DRSC/TRiP Functional Genomics Resources

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Protein Alignment Liprin-beta and PPFIBP2

DIOPT Version :9

Sequence 1:NP_001261806.1 Gene:Liprin-beta / 39524 FlyBaseID:FBgn0036376 Length:680 Species:Drosophila melanogaster
Sequence 2:NP_001338782.2 Gene:PPFIBP2 / 8495 HGNCID:9250 Length:928 Species:Homo sapiens


Alignment Length:893 Identity:257/893 - (28%)
Similarity:374/893 - (41%) Gaps:279/893 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 AEGSKMLEAALQQMDGLISSTATQAGSVSISGAGSSLTLSERNLISATN------VLSTAKTLAL 63
            ::.|..|||||:||||:|:.|.|        ||..|....|..|.|..:      ||...:.|.|
Human     3 SDASHALEAALEQMDGIIAGTKT--------GADLSDGTCEPGLASPASYMNPFPVLHLIEDLRL 59

  Fly    64 AL-------QQVGLAAPAPDPVTAAIISDWLETHIPR---------QDSDERMRRLQRDKEGLAL 112
            ||       ::..|.:..|.| |||.|.:|.|..:.:         :...||:.||:.|||.|.|
Human    60 ALEMLELPQERAALLSQIPGP-TAAYIKEWFEESLSQVNHHSAASNETYQERLARLEGDKESLIL 123

  Fly   113 QYQMLAERVSEQADKIIELEGLITEKSQQLCTKEEQLQRQMISSSALETQKLELMSALSELKLHR 177
            |..:|.::|..|.:||.:||..:.....:|...||.||::::|.::||||||:||:.:|||||..
Human   124 QVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELLSRTSLETQKLDLMTEVSELKLKL 188

  Fly   178 TALEQ------------------------------------------------------------ 182
            ..:|:                                                            
Human   189 VGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLKATKAEVAQLQEQVALKDAE 253

  Fly   183 --------------------------------------AND------------------------ 185
                                                  ||:                        
Human   254 IERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVM 318

  Fly   186 ---GGS----AISANIPYGSLSNIN------QKAF------------MGSPKTPPSALRHQIKPQ 225
               |.|    :|:...|.|..|..|      ::.|            :|.|..|..:|..:.:.:
Human   319 VTQGPSERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKK 383

  Fly   226 F-----------------------------------HSLPRSHGKFVNNNNNRAL---------- 245
            .                                   |..|...||......|...          
Human   384 LSCSLEDLRSESVDKCMDGNQPFPVLEPKDSPFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQP 448

  Fly   246 DVNANS-----SGKQRNVAFASNEHILIDDNHHQAEDAMTSSF-----MSQFTPSPKLRERSARG 300
            |...:|     .|:..:.....:.....||.....:.:.|||.     .|..||..|   |:.:|
Human   449 DATGSSLLRLNRGRSVSAPVLGDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGK---RNPKG 510

  Fly   301 LRNILGKLRRSNSSNCELTALEQAEPEFRRGGARATAGGRI---------EWSAQTPLFGENEKH 356
            ::...||:||:.|.|.....|..|  ||||||.|||||.|:         :..|..|        
Human   511 IKKFWGKIRRTQSGNFYTDTLGMA--EFRRGGLRATAGPRLSRTRDSKGQKSDANAP-------- 565

  Fly   357 WTTWGAQEVCNWLAYMGLGCYEDNCRKWLNANPSVSFFTASPVDIERELNLKMPLHRKKILLAID 421
            :..|..:.||.||...||..|....|:|:::..::  .||:|.|:|:||.:|.||||||::||:.
Human   566 FAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTL--LTATPQDMEKELGIKHPLHRKKLVLAVK 628

  Fly   422 DLTGKEFDDLTLKASSLDVTWVLRWLDDIGLPQYKDYFMQAKIDGRMLHRLTLEDLSQLHVSSCL 486
            .:..|:.:    |::.||..||.|||||||||||||.|.::::|.|||..||:.||..|.|:|.|
Human   629 AINTKQEE----KSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQL 689

  Fly   487 HIASLRAGILCMRRLSWNAEGLIRRSIKVVSEDEAAATPDRDNVELWTAHRIMGWLQTIDLSEYT 551
            |..|::..|..:....:|...|.||     ..||:..:|  ..|..|:.||:|.||:::||:||.
Human   690 HHLSIKCAIHVLHVNKFNPHCLHRR-----PADESNLSP--SEVVQWSNHRVMEWLRSVDLAEYA 747

  Fly   552 PNLRGAGVHGALMLYEPRFNADLLADLLSIPPSKSLLRRHLAMHFKELVGRPVILSKRDAESAPG 616
            |||||:||||.|::.||||..|.||.||:|||.|:||||||...|..|:|......||:..::|.
Human   748 PNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKREKMASPA 812

  Fly   617 YQPLSITAKLKPVKRTQFS----LKRRKSSKSQSDVDWTEYVCPMNAS 660
            |.||:.|||::| ::..||    ::::|..:|      |:|:|||..|
Human   813 YTPLTTTAKVRP-RKLGFSHFGNIRKKKFDES------TDYICPMEPS 853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Liprin-betaNP_001261806.1 SAM_liprin-beta1,2_repeat1 357..422 CDD:188962 26/64 (41%)
SAM 359..423 CDD:197735 26/63 (41%)
SAM_liprin-beta1,2_repeat2 438..499 CDD:188965 33/60 (55%)
SAM 439..499 CDD:197735 32/59 (54%)
SAM_liprin-beta1,2_repeat3 529..600 CDD:188968 41/70 (59%)
SAM 530..599 CDD:197735 41/68 (60%)
PPFIBP2NP_001338782.2 SMC_prok_B 59..>317 CDD:274008 51/258 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..376 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 425..451 4/25 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..511 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 538..564 10/25 (40%)
SAM_liprin-beta1,2_repeat1 566..629 CDD:188962 26/64 (41%)
SAM_liprin-beta1,2_repeat2 640..702 CDD:188965 33/61 (54%)
SAM_liprin-beta1,2_repeat3 725..796 CDD:188968 41/70 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151918
Domainoid 1 1.000 153 1.000 Domainoid score I4295
eggNOG 1 0.900 - - E1_KOG1899
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 390 1.000 Inparanoid score I2010
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D255905at33208
OrthoFinder 1 1.000 - - FOG0002604
OrthoInspector 1 1.000 - - otm41425
orthoMCL 1 0.900 - - OOG6_104783
Panther 1 1.100 - - O PTHR12587
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2993
SonicParanoid 1 1.000 - - X1710
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.790

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