DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Abp1 and STAC3

DIOPT Version :9

Sequence 1:	NP_648657.1	Gene:	Abp1 / 39520	FlyBaseID:	FBgn0036372	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_659501.1	Gene:	STAC3 / 246329	HGNCID:	28423	Length:	364	Species:	Homo sapiens

Alignment Length:	354	Identity:	67/354 - (18%)
Similarity:	120/354 - (33%)	Gaps:	124/354 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 SPQPLSPEKTAPGFANNLTDAERMRQARNQEARELIGSRVGAAKAMFTKHTSEGQLQSKLNTQPP 301
            ||:|..|.:|              ||:..|..::|:  |.|          |.|..:.:|    |
Human     9 SPKPSFPAET--------------RQSGLQRLKQLL--RKG----------STGTKEMEL----P 43

  Fly   302 AKPARNSIAQRIN------VF----NQNQPQDAPVPSPPRAASPAKPLPVEAPEPVVPAPAIAPA 356
            .:|..|..|....      ::    .:.:.::.|.|.||:..:..   |.:..:.....|..
Human    44 PEPQANGEAVGAGGGPIYYIYEEEEEEEEEEEEPPPEPPKLVNDK---PHKFKDHFFKKPKF--- 102

  Fly   357 APVAAEVV---------------------STIAEVEE-------------SQP---------VDD 378
            ..|.|.::                     .:..|::.             |.|         |.|
Human   103 CDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKD 167

  Fly   379 LPLAHESEQ-FSTIK-----RSPHSKSNSLQSQSPDETTSSNETDTAVSQEQEEEVRTKVSVTVQ 437
            |..|:.::. |.|::     .:...|......::|         ..|:.:|:.|..|.:..
Human   168 LSAANRNDPVFETLRTGVIMANKERKKGQADKKNP---------VAAMMEEEPESARPEEG---- 219

  Fly   438 QSQSVKSSGMSTLERNALTDLVNEDDFICQETLGDLGQRAR---ALYDYQAADETEITFDPGDVI 499
            :.|.....|....|:....|...:..|          |::.   |||.::|.::.::.|.||:.|
Human   220 KPQDGNPEGDKKAEKKTPDDKHKQPGF----------QQSHYFVALYRFKALEKDDLDFPPGEKI 274

  Fly   500 THIDQIDEGWWQG-LGPDGTYGLFPANYV 527
            |.||..:|.||:| :|.  ..|.||.|::
Human   275 TVIDDSNEEWWRGKIGE--KVGFFPPNFI 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abp1	NP_648657.1	ADF_drebrin_like	3..138	CDD:200437
		DBINO	<173..>207	CDD:290603
		SH3_Abp1_eu	476..529	CDD:212893	20/56 (36%)
STAC3	NP_659501.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..89		22/112 (20%)
		C1_1	90..135	CDD:278556	3/47 (6%)
		STAC2_u1	147..>239	CDD:293269	17/104 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..244		10/67 (15%)
		SH3_Stac3_1	251..303	CDD:212919	20/53 (38%)
		SH3_Stac_2	310..360	CDD:212768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910