DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-beta and ppfibp1a

DIOPT Version :9

Sequence 1:	NP_001261806.1	Gene:	Liprin-beta / 39524	FlyBaseID:	FBgn0036376	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_005164718.1	Gene:	ppfibp1a / 565020	ZFINID:	ZDB-GENE-041210-298	Length:	880	Species:	Danio rerio

Alignment Length:	860	Identity:	247/860 - (28%)
Similarity:	379/860 - (44%)	Gaps:	244/860 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VAEGSKMLEAALQQMDGLISSTATQAGSVSISGAGSSLTLSERNLISATN----VLSTAKTLALA 64
            :.:.|:||.|||:||||:|              |||........|....:    .|.:.:.|.|
Zfish     2 MCDASEMLAAALEQMDGII--------------AGSKAMTYTNGLFDCQSPTSPFLGSIRALHL- 51

  Fly    65 LQQVGLAAPAPDP------------VTAAIISDWLETHIPRQDS--------DERMRRLQRDKEG 109
            |:.:..|....||            .||..:.:||:..:.....        .||:.||:.|||.
Zfish    52 LEDLRAALDLMDPEEKENMRSQVSETTAEGLMEWLQGRLTNGHGSAAGDLVHQERLSRLESDKEC 116

  Fly   110 LALQYQMLAERVSEQADKIIELEGLITEKSQQLCTKEEQLQRQMISSSALETQKLELMSALSELK 174
            |.||..:|.::|..|.:||.:|:..:.|...:|...||.||::::|.|.||.:||||::.:|.||
Zfish   117 LVLQVSVLTDQVEVQGEKIRDLDSSLEEHHMKLNATEELLQQELLSRSTLEAEKLELLTEISSLK 181

  Fly   175 LHRTALE---QANDG--GSAISANIPYGSLSNINQ--KAFMGSPKTPPSALRHQIKPQFHSLPRS 232
            |...|.|   :..:|  .......:...|:.|..|  :..:.|.|....:|:.|::.:..:..|.
Zfish   182 LKLAAAEGDCRECEGLFQDVKDLRLKLTSMENERQHYERSLISTKEELISLQKQLEEREQAFKRI 246

  Fly   233 HGKFVNNNNNRALDVNANSSGKQRNVAF-----------ASNE---------------------- 264
            ..:.|....|     ...|..|:|:|..           |:||
Zfish   247 QDRGVPETLN-----TEQSQSKERDVEVQRLRSAMESLKATNEEKDFRIKELQQSLIHYRRVQDI 306

  Fly   265 ----HILID------------DNH--------------------------HQAEDAMTSSFMSQF 287
                |:|.|            |:.                          |...|:::....|:.
Zfish   307 GKTVHVLKDNLSDEDTREGLCDSEMLSTGGTEETDEPQLIPCSELLPEVPHTPTDSVSEVQQSER 371

  Fly   288 TP-------------------------------------------------------SPKLRE-- 295
            :|                                                       :|.|.|
Zfish   372 SPLTSSNEDEASKNRGFPSISPTQPSSGRNESFGSKKTRSSFGRGFFKIRGNKMTGSAPSLAEGE 436

  Fly   296 ----------------------------RSARGLRNILGKLRRSNSSNCELTALEQAEPEFRRGG 332
                                        :.::|:..:.|:::||.|::.:|.  :..:.||:|||
Zfish   437 QKGTEHLDLAGVQTKKQKALDTHSPDGKKKSKGIMKLFGRMKRSQSTSSDLD--DSPDSEFQRGG 499

  Fly   333 ARATAGGRIEWSAQTPLFGENEKH--WTTWGAQEVCNWLAYMGLGCYEDNCRKWLNANPSVSFFT 395
            .|||||.|:.||........||.:  ::.|..::||.||...|||.|.:..::|:.:..::  ..
Zfish   500 VRATAGPRLGWSRDLQRSNNNELNSAFSRWSKEQVCEWLQEQGLGLYMNQAQQWIKSGHTL--LK 562

  Fly   396 ASPVDIERELNLKMPLHRKKILLAIDDLTGKEFDDLTLKASSLDVTWVLRWLDDIGLPQYKDYFM 460
            ||..|.|:||.::.||||||:.||:..|:.::.|.:    ..||..||.:|||||||||||..|.
Zfish   563 ASQHDWEKELGIRHPLHRKKLQLALQSLSSEDGDAM----GKLDYNWVTQWLDDIGLPQYKSQFD 623

  Fly   461 QAKIDGRMLHRLTLEDLSQLHVSSCLHIASLRAGILCMRRLSWNAEGLIRRSIKVVSEDEAAATP 525
            :.::||||||.:|::||..|.|.|.||..|::..|..:|...::...|.||.|      |..|||
Zfish   624 EGRVDGRMLHYMTVDDLLGLKVGSVLHHLSIKRAIQVLRLNGYDPNCLRRRPI------ENNATP 682

  Fly   526 DRDNVEL--WTAHRIMGWLQTIDLSEYTPNLRGAGVHGALMLYEPRFNADLLADLLSIPPSKSLL 588
                .|:  ||.||:|.||:::||:||.|||||:||||.||:.|||||.:.:|.||:|||:|:||
Zfish   683 ----AEICQWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMALLLNIPPNKTLL 743

  Fly   589 RRHLAMHFKELVGRPVILSKRDAESAPGYQPLSITAKLKPVKRTQF----SLKRRKSSKSQSDVD 649
            |||||.||..|:|......|::....|.|..|:.||::|| :|..|    :|:|    |.|.|::
Zfish   744 RRHLATHFHLLIGSEAQKQKQEYLENPDYTVLTATARVKP-RRLSFGSFGTLRR----KRQEDME 803

  Fly   650 WTEYVCPMNASVPET 664
              ||||||:..:|::
Zfish   804 --EYVCPMDVQMPQS 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-beta	NP_001261806.1	SAM_liprin-beta1,2_repeat1	357..422	CDD:188962	24/64 (38%)
		SAM	359..423	CDD:197735	24/63 (38%)
		SAM_liprin-beta1,2_repeat2	438..499	CDD:188965	32/60 (53%)
		SAM	439..499	CDD:197735	31/59 (53%)
		SAM_liprin-beta1,2_repeat3	529..600	CDD:188968	44/72 (61%)
		SAM	530..599	CDD:197735	44/70 (63%)
ppfibp1a	XP_005164718.1	KASH_CCD	107..297	CDD:291334	52/194 (27%)
		SAM	526..590	CDD:197735	24/65 (37%)
		SAM_liprin-beta1,2_repeat1	526..589	CDD:188962	24/64 (38%)
		SAM_liprin-beta1,2_repeat2	600..662	CDD:188965	32/61 (52%)
		SAM	602..662	CDD:197735	31/59 (53%)
		SAM_liprin-beta1,2_repeat3	684..755	CDD:188968	44/70 (63%)
		SAM	687..754	CDD:197735	43/66 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586512
Domainoid	1	1.000	137	1.000	Domainoid score	I4845
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2050
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	1	1.000	-	-		FOG0002604
OrthoInspector	1	1.000	-	-		otm25681
orthoMCL	1	0.900	-	-		OOG6_104783
Panther	1	1.100	-	-	O	PTHR12587
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1710
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900