DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-beta and Liprin-alpha

DIOPT Version :9

Sequence 1:	NP_001261806.1	Gene:	Liprin-beta / 39524	FlyBaseID:	FBgn0036376	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_001260155.1	Gene:	Liprin-alpha / 249072	FlyBaseID:	FBgn0046704	Length:	1214	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	165/727 - (22%)
Similarity:	275/727 - (37%)	Gaps:	172/727 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LQQMDGLI-----SSTATQAGSVSISGAGSSL-----------TLSERNLI---SATNVLSTAKT 60
            :||.:.|.     ||....:|:.|.|.:.:|.           .|||.|.:   .|.......:.
  Fly   531 IQQTEALTRSLSPSSVVDPSGAFSRSNSHASFETHSLRRQSKQRLSEENALVRSMAEQEWEKLQQ 595

  Fly    61 LALALQQVGLAAPAPD----PVTAAIISDWLETHIPRQDSDERMRRLQRDKEGLALQYQMLAERV 121
            .|.|.||....|.|.|    .|..|..:|.:.   |...:|.                |.||..:
  Fly   596 AAHAQQQAYELASAADCDDSDVLYAAATDMMS---PSGHTDA----------------QTLAMML 641

  Fly   122 SEQADKIIELEGLITEKSQQLCTKEEQLQRQMIS---------SSALETQKLELMSALSELKLHR 177
            .||.|.|.....||.|:.|....:.|:|:.::.|         ..:::.|...:....:.....|
  Fly   642 QEQLDAINNEIRLIQEEKQSTEARAEELESRVGSLEHVNLLARGRSMDRQSPPMSGRSTPNSPQR 706

  Fly   178 TALEQANDGGSAISANIP-----------YGSLSNINQKAFMGSPKTPPSALRHQIKPQFHSLPR 231
            ..:::.:      :.|:|           :|.:|.....: .|...:|.:|...:::....:|..
  Fly   707 DFMQKYH------TLNLPVLSSDASREELHGGMSTTGDSS-SGGAASPLTARSMRLERVAQALAH 764

  Fly   232 SHGKFVNNNNNRALDVNANSSGKQRNVA------------------FASNEHILIDDNHHQAEDA 278
            |..:.    ..|::.:|.|:|....:..                  :.|.|.:    .|:   :.
  Fly   765 SQEEL----RRRSIGLNPNASVAPNHTGGHMPLSSHSYGLSPLSSRYGSQESL----RHY---NT 818

  Fly   279 MTSSFMSQFTPSPKLRERSA------RGLRNILGKL--RRSNSSNCELTALEQAEPEFRRGG--- 332
            |.|..|.|...|...||.:|      :|:::.||:.  ::......:.| |....|.....|
  Fly   819 MGSMSMLQTPTSGVSREAAAAAVQKKKGIKSSLGRFFSKKEKVKGVKDT-LPDGSPSMMSIGNLS 882

  Fly   333 -----------ARATAGGRI---------------------EWSAQTPLFGENEKHWT---TWGA 362
                       |.:..||.:                     |...:..|.||..|..|   .|..
  Fly   883 IGLSEVDSNYDAMSMTGGMMPRIASSQGSKISSVDYGRQKKEHDYRNDLLGEAMKAGTPFALWNG 947

  Fly   363 QEVCNWL-AYMGL-GCYEDNCRKWLNANPSVSFFTASPVDIERELNLKMPLHRKKILLAIDDL-- 423
            ..:..|| .::|: ..|...||  .|..........|..:|:||:.:..||||.|:.|||.::
  Fly   948 PTIVAWLELWVGMPAWYVAACR--ANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVS 1010

  Fly   424 ----TGKEFDDLTLKASSLDVTWVLR-WLDDIGLPQYKDYFMQAKIDGRMLHRLTLEDL-SQLHV 482
                :..:....||....::..|:.. ||..:|||||:..||:..:|.|||..||.:|| .||.:
  Fly  1011 LTSPSAPQTSRTTLAFGDMNHEWIGNYWLPGLGLPQYRTTFMECLVDARMLDHLTKKDLRGQLKM 1075

  Fly   483 SSCLHIASLRAGILCMRRLSWNAEGLIRRSIKVVSEDEAAATPDRDNVELWTAHRIMGWLQTIDL 547
            ....|..||:.||..::||:::...|..|  :.:||:...      :|.:|:..|::.|:.:|.|
  Fly  1076 VDSFHRTSLQYGISMLKRLNYDRTELEHR--RKMSENGLC------DVLVWSNERVIRWVGSIGL 1132

  Fly   548 SEYTPNLRGAGVHGALMLYEPRFNADLLADLLSIPPSKSLLRRHLAMHFKELV-----GRPVILS 607
            .||..||..:||||.||..:..|:|:.:...|.||...:..|:.|...|..|:     .||.  :
  Fly  1133 KEYANNLLESGVHGGLMALDEGFDANAMGLALQIPTQNAQARQILDTEFNNLLQIATDRRPE--N 1195

  Fly   608 KRDAESAPGYQP 619
            ::.:.|...|.|
  Fly  1196 EQRSASXCSYSP 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-beta	NP_001261806.1	SAM_liprin-beta1,2_repeat1	357..422	CDD:188962	21/69 (30%)
		SAM	359..423	CDD:197735	20/65 (31%)
		SAM_liprin-beta1,2_repeat2	438..499	CDD:188965	25/62 (40%)
		SAM	439..499	CDD:197735	25/61 (41%)
		SAM_liprin-beta1,2_repeat3	529..600	CDD:188968	24/70 (34%)
		SAM	530..599	CDD:197735	24/68 (35%)
Liprin-alpha	NP_001260155.1	NAT_SF	<26..>106	CDD:302625
		COG1340	35..391	CDD:224259
		Taxilin	250..522	CDD:286771
		SYCE1	279..>404	CDD:291886
		SAM_liprin-alpha1,2,3,4_repeat1	942..1012	CDD:188961	20/71 (28%)
		SAM	942..1008	CDD:197735	20/67 (30%)
		SAM_liprin-alpha1,2,3,4_repeat2	1029..1094	CDD:188964	25/64 (39%)
		SAM	1038..1092	CDD:197735	24/53 (45%)
		SAM_liprin-alpha1,2,3,4_repeat3	1114..1185	CDD:188967	24/70 (34%)
		SAM	1115..1186	CDD:197735	25/70 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D22196at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12587
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950