DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps36 and vps36

DIOPT Version :9

Sequence 1:	NP_648660.1	Gene:	Vps36 / 39523	FlyBaseID:	FBgn0086785	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001016469.1	Gene:	vps36 / 549223	XenbaseID:	XB-GENE-954399	Length:	387	Species:	Xenopus tropicalis

Alignment Length:	403	Identity:	189/403 - (46%)
Similarity:	263/403 - (65%)	Gaps:	26/403 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRFAYVEARLSPNESFVSRDNRVKIYDGDQKTDFEDGEVVLTTHRLFWGRPGEIARAAVTLCLP 65
            |:||::....|..:|:.|.:...|::.||:.||.|:.|.::||||||.|   .:.......:..|
Frog     1 MDRFSWCTGLLDIDETLVIQQRGVRLSDGEDKTRFDTGTLLLTTHRLIW---RDQKNHDFCIAFP 62

  Fly    66 LSYVISVSEETTASNFFGRKTRIIMHLHPPTSDKGPGPLDTSRATHIKLSGKNGLSVEFHSALRE 130
            ||.::...|:   |...|:..:|::||||||.:|.|||..|||.:::|||.:....:||...|.|
Frog    63 LSQIVFTEEQ---SGGIGKSAKIVVHLHPPTPNKEPGPYQTSRYSYVKLSFREHGQIEFQRRLAE 124

  Fly   131 TLNARVWEILLTSEIIINGVASSPTLE----PANDRLARIQKRTGIGGIERHLEAKAKATDENIA 191
            .|..|.||         ...:|||:::    |...|:    |..||.||||.||.|.|.||:||:
Frog   125 ELTQRRWE---------RSSSSSPSMQITKGPQTGRI----KAVGIVGIERKLEEKRKETDKNIS 176

  Fly   192 LAFQDLSVLMAMAKDMVGVSKTISSKIRKQKGEISDDETVRFKSYLMSLGIDDPVTRDNFTSNSA 256
            .||:|||.||..||:||.:||:|::||:.::|:|::|||:||||||:|:||.:||||:...|.:.
Frog   177 EAFEDLSKLMEKAKEMVELSKSIATKIKDKQGDITEDETIRFKSYLLSMGIANPVTRETHGSGTH 241

  Fly   257 YFSSLARQICEMLLDPIEEQGGMMSLADVYCRVNRARGLELLSPEDLLHAC---EQLSGPIRLRS 318
            |...||:|:..||..|:||:||:|||.:|||.||||||:||||||||::||   |.|..|||||.
Frog   242 YHMQLAKQLAAMLQAPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLESLKLPIRLRV 306

  Fly   319 FPSGARVLQLESHDDALIAVDTLEKVEAAESLAVEELAKQLGISLLLAKERLLVAERLGKVCRDE 383
            |.||..|::.:||::..:....||.|....||..||.||.:|:|:||||||||:||.:|.:|||:
Frog   307 FDSGVMVIEHQSHNEEEMVASALETVSEKGSLTSEEFAKIVGMSVLLAKERLLLAEHMGHLCRDD 371

  Fly   384 SVEGLRFYPNLLL 396
            |||||||||||.|
Frog   372 SVEGLRFYPNLFL 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps36	NP_648660.1	PH-GRAM-like_Eap45	1..134	CDD:275408	48/132 (36%)
Vps36	NP_648660.1	EAP30	171..382	CDD:282067	118/213 (55%)
vps36	NP_001016469.1	PH-GRAM-like_Eap45	1..128	CDD:275408	48/132 (36%)
vps36	NP_001016469.1	EAP30	155..370	CDD:367847	118/214 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2394
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9374
Inparanoid	1	1.050	343	1.000	Inparanoid score	I2285
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D464204at33208
OrthoFinder	1	1.000	-	-		FOG0004651
OrthoInspector	1	1.000	-	-		oto105512
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1653
SonicParanoid	1	1.000	-	-		X4366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090