DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stv and BAG4

DIOPT Version :9

Sequence 1:	NP_001097600.1	Gene:	stv / 39518	FlyBaseID:	FBgn0086708	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_004865.1	Gene:	BAG4 / 9530	HGNCID:	940	Length:	457	Species:	Homo sapiens

Alignment Length:	524	Identity:	132/524 - (25%)
Similarity:	192/524 - (36%)	Gaps:	169/524 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 AGFG--DSRKRSSLHGPSG---QVHADDDFPSYFDDPDFGFPRFSTMGRRGRMAGGANTHMDHDD 172
            :|:|  |.......:||.|   .||...  |.|...|:...|..|     .|:.||.
Human     7 SGYGPSDGPSYGRYYGPGGGDVPVHPPP--PLYPLRPEPPQPPIS-----WRVRGGG-------- 56

  Fly   173 DFFNRLPSEFRQYIPDGFGG---RRGTGAAPAPGQV--PQQQQPQPQPQYTQQ-----------Q 221
                  |:| ..::.:|.||   ....||.|.||:.  ..|:|| |.|.|...           .
Human    57 ------PAE-TTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQP-PYPSYNSNYWNSTARSRAPY 113

  Fly   222 PQTHFQFGVPPQQQ-------------PVY-AGP----------------TQ----QQVPQ---- 248
            |.|   :.|.|:.|             |.| .||                ||    .:||.
Human   114 PST---YPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRS 175

  Fly   249 -----TPSKRL------CDAAIQTEDPAGRSEVDCAPPTNLNQHGLRNTVDMGVKSVAEQDQGLR 302
                 ||..|.      |    |||.|..|.:|...||:.          :.|: ::.....|..
Human   176 SGNSPTPVSRWIYPQQDC----QTEAPPLRGQVPGYPPSQ----------NPGM-TLPHYPYGDG 225

  Fly   303 SHSAPPPEQQQQNLQYHQQQQQHQQPGVHSQ------PFGTQTSPPVQGQQFKTYYAPHQQTHPQ 361
            :.|.|     |.......|:.....||.:..      |....::||  |..:.|     :.|.|.
Human   226 NRSVP-----QSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPP--GNLYMT-----ESTSPW 278

  Fly   362 QKQQTP--PPAP--QTPGGTYVRTIPIFVEGRSEPIINAHKEIPNQNAPPSAQAQAQA------- 415
            ....:|  ||:|  |.|            :..|.|...:.:.:...|.|.|......:
Human   279 PSSGSPQSPPSPPVQQP------------KDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDD 331

  Fly   416 QAYAQAQPQAHAAPQQHNRPT---PLNTQAQ----PEQQVPVEGAAGLPPQTPHTLNSINKIQDI 473
            .....:|.|..|.||.:...|   | |.|.|    ||:.||.:.:.  ||.....::.:.|:|.:
Human   332 SDLLDSQVQYSAEPQLYGNATSDHP-NNQDQSSSLPEECVPSDEST--PPSIKKIIHVLEKVQYL 393

  Fly   474 QRDVLELMGKVEQFKGTREEKEYAYLDEMLTRNLLKLDTIDTNGKDSIRLARKEAIKCIQASINV 538
            :::       ||:|.|.:.:|.|..|:||||:.||:||:::|.|:||:|.|||||:..|||.:..
Human   394 EQE-------VEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEK 451

  Fly   539 LEAK 542
            ||.|
Human   452 LEKK 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stv	NP_001097600.1	BAG	470..541	CDD:280360	30/70 (43%)
BAG4	NP_004865.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..101		32/116 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..136		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..333		40/205 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..378		9/33 (27%)
		BAG	379..456	CDD:214591	33/84 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158661
Domainoid	1	1.000	63	1.000	Domainoid score	I10260
eggNOG	1	0.900	-	-		E1_KOG4361
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008312
OrthoInspector	1	1.000	-	-		otm40524
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12329
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7026
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.960