DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Abp1 and Cotl1

DIOPT Version :9

Sequence 1:	NP_648657.1	Gene:	Abp1 / 39520	FlyBaseID:	FBgn0036372	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_082347.1	Gene:	Cotl1 / 72042	MGIID:	1919292	Length:	142	Species:	Mus musculus

Alignment Length:	209	Identity:	53/209 - (25%)
Similarity:	76/209 - (36%)	Gaps:	86/209 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVSFEKNRAQIVAAWKDVLDDKSDTNWSLFGYEGQTNELKVVATGDGGVD------ELNEDLNS 59
            ||...:|...:  ||:..|.||.|...|..|.|:|.|     :..||.|.|      :..:|:.
Mouse     1 MATKIDKEACR--AAYNLVRDDGSAVIWVTFRYDGAT-----IVPGDQGADYQHFIQQCTDDVR- 57

  Fly    60 GKIMYAFVRIE--DPKTGLNKYLLINWQGEGAPVLRKGTCANHIRDVSNLLSGAHLTINARNEDD 122
               ::||||..  |..:..:|:.||.|.||               |||.|
Mouse    58 ---LFAFVRFTTGDAMSKRSKFALITWIGE---------------DVSGL--------------- 89

  Fly   123 IDLDRLLKKLSTVSSAYSFKEPRGAMEEQKAPVGTNYTRVIPTKELNASVMQDFWKKEEAEEKLR 187
                                        |:|..||:.|.|   ||    |:|:|.|:....:  |
Mouse    90 ----------------------------QRAKTGTDKTLV---KE----VVQNFAKEFVISD--R 117

  Fly   188 QEAEKESKRLELQK 201
            :|.|::..|.||:|
Mouse   118 KELEEDFIRSELKK 131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abp1	NP_648657.1	ADF_drebrin_like	3..138	CDD:200437	32/142 (23%)
		DBINO	<173..>207	CDD:290603	10/29 (34%)
		SH3_Abp1_eu	476..529	CDD:212893
Cotl1	NP_082347.1	ADF_coactosin_like	9..120	CDD:200438	44/188 (23%)
Cotl1	NP_082347.1	Flexible and important for F-actin binding. /evidence=ECO:0000250	66..75		1/8 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3655
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810