DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Liprin-beta and ppfibp1b

DIOPT Version :9

Sequence 1:	NP_001261806.1	Gene:	Liprin-beta / 39524	FlyBaseID:	FBgn0036376	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001038435.1	Gene:	ppfibp1b / 561961	ZFINID:	ZDB-GENE-060503-47	Length:	1013	Species:	Danio rerio

Alignment Length:	976	Identity:	269/976 - (27%)
Similarity:	386/976 - (39%)	Gaps:	349/976 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VAEGSKMLEAALQQMDGLISSTAT----------QAGSVSISGAGSSLTLSERNLISATNVLSTA 58
            :::.|.||.|||:||||:|:.:..          |:.:....|:..:|.|.| :|.....::.|.
Zfish     2 MSDASDMLAAALEQMDGIIAGSKALDYSNGIFDCQSPTSPFMGSLRALNLLE-DLRGILELMETE 65

  Fly    59 KTLALALQQVGLAAPAPDPVTAAIISDWLETHIPR----------QDSDERMRRLQRDKEGLALQ 113
            :..:|..|       .||. ||..:.:||..|:..          ||   |:.||:.|||.|.||
Zfish    66 ERESLRCQ-------IPDS-TADSLVEWLHGHLSNGHISISGDVYQD---RLNRLESDKESLVLQ 119

  Fly   114 YQMLAERVSEQADKIIELEGLITEKSQQLCTKEEQLQRQMISSSALETQKLELMSALSELKLHRT 178
            ..:|.::|..|.:||.:|:..:.|..::|...||.||::::..|||||||||||:.:|.|||...
Zfish   120 VSVLTDQVDAQGEKIRDLDLCLDEHREKLNATEEMLQQELLCRSALETQKLELMTEVSNLKLKLA 184

  Fly   179 AL--------EQANDGGSAISAN-------------IPY-----------GSLSNINQKAFM--- 208
            |:        |:..|.|..:..|             :.|           ..||::..|...
Zfish   185 AMDKERLDFDERFGDEGLILEINELRYRISEMENERLQYEKKLKSTKSLMAKLSSLKLKMGQMQY 249

  Fly   209 --------------------------------------GSPKTPPSAL----------------- 218
                                                  ||..:.|:.|
Zfish   250 EKQRKEQKIEALKEELVSLRRQQEGRDGVDLRRLQDESGSRSSTPAGLDGTERVYVMLNVSLRVN 314

  Fly   219 ----------------------------------------RHQIKPQFHSLPR----------SH 233
                                                    ..:|:....||.|          :|
Zfish   315 VLTFSVSEMDFSLLSLCFADMEVQKMKKAMESLMAANEEKDRKIEELRQSLMRYKKVQEMVMSAH 379

  Fly   234 GK--------------------------------------------------FVNNNNNRALDVN 248
            |:                                                  ||:.....:|.|:
Zfish   380 GRKEKVKEGDSDESNSDSSLSMSTALSFSIDTDKSLLAYTEEAARAQNEASTFVSTLQVPSLTVS 444

  Fly   249 A----------------------------------------NSSGKQRNVAFASNEHILIDDNHH 273
            :                                        ..||.|.|:...::|.....|..:
Zfish   445 SPDKADSDSVLEHMQSSDKECEEPDQSQETPLHESPESSEVTKSGSQGNLDGGTSEKSKKFDEFN 509

  Fly   274 Q--------------AED------AMTSSFMSQF---------TPSPKLRE-------------- 295
            :              |||      .|.|||...|         ..:|.|.|
Zfish   510 KITTLPPKSTSSSGTAEDDSFGTRKMRSSFGRGFFKLKGGKRTASAPNLSETERDGTDHLDLAGL 574

  Fly   296 --RSA------------------RGLRNILGKLRRSNSSNCELTALEQAEPEFRRGGARATAGGR 340
              |||                  :|.:.:.|||:||.|:...|.. ..:|.||:|||.|||||.|
Zfish   575 PQRSADSDSTHTLPISPEGKKKSKGFKALFGKLKRSQSTTFNLDD-NLSESEFKRGGVRATAGPR 638

