Protein Alignment Spt20 and SUPT20H

DIOPT Version :10

• Sequence 1: NP_648659.2
• Gene: Spt20 / 39522
• FlyBaseID: FBgn0036374
• Length: 1873
• Species: Drosophila melanogaster
• Sequence 2: XP_005266504.1
• Gene: SUPT20H / 55578
• HGNCID: 20596
• Length: 859
• Species: Homo sapiens
• Alignment Length: 1023
• Identity: 237/1023 - (23%)
• Similarity: 380/1023 - (37%)
• Gaps: 282/1023 - (27%)

  Fly   283 NSNSKPPS-SVCQSGNSKFFNLHEKIRDLYLQLLSNDLNYFAETGLKQRTRSFT--LERLVDREK 344
            ::..:||. ....||....|   :|:.|||::....      |..:||:.|...  ||:||.:|.
Human    18 SARQRPPKRKYLSSGRKSVF---QKLYDLYIEECEK------EPEVKQKLRRNVNLLEKLVMQET 73

  Fly   345 LNTIVVNLYPGNKGYSLALHYDEHMVLNPQTNEWSPTDKDETSSDAAGLGTGTGSHRSRPKPLAQ 409
            |:.:||||||||:||||.|                   :.:..||:
Human    74 LSCLVVNLYPGNEGYSLML-------------------RGKNGSDS------------------- 100

  Fly   410 DESQSKTEAGHAKHDFGLVEVLRWPYENDLLLQCIDREMLPEFLMDLLVAETVSLSDGEGTRVYA 474
                               |.:|.|||...||:.:|.|.||..|:|||....|
Human   101 -------------------ETIRLPYEEGELLEYLDAEELPPILVDLLEKSQV------------ 134

  Fly   475 KPSVFYAGCVIAQIRDFRQTFATSTNICDMKHILLRPTNATLFAEVQQMGS---QLPAEDKLALE 536
              ::|:.|||||:|||:||:....:.....:|||||||..||..:|..:.|   :...||||.||
Human   135 --NIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLICDVHSITSDNHKWTQEDKLLLE 197

  Fly   537 SQLVLATAEPLCLEPDPSIGRQAINSQHQRQLYNSHELRRQMKKFTQTAINRKRKLDQFTHHHGL 601
            |||:|||||||||:|..::...|....:.:|..|:..::|..|:::::::||::.|........|
Human   198 SQLILATAEPLCLDPSIAVTCTANRLLYNKQKMNTRPMKRCFKRYSRSSLNRQQDLSHCPPPPQL 262

  Fly   602 ELCDYLARLRQRPRTGSSSGGANATPATAPTNNPLVGAMLSSFTSKVPRRPHEVIRPIRPPTLEY 666
            .|.|:|.:.::| :.|                        ..:..|:.:..:.|....|.
Human   263 RLLDFLQKRKER-KAG------------------------QHYDLKISKAGNCVDMWKRS----- 297

  Fly   667 PANLKVPEHVISVEKYAKAYEPLNEFSEACKDGCQPNC--RHNFQPQLVEEYILETEREASEGRR 729
            |.||.:|..| .||||||..:.:.      .|..||..  .|:.:    ::|:.|.|......:
Human   298 PCNLAIPSEV-DVEKYAKVEKSIK------SDDSQPTVWPAHDVK----DDYVFECEAGTQYQK- 350

  Fly   730 ALYHIKLSIFQRPSDAEYLGELYVDRDYREGE---------RNGESCRFALGTRVHANRYIQQFR 785
                .||:|.|...|..|.|::...:...|.:         .:..|..|.:|::..|.|.:.|::
Human   351 ----TKLTILQSLGDPLYYGKIQPCKADEESDSQMSPSHSSTDDHSNWFIIGSKTDAERVVNQYQ 411

  Fly   786 EIFTEEGRKAVKITHLIPGHMPIVTHTGLTNEQRILLQQQQQQQQRQAQMQQQQQQQQQQVVVVA 850
            |:...|.:..||::|...|...:                        :|:...::..|.:.|.|
Human   412 ELVQNEAKCPVKMSHSSSGSASL------------------------SQVSPGKETDQTETVSV- 451

  Fly   851 NQQQQSQQQQQTQQAGQQLSATVHHVALPRQQITQKTLNLAGSNVINVQQNFRQQSAQQQQPQTY 915
                      |:...|:.:......:.||     ..:.|.:..|....||......:....|.:.
Human   452 ----------QSSVLGKGVKHRPPPIKLP-----SSSGNSSSGNYFTPQQTSSFLKSPTPPPSSK 501

  Fly   916 TIEAPQQQAA----------AQIVPQQQQQQQ-----------QQQQQHIHLQQLATGSSNTSTT 959
            ....|::.:.          |.:.|....|:.           .....|....|.:|.|:.::|.
Human   502 PSSIPRKSSVDLNQVSMLSPAALSPASSSQRSGTPKPSTPTPTPSSTPHPPDAQSSTPSTPSATP 566

  Fly   960 THQVSLSNGSLVLVQQQQPQQQSQQLAQALQHSGI-------TIQPAT----IQQQQQQVKGTSV 1013
            |.|.|.......|:.|...||:|  |:||:..:.|       :|.|.|    :......:...:|
Human   567 TPQDSGFTPQPTLLTQFAQQQRS--LSQAMPVTTIPLSTMVTSITPGTTATQVMANSAGLNFINV 629

  Fly  1014 VGANSALRAQLNSNVPILQTQ--------------------LKVQQQQIMQKQQQQQTTATSNNN 1058
            ||:....:|.::.:.|:|...                    |.......||...|.....
Human   630 VGSVCGAQALMSGSNPMLGCNTGAITPAGINLSGLLPSGGLLPNALPSAMQAASQAGVPF----- 689

  Fly  1059 NNNNNNNNMNNNTAIHPNPAINAIVNSIMNSANQYQQQQQQQHQQQHQQQTGNTSSNNNAAGSGG 1123
                   .:.|.:::.|...:.....|::  .|..||||||..|...||....|:.:....|..|
Human   690 -------GLKNTSSLRPLNLLQLPGGSLI--FNTLQQQQQQLSQFTPQQPQQPTTCSPQQPGEQG 745

  Fly  1124 STNNNGSSTSATTLKNSSNASILNL------LNSAPAAMTSTPVASG---------TFTTSTG-- 1171
            |..   .|||.....::..|:::||      :.|..|.::....|..         .|..|:.
Human   746 SEQ---GSTSQEQALSAQQAAVINLTGVGSFMQSQAAVLSQLGSAENRPEQSLPQQRFQLSSAFQ 807

  Fly  1172 --QQQPQTLTLVQHQQQSTPNTADAATATYVQTT---------RGTPT 1208
              |||.|.|..:|||.......|..|...:.:.|         |||||
Human   808 QQQQQIQQLRFLQHQMAMAAAAAQTAQLHHHRHTGSQSKSKMKRGTPT 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spt20	NP_648659.2	Spt20	433..565	CDD:463459	56/134 (42%)
SUPT20H	XP_005266504.1	Spt20	77..214	CDD:463459	72/207 (35%)