DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps36 and VPS36

DIOPT Version :9

Sequence 1:	NP_648660.1	Gene:	Vps36 / 39523	FlyBaseID:	FBgn0086785	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_013521.3	Gene:	VPS36 / 851135	SGDID:	S000004409	Length:	566	Species:	Saccharomyces cerevisiae

Alignment Length:	519	Identity:	110/519 - (21%)
Similarity:	189/519 - (36%)	Gaps:	156/519 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRFAYVEARLSPNESFVSRDNRVKIYDGDQKTDFEDG--------EVVLTTHRLFWGRP----- 52
            ::..|||    :.:..|::|..|:.::..|..:..|.|        :||.|     |..|
Yeast    71 LDDLAYV----NYSSGFLTRSPRLILFFKDPSSKDELGKSAETASADVVST-----WVCPICMVS 126

  Fly    53 ----GEIARAAV--TLCL----PLSYVI---------SVSEETTASNFFGRKTRIIMHL-----H 93
                ||..:..:  .:|:    |..|.:         ::.......|.||..:..|...     |
Yeast   127 NETQGEFTKDTLPTPICINCGVPADYELTKSSINCSNAIDPNANPQNQFGVNSENICPACTFANH 191

  Fly    94 P------------PTSDKGPGPLD-----TSRATHIKLSGKNGL--SVEFHSALRETLNA----- 134
            |            |.:.|....|:     .|| .||:|. ||.|  :...||||..:.:.
Yeast   192 PQIGNCEICGHRLPNASKVRSKLNRLNFHDSR-VHIELE-KNSLARNKSSHSALSSSSSTGSSTE 254

  Fly   135 -------------------RVWEILLTSE---------IIINGV-----ASS-------PTLEPA 159
                               |..|.:||.:         :.:|||     |||       |.:|
Yeast   255 FVQLSFRKSDGVLFSQATERALENILTEKNKHIFNQNVVSVNGVDMRKGASSHEYNNEVPFIE-- 317

  Fly   160 NDRLARIQKRTGIGGIERHLEAKAKATDENIALAFQDLSVLMAMAKDMVGVSKTISSKIRKQKGE 224
             .:|:||    ||..:|:..|.:....|.....|..||:.||::|..:..:.|..:..::.:...
Yeast   318 -TKLSRI----GISSLEKSRENQLLNNDILFNNALTDLNKLMSLATSIERLYKNSNITMKTKTLN 377

  Fly   225 ISDDETVRFKSYLMSLGIDDPVTRDNFTSNSAYFSSLARQICEMLLDPIEEQGG-----MMSLAD 284
            :.|:.||........|.|.|   |:.|.:...:...:||:|.|..|...::...     :::|.|
Yeast   378 LQDESTVNEPKTRRPLLILD---REKFLNKELFLDEIAREIYEFTLSEFKDLNSDTNYMIITLVD 439

  Fly   285 VYCRVNRAR--GLELLSPEDLLHACEQLSGPIRLRSFPSGARVLQLESHDDALIAVDTLEKVEAA 347
            :|...|::.  |..|:||.::..|||:..        ..|...|:|...:..::.| |.||.:..
Yeast   440 LYAMYNKSMRIGTGLISPMEMREACERFE--------HLGLNELKLVKVNKRILCV-TSEKFDVV 495

  Fly   348 ESLAVEELAKQLGISLLLAKERL------------LVAERL------GKVCRDESVEGLRFYPN 393
            :...|:.:....|..||...:.|            ::.|.|      |.:..|:.:.|:.:|.|
Yeast   496 KEKLVDLIGDNPGSDLLRLTQILSSNNSKSNWTLGILMEVLQNCVDEGDLLIDKQLSGIYYYKN 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps36	NP_648660.1	PH-GRAM-like_Eap45	1..134	CDD:275408	40/188 (21%)
Vps36	NP_648660.1	EAP30	171..382	CDD:282067	51/235 (22%)
VPS36	NP_013521.3	PH-GRAM-like_Vps36	4..122	CDD:275409	13/59 (22%)
		Vps36-NZF-N	109..164	CDD:407195	10/59 (17%)
		RanBP2-type Zn finger	118..146	CDD:275376	5/27 (19%)
		ZnF_RBZ	179..203	CDD:197784	3/23 (13%)
		RanBP2-type Zn finger	181..200	CDD:275376	3/18 (17%)
		EAP30	323..549	CDD:398021	52/241 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346593
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2760
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9374
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004651
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102615
Panther	1	1.100	-	-	LDO	PTHR13128
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1653
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770