DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spt20 and SUPT20H

DIOPT Version :9

Sequence 1:	NP_001287062.1	Gene:	Spt20 / 39522	FlyBaseID:	FBgn0036374	Length:	1873	Species:	Drosophila melanogaster
Sequence 2:	XP_005266504.1	Gene:	SUPT20H / 55578	HGNCID:	20596	Length:	859	Species:	Homo sapiens

Alignment Length:	1023	Identity:	237/1023 - (23%)
Similarity:	380/1023 - (37%)	Gaps:	282/1023 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 NSNSKPPS-SVCQSGNSKFFNLHEKIRDLYLQLLSNDLNYFAETGLKQRTRSFT--LERLVDREK 344
            ::..:||. ....||....|   :|:.|||::....      |..:||:.|...  ||:||.:|.
Human    18 SARQRPPKRKYLSSGRKSVF---QKLYDLYIEECEK------EPEVKQKLRRNVNLLEKLVMQET 73

  Fly   345 LNTIVVNLYPGNKGYSLALHYDEHMVLNPQTNEWSPTDKDETSSDAAGLGTGTGSHRSRPKPLAQ 409
            |:.:||||||||:||||.|                   :.:..||:
Human    74 LSCLVVNLYPGNEGYSLML-------------------RGKNGSDS------------------- 100

  Fly   410 DESQSKTEAGHAKHDFGLVEVLRWPYENDLLLQCIDREMLPEFLMDLLVAETVSLSDGEGTRVYA 474
                               |.:|.|||...||:.:|.|.||..|:|||....|
Human   101 -------------------ETIRLPYEEGELLEYLDAEELPPILVDLLEKSQV------------ 134

  Fly   475 KPSVFYAGCVIAQIRDFRQTFATSTNICDMKHILLRPTNATLFAEVQQMGS---QLPAEDKLALE 536
              ::|:.|||||:|||:||:....:.....:|||||||..||..:|..:.|   :...||||.||
Human   135 --NIFHCGCVIAEIRDYRQSSNMKSPGYQSRHILLRPTMQTLICDVHSITSDNHKWTQEDKLLLE 197

  Fly   537 SQLVLATAEPLCLEPDPSIGRQAINSQHQRQLYNSHELRRQMKKFTQTAINRKRKLDQFTHHHGL 601
            |||:|||||||||:|..::...|....:.:|..|:..::|..|:::::::||::.|........|
Human   198 SQLILATAEPLCLDPSIAVTCTANRLLYNKQKMNTRPMKRCFKRYSRSSLNRQQDLSHCPPPPQL 262

  Fly   602 ELCDYLARLRQRPRTGSSSGGANATPATAPTNNPLVGAMLSSFTSKVPRRPHEVIRPIRPPTLEY 666
            .|.|:|.:.::| :.|                        ..:..|:.:..:.|....|.
Human   263 RLLDFLQKRKER-KAG------------------------QHYDLKISKAGNCVDMWKRS----- 297

  Fly   667 PANLKVPEHVISVEKYAKAYEPLNEFSEACKDGCQPNC--RHNFQPQLVEEYILETEREASEGRR 729
            |.||.:|..| .||||||..:.:.      .|..||..  .|:.:    ::|:.|.|......:
Human   298 PCNLAIPSEV-DVEKYAKVEKSIK------SDDSQPTVWPAHDVK----DDYVFECEAGTQYQK- 350

  Fly   730 ALYHIKLSIFQRPSDAEYLGELYVDRDYREGE---------RNGESCRFALGTRVHANRYIQQFR 785
                .||:|.|...|..|.|::...:...|.:         .:..|..|.:|::..|.|.:.|::
Human   351 ----TKLTILQSLGDPLYYGKIQPCKADEESDSQMSPSHSSTDDHSNWFIIGSKTDAERVVNQYQ 411

  Fly   786 EIFTEEGRKAVKITHLIPGHMPIVTHTGLTNEQRILLQQQQQQQQRQAQMQQQQQQQQQQVVVVA 850
            |:...|.:..||::|...|...:                        :|:...::..|.:.|.|
Human   412 ELVQNEAKCPVKMSHSSSGSASL------------------------SQVSPGKETDQTETVSV- 451

  Fly   851 NQQQQSQQQQQTQQAGQQLSATVHHVALPRQQITQKTLNLAGSNVINVQQNFRQQSAQQQQPQTY 915
                      |:...|:.:......:.||     ..:.|.:..|....||......:....|.:.
Human   452 ----------QSSVLGKGVKHRPPPIKLP-----SSSGNSSSGNYFTPQQTSSFLKSPTPPPSSK 501

  Fly   916 TIEAPQQQAA----------AQIVPQQQQQQQ-----------QQQQQHIHLQQLATGSSNTSTT 959
            ....|::.:.          |.:.|....|:.           .....|....|.:|.|:.::|.
Human   502 PSSIPRKSSVDLNQVSMLSPAALSPASSSQRSGTPKPSTPTPTPSSTPHPPDAQSSTPSTPSATP 566

  Fly   960 THQVSLSNGSLVLVQQQQPQQQSQQLAQALQHSGI-------TIQPAT----IQQQQQQVKGTSV 1013
            |.|.|.......|:.|...||:|  |:||:..:.|       :|.|.|    :......:...:|
Human   567 TPQDSGFTPQPTLLTQFAQQQRS--LSQAMPVTTIPLSTMVTSITPGTTATQVMANSAGLNFINV 629

  Fly  1014 VGANSALRAQLNSNVPILQTQ--------------------LKVQQQQIMQKQQQQQTTATSNNN 1058
            ||:....:|.::.:.|:|...                    |.......||...|.....
Human   630 VGSVCGAQALMSGSNPMLGCNTGAITPAGINLSGLLPSGGLLPNALPSAMQAASQAGVPF----- 689

  Fly  1059 NNNNNNNNMNNNTAIHPNPAINAIVNSIMNSANQYQQQQQQQHQQQHQQQTGNTSSNNNAAGSGG 1123
                   .:.|.:::.|...:.....|::  .|..||||||..|...||....|:.:....|..|
Human   690 -------GLKNTSSLRPLNLLQLPGGSLI--FNTLQQQQQQLSQFTPQQPQQPTTCSPQQPGEQG 745

  Fly  1124 STNNNGSSTSATTLKNSSNASILNL------LNSAPAAMTSTPVASG---------TFTTSTG-- 1171
            |..   .|||.....::..|:::||      :.|..|.::....|..         .|..|:.
Human   746 SEQ---GSTSQEQALSAQQAAVINLTGVGSFMQSQAAVLSQLGSAENRPEQSLPQQRFQLSSAFQ 807

  Fly  1172 --QQQPQTLTLVQHQQQSTPNTADAATATYVQTT---------RGTPT 1208
              |||.|.|..:|||.......|..|...:.:.|         |||||
Human   808 QQQQQIQQLRFLQHQMAMAAAAAQTAQLHHHRHTGSQSKSKMKRGTPT 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spt20	NP_001287062.1	Spt20	429..559	CDD:288908	57/132 (43%)
SUPT20H	XP_005266504.1	Spt20	77..216	CDD:314896	72/209 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159409
Domainoid	1	1.000	91	1.000	Domainoid score	I7677
eggNOG	1	0.900	-	-		E1_28JPQ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3804
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005572
OrthoInspector	1	1.000	-	-		otm41697
orthoMCL	1	0.900	-	-		OOG6_105662
Panther	1	1.100	-	-	LDO	PTHR13526
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5049
SonicParanoid	1	1.000	-	-		X4547
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780