DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tgi and VGLL4

DIOPT Version :9

Sequence 1:	NP_729916.1	Gene:	Tgi / 39521	FlyBaseID:	FBgn0036373	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001121691.1	Gene:	VGLL4 / 9686	HGNCID:	28966	Length:	296	Species:	Homo sapiens

Alignment Length:	244	Identity:	58/244 - (23%)
Similarity:	82/244 - (33%)	Gaps:	103/244 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 PQEEPLPLSLAL--HRTQTPPSPP---------------------------------PSATGSAP 399
            |:.:.||::.||  |||..||..|                                 .:|.|...
Human    36 PRIQTLPVASALSSHRTGPPPISPSKRKFSMEPGDEDLDCDNDHVSKMSRIFNPHLNKTANGDCR 100

  Fly   400 ALPTAVSQ-VMEAAVAGRRILDTPHHTPPRYNTPPPPPPAYGI----------------AGTTVV 447
            ..|...|: .:|.|||....|...|    .|.:    .|:.|:                ||   :
Human   101 RDPRERSRSPIERAVAPTMSLHGSH----LYTS----LPSLGLEQPLALTKNSLDASRPAG---L 154

  Fly   448 APTLTPTPTPNPTPSQIPTPTPS--------MPAIIRVKAEPGLAAVAASSTQTPPASPT----- 499
            :|||||.......||.|...:..        .|.     |..|.||...:|.:.||::.|
Human   155 SPTLTPGERQQNRPSVITCASAGARNCNLSHCPI-----AHSGCAAPGPASYRRPPSAATTCDPV 214

  Fly   500 ------------------SSTNISIFTKTEASVDDHFAKALGETWKKLQ 530
                              :..::||    ..|||||||||||:||.:::
Human   215 VEEHFRRSLGKNYKEPEPAPNSVSI----TGSVDDHFAKALGDTWLQIK 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tgi	NP_729916.1	VGLL4	<258..297	CDD:291898
		TDU	282..297	CDD:197839
		TDU	511..526	CDD:197839	11/14 (79%)
VGLL4	NP_001121691.1	VGLL4	14..230	CDD:291898	43/209 (21%)
VGLL4	NP_001121691.1	TDU	240..255	CDD:197839	11/14 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_110714
Panther	1	1.100	-	-	LDO	PTHR17604
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000