DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps36 and vps36

DIOPT Version :9

Sequence 1:	NP_648660.1	Gene:	Vps36 / 39523	FlyBaseID:	FBgn0086785	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_596667.1	Gene:	vps36 / 2540981	PomBaseID:	SPBC3B9.09	Length:	467	Species:	Schizosaccharomyces pombe

Alignment Length:	458	Identity:	100/458 - (21%)
Similarity:	167/458 - (36%)	Gaps:	96/458 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LSPNESFVSRDNRVKIYDGDQKT-DFEDGEVVLTTHRLFW---------------------GRPG 53
            |.|:|..:...::|.:|.||:|: ...:|.:.||...:|:                     ....
pombe    15 LDPSEEILLVQDQVGLYFGDEKSFRHNNGTLYLTKKHIFYVDSVDPKKNSLKIKISDIRDVQHTS 79

  Fly    54 EIARAAVTLCLPLSYV-----------ISVSEETTASNFFGRKTRIIMHLHPPTSDK-------- 99
            ...|::..:.|.|.:|           |:|.:........|...|..  :..|.||.
pombe    80 RYFRSSPKIRLSLRHVEKSWACKICTFINVGDPINPCRNCGVANRFT--IIKPKSDARFSQGLCT 142

  Fly   100 ----------------GPGPLDTSRATHIKLSGKNGLSVEFHSALRETLNARVWEILLTSEIIIN 148
                            |....:..|...|:||.:...|.:|:.|::..          |.|  |.
pombe   143 ACTFQNYPDLNTCEICGNQLKNVDRNQLIQLSFRGSGSSKFYEAIKSE----------TDE--IE 195

  Fly   149 GVASSPTLEPANDRLARIQKRTGIGGI---ERHLEAKAKATDENIALAFQDLSVLMAMAKDMVGV 210
            ....|...:....|.|.::|...:|||   |:..|.:.......:..|||||....::|||.:.:
pombe   196 KQRYSNKYDTKVLRKAILEKSLRMGGIHDLEQSHEMQLAKNGRTLVHAFQDLDAFFSLAKDTMSL 260

  Fly   211 SKTISSKIRKQKGEISDDETVRFKSYLMSLGIDDPVTRDNFTSN---SA----YFSSLARQICEM 268
            :...:.|:....|....|:..:..:....||    |.|.|...|   ||    |...|.:.|.|:
pombe   261 ADQFAEKMDGLTGTQQSDKVQQLLNKSNQLG----VLRGNHLDNVPVSANSRLYDIELCKSISEV 321

  Fly   269 LLDPIEEQGGMMSLADVYCRVNRARGLELLSPEDLLHACEQLSG---PIRLRSFPSGARVLQLE- 329
            |...::.....:::...:...||:|...|:.|...:.|||.:..   .|......||..:.||:
pombe   322 LRTRLKADTDTVTMTQAWAIYNRSRKANLIPPTRFVKACELIDSMEVGITTSKMNSGLILFQLKT 386

  Fly   330 -SHDDALIAVDTLEKVEAAESLAVEELAKQLGISLLLAKERLLVAERLGKVCRD---ESVEGLRF 390
             :|...|::. .||.:.  .|....:.|.:|..|:.:..|||..||..|.:.||   ||...|.:
pombe   387 SNHSGKLLSA-ILEVMN--PSTTALKCAMRLHWSIGVTLERLYQAEMDGYIVRDVYEESGSSLLY 448

  Fly   391 YPN 393
            :.|
pombe   449 WKN 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps36	NP_648660.1	PH-GRAM-like_Eap45	1..134	CDD:275408	31/179 (17%)
Vps36	NP_648660.1	EAP30	171..382	CDD:282067	56/225 (25%)
vps36	NP_596667.1	PH-like	2..103	CDD:302622	16/87 (18%)
		Vps36-NZF-N	99..>129	CDD:293593	4/31 (13%)
		RanBP2-type Zn finger	99..119	CDD:275376	2/19 (11%)
		ZnF_RBZ	141..160	CDD:197784	0/18 (0%)
		RanBP2-type Zn finger	141..158	CDD:275376	0/16 (0%)
		EAP30	221..437	CDD:282067	55/222 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	54	1.000	Domainoid score	I3239
eggNOG	1	0.900	-	-		E1_KOG2760
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9374
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004651
OrthoInspector	1	1.000	-	-		oto102129
orthoMCL	1	0.900	-	-		OOG6_102615
Panther	1	1.100	-	-	LDO	PTHR13128
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1653
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.890