQS 311

  Fly   261 PNGDAATLQHAFPGLPP----FPGVAFPAVYGQFPQALPPPLAAVAPTQREDFLMFPGCSISGPE 321
            |. .|.||..||.|:..    :|..|...|....||  ||.|   ...|||           |||
  Rat   312 PT-VAETLHPAFSGVQQYTAMYPTAAIAPVAHSVPQ--PPHL---LQQQRE-----------GPE 359

  Fly   322 GCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATNQSKCFGFVSFDNPASAQAAIQAMNG 386
            |||||||||||||||.||.||||||||:||||||:||||||||||||||||:|||||||||||||
  Rat   360 GCNLFIYHLPQEFGDTELTQMFLPFGNIISSKVFMDRATNQSKCFGFVSFDHPASAQAAIQAMNG 424

  Fly   387 FQIGMKRLKVQLKRPKDASRPY 408
            |||||||||||||||||...||
  Rat   425 FQIGMKRLKVQLKRPKDPGHPY 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru3	NP_001369050.1	RRM2_CELF3_4_5_6	40..120	CDD:410043	61/79 (77%)
		ELAV_HUD_SF	43..404	CDD:273741	207/384 (54%)
		RRM3_CELF3_4_5_6	319..397	CDD:241083	72/77 (94%)
Celf5	XP_038934951.1	RRM1_CELF3_4_5_6	2..88	CDD:410041	6/10 (60%)
		PABP-1234	<9..358	CDD:130689	139/322 (43%)
		RRM2_CELF3_4_5_6	95..175	CDD:410043	61/79 (77%)
		RRM3_CELF3_4_5_6	357..435	CDD:241083	72/77 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I4915
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75172
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2015
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		otm44845
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840