DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Liprin-beta and kazna

DIOPT Version :9

Sequence 1:	NP_001261806.1	Gene:	Liprin-beta / 39524	FlyBaseID:	FBgn0036376	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_021333827.1	Gene:	kazna / 100003663	ZFINID:	ZDB-GENE-081105-97	Length:	814	Species:	Danio rerio

Alignment Length:	737	Identity:	170/737 - (23%)
Similarity:	277/737 - (37%)	Gaps:	190/737 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AALQQMDGLISSTATQAGS------VSISGAGSSLTLSERNLISATNVLSTAKT----------- 60
            :.|:|:..:::....:.|.      :|:|.....||..|:.|..|...|...||
Zfish   105 SVLKQVREMLNRELEETGGGCSVELMSVSQLRVQLTQKEQELDRAKEALQAMKTDRKRLRLERTD 169

  Fly    61 LALALQQVGLAAPAPDPVTAAIISDWLETHIPRQDSDERMRRLQRDKEGLALQYQMLAERVSEQA 125
            |...:||:.....:.:......|.:: |.|  |::|::.:|.|.|:|:.|..:...|..:..|..
Zfish   170 LVNQMQQLYTTLESREEQLRDFIRNY-EQH--RKESEDAVRVLAREKDLLEREKWDLRRQTKEAT 231

  Fly   126 DKIIELEGLITEKSQQLCTKEEQLQRQMISSSALETQKLELMSALSELKLHRTALEQANDGGSAI 190
            :....|...:..|..::    ::|:.::...|:...||||
Zfish   232 EHAGALRSALDLKESRI----KELEAELTMMSSFMAQKLE------------------------- 267

  Fly   191 SANIPYGSLSNINQKAFMGSPKTPPSALRHQIK----------PQFHSLPRSHGKFVNNNNNRA- 244
                         .:.|:.||:.|.|......|          |:.|||.......||.|...|
Zfish   268 -------------SRVFVRSPERPASPKTVSAKQSLATLTKDVPKRHSLAMPTETVVNGNQEWAM 319

  Fly   245 ---LDVNANSSGKQRNVAFASNEHIL---------------------IDDNHHQAEDAMTSSFMS 285
               |.:.|.....|:|:..:.:..:|                     |...|.:....|:.:.:.
Zfish   320 HAELPLTAAIRQSQQNLYHSIDRQVLKASPCVCDGDGISMMSSAAARISPCHSKQASVMSDASVM 384

  Fly   286 Q----FTPSPKLRERS---ARGLRNILGKLRRSNSSNCELTALEQAEPEFRRGGARATAG----- 338
            :    .|||...|.|:   ...|.::..:.||.......|.:|.:.   |.||..|.:..
Zfish   385 EGERSSTPSDSPRHRTHSLCNSLEDLEEQRRRKKKERMGLGSLSRV---FGRGKQRKSMDPTLFD 446

  Fly   339 -------------------------GRIEWSAQTPLFGENEKHWTTWGAQEVCNWL-AYMGLGCY 377
                                     .::|.:...|:        ..|.|..|..|| ..|.:..|
Zfish   447 DSDSLSSPARLSVSLSECEEQLDRLQQVELARSAPM--------CRWRAGTVQAWLEVIMAMPMY 503

  Fly   378 EDNCRKWLNANPSVSFFTASPVDIERELNLKMPLHRKKILLAIDDLTGKEFDDLTLKASSLDVTW 442
            ...|..  |..........:..|:...|.:...:||:|:.|||:|....|......||:.||..|
Zfish   504 MRACAD--NVKSGKVLLVLTDEDLGNVLGISNSMHRRKLRLAIEDYRDAEAGHGLSKAAELDHHW 566

  Fly   443 VLR-WLDDIGLPQYKDYFMQAKIDGRMLHRLTLEDLSQ-LHVSSCLHIASLRAGILCMRRLSWNA 505
            |.: ||.|:|||||..:|....:|||:|..||..||.: ||||...|..||..||..:..|:::.
Zfish   567 VAQAWLTDVGLPQYSQFFHTHLVDGRLLSTLTRADLEKHLHVSKKAHQNSLLLGIQLLHTLNFDK 631

  Fly   506 EGLIRRSIKVVSEDEAAATPDRDNVELWTAHRIMGWLQTIDLSEYTPNLRGAGVHGALMLYEPRF 570
            |.|..|..:..:::...|        :||..||:.|::.|||.|:..||:.:|||||:|:.:|.|
Zfish   632 EILQSRRSECENQNTDPA--------VWTCQRIIKWIKEIDLKEFADNLQTSGVHGAVMVLDPSF 688

  Fly   571 NADLLADLLSIPPSKSLLRRHLAMHFKELV--------------GRPVILSKRD--AESAP---- 615
            .:|.:|..|.||.:|.::|.||:...|.||              |.|..|.::.  :.|:|
Zfish   689 RSDTMATALCIPSNKHMVRHHLSEEMKALVSAARAGLEQEVEPLGTPPTLHRQSSLSSSSPSCHD 753

  Fly   616 ------------GYQPLSITAK 625
                        |..|.::||:
Zfish   754 DQQSLRRVKQQLGLSPKNLTAR 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-beta	NP_001261806.1	SAM_liprin-beta1,2_repeat1	357..422	CDD:188962	17/65 (26%)
		SAM	359..423	CDD:197735	17/64 (27%)
		SAM_liprin-beta1,2_repeat2	438..499	CDD:188965	30/62 (48%)
		SAM	439..499	CDD:197735	29/61 (48%)
		SAM_liprin-beta1,2_repeat3	529..600	CDD:188968	29/70 (41%)
		SAM	530..599	CDD:197735	29/68 (43%)
kazna	XP_021333827.1	SMC_N	67..>269	CDD:330553	36/208 (17%)
		SAM_kazrin_repeat1	482..551	CDD:188963	18/78 (23%)
		SAM_kazrin_repeat2	561..625	CDD:188966	30/63 (48%)
		SAM_kazrin_repeat3	647..718	CDD:188969	30/78 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920