  Fly   341 IEWSAQTPLFGEN---EKHWTTWGAQEVCNWLAYMGLGCYEDNCRKWLNANPSVSFFTASPVDIE 402
            :.||..  |...|   :..:..|..::||:|:...|||.|....|:|:::..::  ..||..|:|
Zfish   639 LGWSRD--LQNTNSDLDAPFARWSREQVCDWMQEQGLGLYVTLARQWVSSGQTL--LQASQHDLE 699

  Fly   403 RELNLKMPLHRKKILLAIDDLTGKEFDDLTLKASSLDVTWVLRWLDDIGLPQYKDYFMQAKIDGR 467
            |||.:|.||||||:.||:..| |.|.||   ....||..||.||||||||||||..|.:.::|||
Zfish   700 RELGIKHPLHRKKLQLALQAL-GSEEDD---NKGKLDYHWVTRWLDDIGLPQYKTQFDEGRVDGR 760

  Fly   468 MLHRLTLEDLSQLHVSSCLHIASLRAGILCMRRLSWNAEGLIRRSIKVVSEDEAAATPDRDNVEL 532
            |||.:|::||..|.|.|.||..|::..|..:|..:::...|.||     ..||...:|  ..:..
Zfish   761 MLHYMTVDDLLSLKVGSVLHHLSIKRAIQVLRLNNYDPNCLRRR-----PSDENNISP--AEISQ 818

  Fly   533 WTAHRIMGWLQTIDLSEYTPNLRGAGVHGALMLYEPRFNADLLADLLSIPPSKSLLRRHLAMHFK 597
            ||.||:|.||:::||:||.|||||:||||.||:.|||||.:.:|.||:|||:|:|||||||.||.
Zfish   819 WTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMALLLNIPPNKTLLRRHLATHFN 883

  Fly   598 ELVGRPVILSKRDAESAPGYQPLSITAKLKPVKRTQFSLKRRKSSKSQSDVDWTEYVCPMNASVP 662
            .|||......|::....|.|..|:.|||:||.|.......|:|..:     |..||||||:..:|
Zfish   884 LLVGSEAQQLKQECLENPDYALLTATAKVKPHKLAFVGFGRKKKQE-----DNEEYVCPMDVEMP 943

  Fly   663 E 663
            :
Zfish   944 K 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-beta	NP_001261806.1	SAM_liprin-beta1,2_repeat1	357..422	CDD:188962	26/64 (41%)
		SAM	359..423	CDD:197735	26/63 (41%)
		SAM_liprin-beta1,2_repeat2	438..499	CDD:188965	33/60 (55%)
		SAM	439..499	CDD:197735	32/59 (54%)
		SAM_liprin-beta1,2_repeat3	529..600	CDD:188968	43/70 (61%)
		SAM	530..599	CDD:197735	43/68 (63%)
ppfibp1b	NP_001038435.1	DUF16	<105..156	CDD:279814	19/50 (38%)
		DUF342	<202..268	CDD:302792	5/65 (8%)
		SAM	656..720	CDD:197735	26/65 (40%)
		SAM_liprin-beta1,2_repeat1	656..719	CDD:188962	26/64 (41%)
		SAM_liprin-beta1,2_repeat2	730..792	CDD:188965	33/61 (54%)
		SAM	732..792	CDD:197735	32/59 (54%)
		SAM_liprin-beta1,2_repeat3	815..886	CDD:188968	43/70 (61%)
		SAM	817..885	CDD:197735	43/67 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586513
Domainoid	1	1.000	137	1.000	Domainoid score	I4845
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2685
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2050
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	1	1.000	-	-		FOG0002604
OrthoInspector	1	1.000	-	-		otm25681
orthoMCL	1	0.900	-	-		OOG6_104783
Panther	1	1.100	-	-	LDO	PTHR12587
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2993
SonicParanoid	1	1.000	-	-		X1710
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.930