DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru3 and Celf6

DIOPT Version :9

Sequence 1:	NP_001369050.1	Gene:	bru3 / 39527	FlyBaseID:	FBgn0264001	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	XP_008764449.1	Gene:	Celf6 / 300758	RGDID:	1310451	Length:	481	Species:	Rattus norvegicus

Alignment Length:	413	Identity:	224/413 - (54%)
Similarity:	262/413 - (63%)	Gaps:	72/413 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MNRALQLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAF 85
            |||.:|:|||.:|.|.|  |||||||||.|||.|:|||::|.|||.|||||:||.|||.||||||
  Rat   116 MNRPIQVKPAASEGRGE--DRKLFVGMLGKQQGEEDVRRLFQPFGHIEECTVLRSPDGTSKGCAF 178

  Fly    86 VKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNPFVFNQFSP 150
            ||||||.|||:||..||||:||.|||||||||.|||::||.:||||||||.:...:|      :|
  Rat   179 VKFGSQGEAQAAIQGLHGSRTMTGASSSLVVKLADTDRERALRRMQQMAGQLGAFHP------AP 237

  Fly   151 Y-----GAY--AQQQQQAALMAAAATAPG-----SAAAYMNPMAAL-----------ATQIPHGL 192
            .     |||  |..|.||||: |||..||     :.||.|..:||.           |...|.|
  Rat   238 LPLGACGAYTTAILQHQAALL-AAAQGPGLGQVAAVAAQMQHVAAFSLVAAPLLPAAANTSPSG- 300

  Fly   193 NGTGQPPSLPSPTMPNFNMGANTP--NGQPGGAAAAAAAAAAADGVFTNGIPQTAFPGHPLHLTI 255
            ||.|..|.||:|...| ..|:..|  |||||           :|.::.||:  :.:|..
  Rat   301 NGPGALPGLPAPMGVN-GFGSLNPQTNGQPG-----------SDSLYNNGL--SPYPAQ------ 345

  Fly   256 PPQGLPNGDAATLQHAFPGLPPFPGVAFPAVYGQFPQALPPPLAAVAPTQREDFLMFPGCSISGP 320
                 ..|.|..||.|:.|:..: ..|:|:.|.....|.|...:|:...|||           ||
  Rat   346 -----SPGVADPLQQAYVGIHHY-AAAYPSAYAPVSTAFPQQPSALPQQQRE-----------GP 393

  Fly   321 EGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATNQSKCFGFVSFDNPASAQAAIQAMN 385
            |||||||||||||||||||:|.|||||.|:|:|||:||||||||||||||||||.|||.||||||
  Rat   394 EGCNLFIYHLPQEFGDAELIQTFLPFGAVVSAKVFVDRATNQSKCFGFVSFDNPTSAQTAIQAMN 458

  Fly   386 GFQIGMKRLKVQLKRPKDASRPY 408
            |||||||||||||||||||:|||
  Rat   459 GFQIGMKRLKVQLKRPKDANRPY 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru3	NP_001369050.1	RRM2_CELF3_4_5_6	40..120	CDD:410043	62/79 (78%)
		ELAV_HUD_SF	43..404	CDD:273741	206/385 (54%)
		RRM3_CELF3_4_5_6	319..397	CDD:241083	69/77 (90%)
Celf6	XP_008764449.1	RRM1_CELF3_4_5_6	41..127	CDD:410041	7/10 (70%)
		PABP-1234	<48..390	CDD:130689	140/309 (45%)
		RRM2_CELF3_4_5_6	133..213	CDD:410043	62/79 (78%)
		RRM3_CELF3_4_5_6	392..470	CDD:241083	69/77 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353218
Domainoid	1	1.000	134	1.000	Domainoid score	I4875
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2015
OMA	1	1.010	-	-		QHG54704
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		otm44845
orthoMCL	1	0.900	-	-		OOG6_100683
Panther	1	1.100	-	-	LDO	PTHR24012
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910