DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-beta and PPFIBP1

DIOPT Version :9

Sequence 1:	NP_001261806.1	Gene:	Liprin-beta / 39524	FlyBaseID:	FBgn0036376	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_016875545.1	Gene:	PPFIBP1 / 8496	HGNCID:	9249	Length:	1036	Species:	Homo sapiens

Alignment Length:	989	Identity:	262/989 - (26%)
Similarity:	386/989 - (39%)	Gaps:	372/989 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VAEGSKMLEAALQQMDGLISSTAT----------QAGSVSISGAGSSLTLSERNLISATNVLSTA 58
            :::.|.||.|||:||||:|:.:..          |:.:....|:..:|.|.| :|.....::.|.
Human     2 MSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVE-DLRGLLEMMETD 65

  Fly    59 KTLALALQQVGLAAPAPDPVTAAIISDWLET-----HIPRQDS--DERMRRLQRDKEGLALQYQM 116
                   ::.||....||. ||..:.:||::     |:|....  .||:.||:.|||.|.||..:
Human    66 -------EKEGLRCQIPDS-TAETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSV 122

  Fly   117 LAERVSEQADKIIELEGLITEKSQQLCTKEEQLQRQMISSSALETQKLELMSALSELKLHRTALE 181
            |.::|..|.:||.:||..:.|..:::...||.||::::|.::||||||:||:.:|.|||..||:|
Human   123 LTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAEISNLKLKLTAVE 187

  Fly   182 Q---------------------------------------------------------------- 182
            :
Human   188 KDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEK 252

  Fly   183 ----------------------------------------------------------------- 182

Human   253 QRMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDENFKKKLKEKNIEVQ 317

  Fly   183 -----------AN---------------------------------DG-------GSAISANIPY 196
                       ||                                 ||       .|:||:.:..
Human   318 KMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKKGKDGEYEELLNSSSISSLLDA 382

  Fly   197 GSLSNINQK----AFMGSPKTPPSALRHQIKPQFHS-------------------------LPRS 232
            ...|::.:.    ..||||...|  ....:..:||:                         .|:.
Human   383 QGFSDLEKSPSPTPVMGSPSCDP--FNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKP 445

  Fly   233 HGKFVNNNNN------------------------------------------------------- 242
            ...|..|:.|
Human   446 ETSFEENDGNIILGATVDTQLCDKLLTSSLQKSSSLGNLKKETSDGEKETIQKTSEDRAPAESRP 510

  Fly   243 ------------RALDVNANSSGKQRN--------------VAFASN------------------ 263
                        .::|.|...:.|.|:              .|.|.|
Human   511 FGTLPPRPPGQDTSMDDNPFGTRKVRSSFGRGFFKIKSNKRTASAPNLDRKRSASAPTLAETEKE 575

  Fly   264 --EHILIDDNHHQAEDAMTSSFMSQFTPSPKLRERSARGLRNILGKLRRSNSSNCELTALEQAEP 326
              ||:.:.....:.:|:..:|......|||..:::| ||:..:.||||||.|:.  ....:.:||
Human   576 TAEHLDLAGASSRPKDSQRNSPFQIPPPSPDSKKKS-RGIMKLFGKLRRSQSTT--FNPDDMSEP 637

  Fly   327 EFRRGGARATAGGRIEWSAQTPLFGEN----EKHWTTWGAQEVCNWLAYMGLGCYEDNCRKWLNA 387
            ||:|||.|||||.|:.||..   .|::    :..:..|..::|||||...|||.|.::.:.|:.:
Human   638 EFKRGGTRATAGPRLGWSRD---LGQSNSDLDMPFAKWTKEQVCNWLMEQGLGSYLNSGKHWIAS 699

  Fly   388 NPSVSFFTASPVDIERELNLKMPLHRKKILLAIDDLTGKEFDDLTLKASSLDVTWVLRWLDDIGL 452
            ..::  ..||..|:|:||.:|..|||||:.||:..|..:|    ......||..||.||||||||
Human   700 GQTL--LQASQQDLEKELGIKHSLHRKKLQLALQALGSEE----ETNHGKLDFNWVTRWLDDIGL 758

  Fly   453 PQYKDYFMQAKIDGRMLHRLTLEDLSQLHVSSCLHIASLRAGILCMRRLSWNAEGLIRRSIKVVS 517
            ||||..|.:.::||||||.:|::||..|.|.|.||..|::..|..:|..::....|.||     .
Human   759 PQYKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLRINNFEPNCLRRR-----P 818

  Fly   518 EDEAAATPDRDNVELWTAHRIMGWLQTIDLSEYTPNLRGAGVHGALMLYEPRFNADLLADLLSIP 582
            .||....|  ..|:.||.||:|.||:::||:||.|||||:||||.||:.|||||.:.:|.||:||
Human   819 SDENTIAP--SEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIP 881

  Fly   583 PSKSLLRRHLAMHFKELVGRPVILSKRDAESAPGYQPLSITAKLKPVKRTQFS----LKRRKSSK 643
            |:|:|||||||.||..|:|......||||...|.|..|:.|||:|| |:..||    |:::|..
Human   882 PNKTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKVKP-KKLAFSNFGNLRKKKQE- 944

  Fly   644 SQSDVDWTEYVCPM 657
                 |..||||||
Human   945 -----DGEEYVCPM 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-beta	NP_001261806.1	SAM_liprin-beta1,2_repeat1	357..422	CDD:188962	25/64 (39%)
		SAM	359..423	CDD:197735	25/63 (40%)
		SAM_liprin-beta1,2_repeat2	438..499	CDD:188965	33/60 (55%)
		SAM	439..499	CDD:197735	32/59 (54%)
		SAM_liprin-beta1,2_repeat3	529..600	CDD:188968	44/70 (63%)
		SAM	530..599	CDD:197735	44/68 (65%)
PPFIBP1	XP_016875545.1	SMC_N	<47..352	CDD:330553	55/313 (18%)
		SAM_liprin-beta1,2_repeat1	669..732	CDD:188962	25/64 (39%)
		SAM_liprin-beta1,2_repeat2	743..805	CDD:188965	33/61 (54%)
		SAM_liprin-beta1,2_repeat3	828..899	CDD:188968	44/70 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151917
Domainoid	1	1.000	153	1.000	Domainoid score	I4295
eggNOG	1	0.900	-	-		E1_KOG1899
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2685
Inparanoid	1	1.050	390	1.000	Inparanoid score	I2010
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	1	1.000	-	-		FOG0002604
OrthoInspector	1	1.000	-	-		otm41425
orthoMCL	1	0.900	-	-		OOG6_104783
Panther	1	1.100	-	-	LDO	PTHR12587
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2993
SonicParanoid	1	1.000	-	-		X1710
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790