DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spt20 and Supt20

DIOPT Version :9

Sequence 1:	NP_001287062.1	Gene:	Spt20 / 39522	FlyBaseID:	FBgn0036374	Length:	1873	Species:	Drosophila melanogaster
Sequence 2:	NP_001344944.1	Gene:	Supt20 / 56790	MGIID:	1929651	Length:	864	Species:	Mus musculus

Alignment Length:	956	Identity:	230/956 - (24%)
Similarity:	355/956 - (37%)	Gaps:	287/956 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 NSNSKPPS-SVCQSGNSKFFNLHEKIRDLYLQLLSNDLNYFAETGLKQRTRSFT--LERLVDREK 344
            ::..:||. ....||....|   :|:.|||::....      |..:||:.|...  ||:||.:|.
Mouse    18 SAQQRPPKRKYLSSGRKSIF---QKLYDLYVEECEK------EPEVKQKLRRNVNLLEKLVMQET 73

  Fly   345 LNTIVVNLYPGNKGYSLALHYDEHMVLNPQTNEWSPTDKDETSSDAAGLGTGTGSHRSRPKPLAQ 409
            |:.:||||||||:||||.|                   :.:..||:
Mouse    74 LSCLVVNLYPGNEGYSLML-------------------RGKNGSDS------------------- 100

  Fly   410 DESQSKTEAGHAKHDFGLVEVLRWPYENDLLLQCIDREMLPEFLMDLLVAETVSLSDGEGTRVYA 474
                               |.:|.|||...||:.:|.|.||..|:|||....|
Mouse   101 -------------------ETIRLPYEEGELLEYLDAEELPPILVDLLEKSQV------------ 134

  Fly   475 KPSVFYAGCVIAQIRDFRQTFATSTNICDMKHILLRPTNATLFAEVQQMGS---QLPAEDKLALE 536
              ::|:.|||||:|||:||:....:.....:|||||||..||..:|..:.|   :...||||.||
Mouse   135 --NIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLVCDVHSITSDNHKWTQEDKLLLE 197

  Fly   537 SQLVLATAEPLCLEPDPSIGRQAINSQHQRQLYNSHELRRQMKKFTQTAINRKRKLDQFTHHHG- 600
            |||:|||||||||:|..::...|....:.||..|:..::|..|:::::::||::.|.     ||
Mouse   198 SQLILATAEPLCLDPSVAVACTANRLLYNRQKMNTRPMKRCWKRYSRSSLNRQQDLS-----HGP 257

  Fly   601 ----LELCDYLARLRQRPRTGSSSGGANATPATAPTNNPLVGAMLSSFTSKVPRRPHEVIRPIRP 661
                |.|.|:|.:.::| :.|                        ..:..|:.:..:.|....|.
Mouse   258 PPPQLRLLDFLQKRKER-KAG------------------------QHYDLKISKAGNCVDMWKRS 297

  Fly   662 PTLEYPANLKVPEHVISVEKYAKAYEPLNEFSEACKDGCQPNC--RHNFQPQLVEEYILETEREA 724
                 |.||.||..| .||||||..|.:.      .|..||..  .|:.:    ::|:.|
Mouse   298 -----PCNLAVPSEV-DVEKYAKVEESIK------SDDSQPTMWPAHDVK----DDYVFE----- 341

  Fly   725 SEGRRALYHIKLSIFQRPSDAEYLGELYVDRDYREGERN------------GESCRFALGTRVHA 777
            .||.......||:|.|...|..|.|::   :.::..|.|            ..|..|.:|::..|
Mouse   342 CEGGNQYQKTKLTILQSLGDPLYYGKI---QPWKADEENDSQMSPSHSSADDHSNWFVIGSKTDA 403

  Fly   778 NRYIQQFREIFTEEGRKAVKITH-------LIPG---------------------HMP----IVT 810
            .|.:.|::|:...|.:..||::|       |.||                     |.|    :.:
Mouse   404 ERVVNQYQELVQNEAKCPVKMSHSSSGSAALSPGEEAEQAETSSIQSSVLGKGVKHRPPPIKLPS 468

  Fly   811 HTGLTNEQRILLQQQQQQQQR--------QAQMQQQQQQQQQQVVVVANQQQQSQQQQQTQQAGQ 867
            .:|.::.......||.....:        :..:.::......||.:::..........|.....:
Mouse   469 GSGNSSSGNYFTAQQASSFLKSPTPPPSCKPSLSRKSSVDLSQVSMLSPAALSPASSSQRSGTPK 533

  Fly   868 QLSATVHHVALPRQQITQKTLNLAGSNVINVQQNFRQQSAQQQQPQTYTIEAPQQQAAAQIVPQQ 932
            ....|....::|.....|.:.....|...:     .|:|....||...|..|.||:|.:|.:|..
Mouse   534 PSPPTPTPSSVPHPPDAQNSAPSTPSATPS-----PQESGFTPQPTLLTQFAQQQRALSQAMPVT 593

  Fly   933 QQQQQQQQQQHIHLQQLATGSSNTSTTTHQVSLSNGSLVLVQQQQPQQQSQQLAQALQH------ 991
            .......      :..:.||||.:........|::.|::         .|...||||:.
Mouse   594 TIPLSTM------VTSITTGSSLSPVMADSAGLTSVSVL---------SSAGGAQALKSGSNSML 643

  Fly   992 ---------------SGI--------TIQPATIQQQQQQ-----VKGTSVVGANSALRAQLNSNV 1028
                           ||:        ...|:.:|...|.     ::.||.:...:.|  ||....
Mouse   644 GCDTGAIPPAGKSLCSGLLPSGGLVANTLPSAVQAAPQAGIPFGLQNTSSLRPLNLL--QLPGGS 706

  Fly  1029 PILQTQLKVQQQQIMQKQQQQQTTATSNNNNNNNNNNNMN----------------NNTAIHPNP 1077
            .|..||.:.||.|:....||.|..|.|.:.......:...                |.|.:...|
Mouse   707 LIFNTQQQQQQTQLPHFIQQPQQPAASGSQQPEEQGSEQGLTAQEQALTAQQAAVINLTGVGGFP 771

  Fly  1078 AINAIVNSIMNSA----------------NQYQQQQQQQHQQQHQQ 1107
            ...|.|.|.:.||                :.:|||||||.|||.||
Mouse   772 QSQAAVLSQLGSAENRPEQSLPQQRLQLSSAFQQQQQQQQQQQQQQ 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt20	NP_001287062.1	Spt20	429..559	CDD:288908	57/132 (43%)
Supt20	NP_001344944.1	Spt20	77..217	CDD:371892	72/210 (34%)
Supt20	NP_001344944.1	Herpes_BLLF1	<480..769	CDD:282904	54/310 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849780
Domainoid	1	1.000	91	1.000	Domainoid score	I7694
eggNOG	1	0.900	-	-		E1_28JPQ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005572
OrthoInspector	1	1.000	-	-		oto94226
orthoMCL	1	0.900	-	-		OOG6_105662
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5049
SonicParanoid	1	1.000	-	-		X4547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.630