Protein Alignment bru3 and CELF3

DIOPT Version :10

• Sequence 1: NP_001369050.1
• Gene: bru3 / 39527
• FlyBaseID: FBgn0264001
• Length: 552
• Species: Drosophila melanogaster
• Sequence 2: NP_009116.3
• Gene: CELF3 / 11189
• HGNCID: 11967
• Length: 465
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 226/437 - (51%)
• Similarity: 274/437 - (62%)
• Gaps: 97/437 - (22%)

  Fly    21 MNRALQLKPAENESRSEHLDRKLFVGMLSKQQTEDDVRQIFHPFGTIEECTILRGPDGASKGCAF 85
            |||.:|:|||::|||.|  |||||||||.||||::|||::|.|||||:|||:||||||.||||||
Human    77 MNRPIQVKPADSESRGE--DRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAF 139

  Fly    86 VKFGSQQEAQSAITNLHGSQTMPGASSSLVVKYADTEKERQIRRMQQMAGHMNLLNPFVFNQFSP 150
            |||.:..|||:||..||.|:|:||||||||||:|||||||.:|||||:|..:.:.:|... ||..
Human   140 VKFQTHAEAQAAINTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVATQLGMFSPIAL-QFGA 203

  Fly   151 YGAYAQ--QQQQAALMAAAATAPGSAAAYMNPMAAL-ATQIPH-------GL--------NGTGQ 197
            |.||.|  .||||||:||       .:||::|||.: |.|:.|       ||        :||..
Human   204 YSAYTQALMQQQAALVAA-------HSAYLSPMATMAAVQMQHMAAINANGLIATPITPSSGTST 261

  Fly   198 PPSL---PSPTMPNFNMGAN-------TPNGQPGGAAAAAAAAAAADGVFTNGIPQTAFPGHPLH 252
            ||::   |...:| ..:|.|       .|.|||           |.|.::.||:       ||.
Human   262 PPAIAATPVSAIP-AALGVNGYSPVPTQPTGQP-----------APDALYPNGV-------HPY- 306

  Fly   253 LTIPPQGLPNGDAATLQHAFPGLPPFPGVAFPAVYG----QFPQALPPPLAAVAP---------- 303
                |...|......||.|:.|:..:. .|:||.|.    .|||  ||.|.|..|
Human   307 ----PAQSPAAPVDPLQQAYAGMQHYT-AAYPAAYSLVAPAFPQ--PPALVAQQPPPPPQQQQQQ 364

  Fly   304 -------TQREDFLMFPGCSISGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFIDRATN 361
                   .|||           ||:|||:|||||||||.|:|::|||:|||:|||:|||:|||||
Human   365 QQQQQQQQQRE-----------GPDGCNIFIYHLPQEFTDSEILQMFVPFGHVISAKVFVDRATN 418

  Fly   362 QSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRPY 408
            |||||||||||||||||||||||||||||||||||||||||||:|||
Human   419 QSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bru3	NP_001369050.1	RRM2_CELF3_4_5_6	40..120	CDD:410043	59/79 (75%)
		ELAV_HUD_SF	43..404	CDD:273741	207/409 (51%)
		RRM3_CELF3_4_5_6	319..397	CDD:241083	67/77 (87%)
CELF3	NP_009116.3	RRM1_CELF3_4_5_6	2..88	CDD:410041	7/10 (70%)
		RRM2_CELF3_4_5_6	94..174	CDD:410043	59/79 (75%)
		PRK12323	<214..>351	CDD:481241	51/170 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..379		10/43 (23%)
		RRM3_CELF3_4_5_6	376..454	CDD:241083	67/77 (87%)