DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stv and Bag3

DIOPT Version :9

Sequence 1:	NP_001097600.1	Gene:	stv / 39518	FlyBaseID:	FBgn0086708	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_038891.4	Gene:	Bag3 / 29810	MGIID:	1352493	Length:	577	Species:	Mus musculus

Alignment Length:	675	Identity:	161/675 - (23%)
Similarity:	236/675 - (34%)	Gaps:	198/675 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AAGNNVS---PGGPGVNIPVNREYVSGGYGSPQQSAQFHTPQNA----YGSPRQQQQHFQQHQQV 75
            |:||..|   |..||..|.::          ||....|....|:    :..||           |
Mouse    13 ASGNGASDRDPLPPGWEIKID----------PQTGWPFFVDHNSRTTTWNDPR-----------V 56

  Fly    76 PPNQQQQHFQPTFGFEPNMDMDNM---------FPRSHLGRMHDPFAGFGDSRKRSSLHGPSGQV 131
            ||...:.......|  |:.|...:         :|:...|.:..|....|...::..|      .
Mouse    57 PPEGPKDTASSANG--PSRDGSRLLPIREGHPIYPQLRPGYIPIPVLHEGSENRQPHL------F 113

  Fly   132 HADDDFPSYFDDPDFGFPRFSTMGR-----------RGRMAGGANTHMDHDDDFFNRLP------ 179
            ||       :..|  |..||.|...           ||.|...|.|     |....::|
Mouse   114 HA-------YSQP--GVQRFRTEAAAATPQRSQSPLRGGMTEAAQT-----DKQCGQMPATATTA 164

  Fly   180 -----------------------SEFRQYIPDGFGGRRGTGAAPAP-GQVP-----QQQ--QPQP 213
                                   |.....:|.  .||...|:...| |.:|     :|.  :|..
Mouse   165 AAQPPTAHGPERSQSPAASDCSSSSSSASLPS--SGRSSLGSHQLPRGYIPIPVIHEQNITRPAA 227

  Fly   214 QPQYTQQQPQTHF--QFGVPPQQQPVY---AGPTQQQVP---QTPSKRLCDAAIQTEDPAGRS-- 268
            ||.:.|.| :||:  |.|....|||||   .|...:..|   .:|.:.....|...|....||
Mouse   228 QPSFHQAQ-KTHYPAQQGEYQPQQPVYHKIQGDDWEPRPLRAASPFRSPVRGASSREGSPARSGT 291

  Fly   269 EVDCAPPTNLNQHGLRNTVDMGVKSVAEQDQGLRSHSAPPPEQQQQNLQYHQQQQQHQQPGVHSQ 333
            .|.|..|             :.|.:|.::.|.: :|..|||..|.:|       :...:||
Mouse   292 PVHCPSP-------------IRVHTVVDRPQPM-THREPPPVTQPEN-------KPESKPG---- 331

  Fly   334 PFGTQTSP---PVQGQQFKTYYAPHQQTHPQQKQQTPPPAPQTPGGTYVRTIPIFVEGRSEPIIN 395
            |.|....|   |:|..:.:....|       ..|::||||.:           :.|:..|.||
Mouse   332 PAGPDLPPGHIPIQVIRREADSKP-------VSQKSPPPAEK-----------VEVKVSSAPI-- 376

  Fly   396 AHKEIPNQNAPPSAQAQAQAQAYAQAQPQAHAAPQQHNRPTPLNTQAQPEQQVPVEGAAGLPPQT 460
               ..|:.:..||          |...|..:.|.:|...|:|    |..|...|..|.|..||:.
Mouse   377 ---PCPSPSPAPS----------AVPSPPKNVAAEQKAAPSP----APAEPAAPKSGEAETPPKH 424

  Fly   461 PHTLNSINKIQDIQRDVLELMGKVEQFKGTREEKEYAYLDEMLTRNLLKLDTIDTNGKDSIRLAR 525
            |..|    |::.|...|..|...|:.|:|.:.:|:|..::|.||:.||.||::|..|:..:|.||
Mouse   425 PGVL----KVEAILEKVQGLEQAVDSFEGKKTDKKYLMIEEYLTKELLALDSVDPEGRADVRQAR 485

  Fly   526 KEAIKCIQASINVLEAKAEENARAASGAAPAPS---ATAPAVD-TGAVAA--SEAAGQNAEPVTP 584
            ::.::.:|..:..||.||.:...........||   |..|..: .|||.|  .:...:|.:|.|.
Mouse   486 RDGVRKVQTILEKLEQKAIDVPGQVQVYELQPSNLEAEQPLQEIMGAVVADKDKKGPENKDPQTE 550

  Fly   585 QPQDATKMQEPIPLPAPPNAAAVEG 609
            ..|...|...|   |.|.|.|...|
Mouse   551 SQQLEAKAATP---PNPSNPADSAG 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stv	NP_001097600.1	BAG	470..541	CDD:280360	22/70 (31%)
Bag3	NP_038891.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81		20/90 (22%)
		WW	23..55	CDD:197736	8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..207		13/87 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..427		65/260 (25%)
		BAG	426..503	CDD:214591	25/80 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..577		16/52 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849059
Domainoid	1	1.000	63	1.000	Domainoid score	I10203
eggNOG	1	0.900	-	-		E1_KOG4361
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I5085
Isobase	1	0.950	-	0	Normalized mean entropy	S6778
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42596
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12329
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7026
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.960