DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abp1 and DBNL

DIOPT Version :9

Sequence 1:	NP_648657.1	Gene:	Abp1 / 39520	FlyBaseID:	FBgn0036372	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001116428.1	Gene:	DBNL / 28988	HGNCID:	2696	Length:	439	Species:	Homo sapiens

Alignment Length:	540	Identity:	176/540 - (32%)
Similarity:	265/540 - (49%)	Gaps:	112/540 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVSFEKNRAQIVAAWKDVLDDKSDTNWSLFGYEGQTNELKVVATGDGGVDELNEDLNSGKIMYA 65
            ||.:..:|...:..|:..|:.:||.|:|:||.|||.:|:::|..||:||::|:.|:|||||:|||
Human     1 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYA 65

  Fly    66 FVRIEDPKTGLNKYLLINWQGEGAPVLRKGTCANHIRDVSNLLSGAHLTINARNEDDIDLDRLLK 130
            |.|::||.:||.|::||||.|||...:|||.||:|:..:::.|.|||:|||||.|:|::.:.:::
Human    66 FCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIME 130

  Fly   131 KLSTVSSA-YSFKEPRGAMEE--QKAPVGTNYTRVIPTKELNASVMQDFWKKEEAEEKLRQEAEK 192
            |::..|.| |||.:..|..::  .:||||:.|.:.....|:.......||.|.|.||:.|:..||
Human   131 KVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEK 195

  Fly   193 ESKRLELQKLEQEQRSREEKEHKEREKLVISTTKLQPAHVPIKTSPQPLSPEKTAPGFANNLTDA 257
            .......::||||:|.||.:|...||:      :.|....  :.|||..:.|:.....:.|..:.
Human   196 RRAEEAQRQLEQERRERELREAARREQ------RYQEQGG--EASPQSRTWEQQQEVVSRNRNEQ 252

  Fly   258 ERMRQARNQEA---RELIGSRVGAAKAMFTKHTSEGQLQS----KLNTQPPAKPARNSIAQRINV 315
            .....:..:.|   ||:...:..|...........|:|:|    |..|||.....|
Human   253 GSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR--------- 308

  Fly   316 FNQNQPQDAPVPSPPRAASPAKPLPVEAPEPVVPAPAIAPAAPVAAEVVSTIAEVEESQPVDDLP 380
                  :.|...|.|||..||:.          |||:..|.          :.:.||....::.|
Human   309 ------EPAAAISRPRADLPAEE----------PAPSTPPC----------LVQAEEEAVYEEPP 347

  Fly   381 LAHESEQFSTIKRSPHSKSNSLQSQSPDETTSSNETDTAVSQEQEEEVRTKVSVTVQQSQSVKSS 445
               |.|.|       :.:...:|.|.            |.|:..:..:         |.|.:...
Human   348 ---EQETF-------YEQPPLVQQQG------------AGSEHIDHHI---------QGQGLSGQ 381

  Fly   446 GMSTLERNALTDLVNEDDFICQETLGDLGQRARALYDYQAADETEITFDPGDVITHIDQIDEGWW 510
            |                  :|          |||||||||||:|||:|||.::||.|:.||||||
Human   382 G------------------LC----------ARALYDYQAADDTEISFDPENLITGIEVIDEGWW 418

  Fly   511 QGLGPDGTYGLFPANYVEII 530
            :|.||||.:|:|||||||:|
Human   419 RGYGPDGHFGMFPANYVELI 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abp1	NP_648657.1	ADF_drebrin_like	3..138	CDD:200437	61/134 (46%)
		DBINO	<173..>207	CDD:290603	13/33 (39%)
		SH3_Abp1_eu	476..529	CDD:212893	38/52 (73%)
DBNL	NP_001116428.1	ADF_drebrin_like	3..138	CDD:200437	61/134 (46%)
DBNL	NP_001116428.1	SH3_Abp1_eu	384..437	CDD:212893	39/62 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4739
eggNOG	1	0.900	-	-		E1_KOG3655
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8468
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3408
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55870
OrthoDB	1	1.010	-	-		D535221at33208
OrthoFinder	1	1.000	-	-		FOG0004274
OrthoInspector	1	1.000	-	-		oto90011
orthoMCL	1	0.900	-	-		OOG6_104762
Panther	1	1.100	-	-	LDO	PTHR10829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R73
SonicParanoid	1	1.000	-	-		X2518
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.910