DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10089 and DUSP16

DIOPT Version :9

Sequence 1:	NP_001261803.1	Gene:	CG10089 / 39517	FlyBaseID:	FBgn0036369	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_085143.1	Gene:	DUSP16 / 80824	HGNCID:	17909	Length:	665	Species:	Homo sapiens

Alignment Length:	449	Identity:	103/449 - (22%)
Similarity:	182/449 - (40%)	Gaps:	96/449 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KVLPGLYVGNYRDSKDHAQLERFKISHII-AIHDSPR-RLLPDKHYLCVMASDTPDQNLSQYFSV 69
            ::||.||:|..||..:...:::..|.::: |.:..|: ..:|:.|:|.|..:|:..:.:..:...
Human   161 RILPNLYLGCQRDVLNKELMQQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDK 225

  Fly    70 CNDFIHAARLREGNVLIHCLAGMSRSVTVAVAYIMTATHLNWKEALKVVRAGRAVANPNAGFQSQ 134
            ..|||..|:...|.||:|||||:|||.|:|:||||....::..||.:.|:..|...:||..|..|
Human   226 SVDFIEKAKASNGCVLVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQ 290

  Fly   135 LQEFEQFKLSEERRRLRERFPSSALEQLDRTKVATALDNYQELLQNRDICEGNCSRGEKCPTGV- 198
            |.::|:    :.:.:.....|.|.|:.|...|....:.         .:.||    |:|..|.:
Human   291 LLDYEK----KIKNQTGASGPKSKLKLLHLEKPNEPVP---------AVSEG----GQKSETPLS 338

  Fly   199 --CNMDPTKGLFRRRPSNAST------------------------H-SRLRAQSSNANASSSSLS 236
              |....|.....:||.:.::                        | |..|.:.||....|.||.
Human   339 PPCADSATSEAAGQRPVHPASVPSVPSVQPSLLEDSPLVQALSGLHLSADRLEDSNKLKRSFSLD 403

  Fly   237 VSSAAAQSCPTSPKNSPLPIVRRSVGNERIPEDEIVLEQPPTT---SREAAEYAAAFEDARREQE 298
            :.|.:..:.           :..|:......||.:...:|.||   :.:..:::...|.:.:..|
Human   404 IKSVSYSAS-----------MAASLHGFSSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPE 457

  Fly   299 QRQLQQQQQLSRSQRSPRPVNSSREAPRVSSAGSRRESAAREGNGSAQLQRSASTVSGFGVRPRS 363
            ....:::..:.:..::.||.:|.         ..|..|.....:|:||               ||
Human   458 TSPDKEEASIPKKLQTARPSDSQ---------SKRLHSVRTSSSGTAQ---------------RS 498

  Fly   364 SPAGLHAYTGSVPSSVH-----GSRVDLRDADKGSAIYL-----GCSAPRASTLSISSS 412
            ..:.||. :|||..:.|     |.....:...|.:.:.|     ...||:.||.|::||
Human   499 LLSPLHR-SGSVEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWHSDILAPQTSTPSLTSS 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10089	NP_001261803.1	DSPc	4..139	CDD:238073	45/133 (34%)
DUSP16	NP_085143.1	DSP_MapKP	10..136	CDD:238723
		DSPc	158..295	CDD:238073	45/133 (34%)
		CDC14	<207..300	CDD:225297	34/96 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..368		9/59 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..505		13/79 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820