DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-beta and KAZN

DIOPT Version :9

Sequence 1:	NP_001261806.1	Gene:	Liprin-beta / 39524	FlyBaseID:	FBgn0036376	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_011539376.1	Gene:	KAZN / 23254	HGNCID:	29173	Length:	979	Species:	Homo sapiens

Alignment Length:	781	Identity:	190/781 - (24%)
Similarity:	303/781 - (38%)	Gaps:	194/781 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TVAEGSKMLEAALQQMDGLISSTATQAGSVSISGAGSSLTLSERNLISATNVLSTAKTLALALQQ 67
            ::.|.:|.|  || ::||     |.|:.|..::...:.||.:.|.|...:
Human    98 SMMEDNKQL--AL-RIDG-----AVQSASQEVTNLRAELTATNRRLAELS--------------- 139

  Fly    68 VGLAAPAPDPVTAAIIS---DWLETHI--PRQDSD----ERMRRLQRDKEGLALQYQMLAERVSE 123
             |...|.|.|..||..|   |...|::  |:..:.    |.:.|||.:...|....:|||:.:.|
Human   140 -GGGGPGPGPGAAASASAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEE 203

  Fly   124 ----QADKII---ELEGLITEKSQQLCTKEEQLQRQMISSSALETQKLELMSALSEL-------- 173
                ::.:::   ||...:.:|.|:|...:|.||........|:.:|.:|:|.:.:|
Human   204 SQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESRE 268

  Fly   174 ------------------------------------KLHRTALEQANDGGSAISANIPYGSLSNI 202
                                                :|.|.| ::|.|..:|:.:.:........
Human   269 EQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQA-KEATDHATALRSQLDLKDNRMK 332

  Fly   203 NQKAFMGSPKTPPSALRHQIKPQFHSLPRSHGKFVNNNNNR---ALDVNANSSGKQRNVAF---- 260
            ..:|.:...|...:.|...: |:.|||... |:.|.|.|..   ..|:...::.:|.....
Human   333 ELEAELAMAKQSLATLTKDV-PKRHSLAMP-GETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSH 395

  Fly   261 ----ASNEHILIDDNHHQ----AEDAMTSSFMSQFTP----SPKLRERS----------ARGLRN 303
                |..:.:.:...|.:    ..||..:......||    ||:.|..|          .:.|.|
Human   396 PPHPADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNLHN 460

  Fly   304 IL------------------------------GKLRRS--------NSSNCELT----ALEQAEP 326
            .:                              ||.|:|        :.|.|..|    :|.:.|.
Human   461 PIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSEGEE 525

  Fly   327 EFRRGGARATAGGRIEWSAQTPLFGENEKHWTTWGAQEVCNWL-AYMGLGCYEDNCRKWLNANPS 390
            :..|       ..::|....||:     .||.   |..|..|| ..|.:..|...|.:  |....
Human   526 QMDR-------LQQVELVRTTPM-----SHWK---AGTVQAWLEVVMAMPMYVKACTE--NVKSG 573

  Fly   391 VSFFTASPVDIERELNLKMPLHRKKILLAIDDLTGKEFDDLTLKASSLDVTWVLR-WLDDIGLPQ 454
            ....:.|..|::..|.:...|||:|:.|||:|....|......||:.||..||.: ||:||||.|
Human   574 KVLLSLSDEDLQLGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQ 638

  Fly   455 YKDYFMQAKIDGRMLHRLTLEDLSQ-LHVSSCLHIASLRAGILCMRRLSWNAEGLIRRSIKVVSE 518
            |...|....:|||||:.|...||.: |:||...|..|:..||..:.:::::.|.|
Human   639 YSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREAL---------- 693

  Fly   519 DEAAATPDRDNVE--LWTAHRIMGWLQTIDLSEYTPNLRGAGVHGALMLYEPRFNADLLADLLSI 581
            .|..|..:..|::  :||..|::.|::.|||.||..||..:|||||:::.||.|||:.:|..|.|
Human   694 QERRARCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGI 758

  Fly   582 PPSKSLLRRHLAMHFKELVGRPVILSKRDAE---SAPGYQPLSITAKLKPVKRTQFSLKRRKSSK 643
            |..|.:||||||.....:.........|:||   :.|| :..|:|...|....:....|..:.|.
Human   759 PSGKHILRRHLAEEMSAVFHPANSTGIREAERFGTPPG-RASSVTRAGKEENSSGLKYKAGRVSL 822

  Fly   644 S 644
            |
Human   823 S 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-beta	NP_001261806.1	SAM_liprin-beta1,2_repeat1	357..422	CDD:188962	19/65 (29%)
		SAM	359..423	CDD:197735	18/64 (28%)
		SAM_liprin-beta1,2_repeat2	438..499	CDD:188965	28/62 (45%)
		SAM	439..499	CDD:197735	27/61 (44%)
		SAM_liprin-beta1,2_repeat3	529..600	CDD:188968	33/72 (46%)
		SAM	530..599	CDD:197735	32/70 (46%)
KAZN	XP_011539376.1	TACC	175..350	CDD:282818	31/175 (18%)
		DUF4200	222..335	CDD:290574	17/113 (15%)
		SAM_kazrin_repeat1	541..610	CDD:188963	21/78 (27%)
		SAM	541..608	CDD:197735	21/76 (28%)
		SAM_kazrin_repeat2	620..684	CDD:188966	28/63 (44%)
		SAM	629..683	CDD:197735	24/53 (45%)
		SAM_kazrin_repeat3	706..777	CDD:188969	32/70 (46%)
		SAM	707..766	CDD:197735	26/58 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920