DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stv and BAG3

DIOPT Version :9

Sequence 1:	NP_001097600.1	Gene:	stv / 39518	FlyBaseID:	FBgn0086708	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_004272.2	Gene:	BAG3 / 9531	HGNCID:	939	Length:	575	Species:	Homo sapiens

Alignment Length:	638	Identity:	150/638 - (23%)
Similarity:	239/638 - (37%)	Gaps:	202/638 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 SSLHGPSGQVHAD----DDFPSYFD---DPDFGFPRFSTMGRRGRMAGGANTHMDHDD--DFFN- 176
            ::.|.|..||.:.    |..|..::   ||..|:|.|                :||:.  ..:|
Human     3 AATHSPMMQVASGNGDRDPLPPGWEIKIDPQTGWPFF----------------VDHNSRTTTWND 51

  Fly   177 -RLPSEFRQYIPDGFGG--RRGTGAAPA-----------PGQVP--------QQQQPQP---QPQ 216
             |:|||..:..|....|  |.|:...||           ||.:|        :.:|..|   .||
Human    52 PRVPSEGPKETPSSANGPSREGSRLPPAREGHPVYPQLRPGYIPIPVLHEGAENRQVHPFHVYPQ 116

  Fly   217 YTQQQPQTHFQFGVPPQQQPVYAGPTQQQVPQT--PSKRLCD---AAIQTEDPAG----RSE--- 269
            ...|:.:|......|.:.|....|     :|:|  |.|: |.   ||...:.||.    ||:
Human   117 PGMQRFRTEAAAAAPQRSQSPLRG-----MPETTQPDKQ-CGQVAAAAAAQPPASHGPERSQSPA 175

  Fly   270 -VDCAPP-----------TNLNQHGL-RNTVDMGVKSVAEQDQGLRSHSAPPPEQQQQNLQYHQQ 321
             .||:..           ::|..|.| |..:.:.|    ..:|.:...:|.|...|.|...|..|
Human   176 ASDCSSSSSSASLPSSGRSSLGSHQLPRGYISIPV----IHEQNVTRPAAQPSFHQAQKTHYPAQ 236

  Fly   322 QQQHQ--QPGVHS------QPFGTQTSPP----VQGQQFK---------TYYAP----------- 354
            |.::|  ||..|.      :|...:.:.|    |||...:         ..::|
Human   237 QGEYQTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASSREGSPARSSTPLHSPSPIRVHTVVDR 301

  Fly   355 ------HQQTHP-QQKQQTP-----PPAPQTPGGTYVRTIPIFV---EGRSEPIINAHKEIPNQN 404
                  |::|.| .|.:..|     |..|:.|.|    .|||.|   |..|:|:        :|.
Human   302 PQQPMTHRETAPVSQPENKPESKPGPVGPELPPG----HIPIQVIRKEVDSKPV--------SQK 354

  Fly   405 APPSAQ--------------AQAQAQAYAQAQPQAHAAPQQHNRPTPLNTQAQPEQQVPVEGAAG 455
            .||.::              ..:...:...:.|:: .|.::...|:....:|.|    |..|.|.
Human   355 PPPPSEKVEVKVPPAPVPCPPPSPGPSAVPSSPKS-VATEERAAPSTAPAEATP----PKPGEAE 414

  Fly   456 LPPQTPHTLNSINKIQDIQRDVLELMGKVEQFKGTREEKEYAYLDEMLTRNLLKLDTIDTNGKDS 520
            .||:.|..|    |::.|...|..|...|:.|:|.:.:|:|..::|.||:.||.||::|..|:..
Human   415 APPKHPGVL----KVEAILEKVQGLEQAVDNFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRAD 475

  Fly   521 IRLARKEAIKCIQASINVLEAKAEENARAASGAAPAPS---ATAP---AVDTGAVAASEA---AG 576
            :|.||::.::.:|..:..||.||.:...........||   |..|   .::.|||||.:.   ||
Human   476 VRQARRDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSNLEADQPLQAIMEMGAVAADKGKKNAG 540

  Fly   577 QNAEPVTPQPQDATKMQEPIPLPAPPNAAAVEGAAASEATAAEATQSAVQSET 629
            ...:|       .|:.|:|                  |||||..:..:..::|
Human   541 NAEDP-------HTETQQP------------------EATAAATSNPSSMTDT 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stv	NP_001097600.1	BAG	470..541	CDD:280360	22/70 (31%)
BAG3	NP_004272.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92		24/104 (23%)
		WW	21..53	CDD:197736	9/47 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..200		18/82 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..421		39/197 (20%)
		BAG	421..498	CDD:214591	25/80 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..575		13/62 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158660
Domainoid	1	1.000	63	1.000	Domainoid score	I10260
eggNOG	1	0.900	-	-		E1_KOG4361
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I5210
Isobase	1	0.950	-	0	Normalized mean entropy	S6778
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40524
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12329
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7026
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.960