Protein Alignment Abp1 and HCLS1

DIOPT Version :10

• Sequence 1: NP_648657.1
• Gene: Abp1 / 39520
• FlyBaseID: FBgn0036372
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_005326.3
• Gene: HCLS1 / 3059
• HGNCID: 4844
• Length: 486
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 121/494 - (24%)
• Similarity: 189/494 - (38%)
• Gaps: 99/494 - (20%)

  Fly    76 LNKYLLINWQGEGAPVLRKGTCANHIRDVSNLLSGAHLTINARNEDDIDLDRLLKKL-------- 132
            :|.:.|.|...|...||||          ..:.||...:........::.||:.|..
Human    52 INIHQLRNKVSEEHDVLRK----------KEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAE 106

  Fly   133 -----STVSSAYSFKEPRGAMEEQ--KAPVGTNYTRVIP--TKELNAS--------VMQDFWKKE 180
                 |...:|..|....|...::  |:.||.:|...:.  |.:.:.|        |.:|.|.|.
Human   107 VEKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKA 171

  Fly   181 EAEEKLRQEAEK-ESKRLELQKLEQE---QRSREEKEHKEREKLVISTTKLQPAHVPIKTSPQPL 241
            ......:.|.|| ||:|...:....:   |:.|.:|......::...||..:      ||:|...
Human   172 ALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYK------KTTPIEA 230

  Fly   242 SPEKTAPGFANNLTDAERMRQARNQEARELIGSRVGAAKAMFTKHTSEGQLQSKLNTQPPAKPAR 306
            :...|....|...:.||..|:...:|..:.:..|....||: ||.:.|.. |..:..:.||.||
Human   231 ASSGTRGLKAKFESMAEEKRKREEEEKAQQVARRQQERKAV-TKRSPEAP-QPVIAMEEPAVPA- 292

  Fly   307 NSIAQRINVFNQNQPQDAPVPSPPRAASPAKPLPVEAPEPVVPAPAIAPAAPVAAEVVSTIAEVE 371
             .:.::|:  ::..|   ||.:||.:.|.......|.|.|::|             :..|:.|..
Human   293 -PLPKKIS--SEAWP---PVGTPPSSESEPVRTSREHPVPLLP-------------IRQTLPEDN 338

  Fly   372 ESQPVDDLP------LAHESEQFSTIKRSPHSKSNSLQSQSPDETTSSNETDTAVSQEQEEEVRT 430
            |..|.  ||      |..|.|.....:..|..:      ..|:......:.:.....|||:|...
Human   339 EEPPA--LPPRTLEGLQVEEEPVYEAEPEPEPE------PEPEPENDYEDVEEMDRHEQEDEPEG 395

  Fly   431 KVSVTVQQSQSVKSSGMSTLERNALTDLVNEDDFICQETLG----DLGQRARALYDYQAADETEI 491
            .....::...|..||.::....             |....|    .||..|.|:||||.....|:
Human   396 DYEEVLEPEDSSFSSALAGSSG-------------CPAGAGAGAVALGISAVAVYDYQGEGSDEL 447

  Fly   492 TFDPGDVITHIDQIDEGWWQGLGPDGTYGLFPANYVEII 530
            :|||.||||.|:.:|||||:| ...|.:||||||||:::
Human   448 SFDPDDVITDIEMVDEGWWRG-RCHGHFGLFPANYVKLL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abp1	NP_648657.1	ADF_drebrin_like	3..138	CDD:200437	14/74 (19%)
		SH3_Abp1_eu	476..529	CDD:212893	30/52 (58%)
HCLS1	NP_005326.3	Involved in HAX-1 binding	27..66		4/13 (31%)
		Cortactin 1	79..115		4/35 (11%)
		HS1_rep	82..117	CDD:460497	4/34 (12%)
		Cortactin 2	116..152		8/35 (23%)
		HS1_rep	119..154	CDD:460497	7/34 (21%)
		Cortactin 3	153..189		10/35 (29%)
		HS1_rep	156..191	CDD:460497	10/34 (29%)
		Cortactin 4, truncated	190..212		3/21 (14%)
		HS1_rep	193..>218	CDD:460497	3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..419		44/218 (20%)
		PHA02682	259..>348	CDD:177464	28/112 (25%)
		SH3_HS1	431..485	CDD:213006	30/54 (56%)