DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-beta and Ppfibp1

DIOPT Version :9

Sequence 1:	NP_001261806.1	Gene:	Liprin-beta / 39524	FlyBaseID:	FBgn0036376	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_008761604.1	Gene:	Ppfibp1 / 312855	RGDID:	1310010	Length:	1032	Species:	Rattus norvegicus

Alignment Length:	985	Identity:	269/985 - (27%)
Similarity:	383/985 - (38%)	Gaps:	367/985 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VAEGSKMLEAALQQMDGLISSTAT----------QAGSVSISGAGSSLTLSERNLISATNVLSTA 58
            :::.|.||.|||:||||:|:.:..          |:.:....|:..:|.|.| :|.....::.|.
  Rat     2 MSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVE-DLRGLLEMMETD 65

  Fly    59 KTLALALQQVGLAAPAPDPVTAAIISDWLET-----HIPRQDS--DERMRRLQRDKEGLALQYQM 116
                   ::.||....||. ||.::.:||:.     |:|....  .||:.||:.|||.|.||..:
  Rat    66 -------EKEGLRCQIPDS-TAEMLIEWLQNQMTNGHLPGNGDVYQERLARLENDKESLVLQVSV 122

  Fly   117 LAERVSEQADKIIELEGLITEKSQQLCTKEEQLQRQMISSSALETQKLELMSALSELKLHRTALE 181
            |.::|..|.:||.:||..:.|..::|...||.||::::|.::|||||||||:.:|.|||..||:|
  Rat   123 LTDQVEAQGEKIRDLEFCLEEHREKLNATEEMLQQELLSRTSLETQKLELMAEISNLKLKLTAVE 187

  Fly   182 ----------------------------------------------------------------- 181

  Rat   188 KDRLDYEDRFRDTEGLIQEINDLRLKVNEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEK 252

  Fly   182 ----------------------------------------------------------------- 181

  Rat   253 QRMEQKWETLKDELASLKEQLEEKECEVKRLQERLVCKTKGEGVEILDRDENIKRKLKEKNIEVQ 317

  Fly   182 ----------------------------------------QANDG-------GSAISANIPYGSL 199
                                                    |..:|       .|:||..:.....
  Rat   318 KMKKAVESLMAANEEKERKIEDLRQCLSRYRKVQDPAALAQGQEGECEGLFHSSSISTLLDAQGF 382

  Fly   200 SNINQKAF----MGSPKTPP-----------SALRHQI--------------------KPQ---- 225
            |::.:...    ||||...|           |.|:..:                    ||:
  Rat   383 SDLERSTSSTPGMGSPSRDPLHTSAPEEFHTSVLQASVPSLFPTSMDEETCEKPKLATKPETSFE 447

  Fly   226 -------------------------------------------------------------FHSL 229
                                                                         |.:|
  Rat   448 EGDGRAVLGADAEVSLSDGVSTSSLQKSSSLGNLKKETSDGVEKESIQKPPEDKTPTDSHTFGTL 512

  Fly   230 P---RSHGKFVNNNNNRALDVNAN--------SSGKQRNVAFASN-------------------- 263
            |   ..||..|:::........::        .|||:  .|.|.|
  Rat   513 PPKAPGHGASVDDSPFGTRKARSSFGRGFFKIKSGKR--TASAPNLDRKRSASAPTLAETEKETD 575

  Fly   264 EHILIDDNHHQAEDAMTSSFMSQFTPSPKLRERSARGLRNILGKLRRSNSSNCELTALEQAEPEF 328
            ||:.:...........||.|... .|||..|::| ||:..:.||||||.|:.  ....:.:||||
  Rat   576 EHLDLAGTSRPKGSQGTSPFQMS-PPSPDSRKKS-RGIMRLFGKLRRSQSTT--FNPDDMSEPEF 636

  Fly   329 RRGGARATAGGRIEWSAQTPLFGENEKHWTT----WGAQEVCNWLAYMGLGCYEDNCRKWLNANP 389
            :|||.|||||.|:.||..   .|::.....|    |..::||:|||..|||.|..:.:.|:.:..
  Rat   637 KRGGTRATAGPRLGWSRD---LGQSNSDLDTPFAKWTKEQVCSWLAEQGLGSYLSSGKHWIMSGQ 698

  Fly   390 SVSFFTASPVDIERELNLKMPLHRKKILLAIDDLTGKEFDDLTLKASSLDVTWVLRWLDDIGLPQ 454
            ::  ..||..|:|:||.:|..|||||:.||:..|..:|    ......||..||.||||||||||
  Rat   699 TL--LQASQQDLEKELGIKHSLHRKKLQLALQALGSEE----ETNYGKLDFNWVTRWLDDIGLPQ 757

  Fly   455 YKDYFMQAKIDGRMLHRLTLEDLSQLHVSSCLHIASLRAGILCMRRLSWNAEGLIRRSIKVVSED 519
            ||..|.:.::||||||.:|::||..|.|.|.||..|::..|..:|..::....|.||     ..|
  Rat   758 YKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLRINNFEPNCLRRR-----PSD 817

  Fly   520 EAAATPDRDNVELWTAHRIMGWLQTIDLSEYTPNLRGAGVHGALMLYEPRFNADLLADLLSIPPS 584
            |.:.||  ..|:.||.||:|.||:::||:||.|||||:||||.||:.|||||.:.:|.||:|||:
  Rat   818 ENSITP--SEVQQWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPN 880

  Fly   585 KSLLRRHLAMHFKELVGRPVILSKRDAESAPGYQPLSITAKLKPVKRT--QFSLKRRKSSKSQSD 647
            |:|||||||.||..|:|......||||...|.|..|:.|||:||.|.|  .|...|:|..:
  Rat   881 KTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKVKPKKLTFSNFGNLRKKKHE---- 941

  Fly   648 VDWTEYVCPM 657
             |..||||||
  Rat   942 -DGEEYVCPM 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-beta	NP_001261806.1	SAM_liprin-beta1,2_repeat1	357..422	CDD:188962	26/68 (38%)
		SAM	359..423	CDD:197735	26/67 (39%)
		SAM_liprin-beta1,2_repeat2	438..499	CDD:188965	33/60 (55%)
		SAM	439..499	CDD:197735	32/59 (54%)
		SAM_liprin-beta1,2_repeat3	529..600	CDD:188968	44/70 (63%)
		SAM	530..599	CDD:197735	44/68 (65%)
Ppfibp1	XP_008761604.1	Smc	<100..>352	CDD:224117	40/251 (16%)
		PHA03307	383..>648	CDD:223039	53/270 (20%)
		SAM_liprin-beta1,2_repeat1	666..729	CDD:188962	25/64 (39%)
		SAM_liprin-beta1,2_repeat2	740..802	CDD:188965	33/61 (54%)
		SAM_liprin-beta1,2_repeat3	825..896	CDD:188968	44/70 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345448
Domainoid	1	1.000	156	1.000	Domainoid score	I4094
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2685
Inparanoid	1	1.050	395	1.000	Inparanoid score	I1901
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	1	1.000	-	-		FOG0002604
OrthoInspector	1	1.000	-	-		otm45540
orthoMCL	1	0.900	-	-		OOG6_104783
Panther	1	1.100	-	-	LDO	PTHR12587
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1710
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900