DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10089 and Styx

DIOPT Version :9

Sequence 1:	NP_001261803.1	Gene:	CG10089 / 39517	FlyBaseID:	FBgn0036369	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_062611.2	Gene:	Styx / 56291	MGIID:	1891150	Length:	223	Species:	Mus musculus

Alignment Length:	153	Identity:	52/153 - (33%)
Similarity:	82/153 - (53%)	Gaps:	8/153 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNWHMGKVLPGLYVGNYRDSKDHAQ--LERFKISHIIAIHDS--PRRLLPD----KHYLCVMASD 57
            |...|.:|||||::|.|..:.....  |::..|:|||.|..:  ...:.|:    ..||.:..:|
Mouse    25 MRREMQEVLPGLFLGPYSSAMKSKLPILQKHGITHIICIRQNIEANFIKPNFQQLFRYLVLDIAD 89

  Fly    58 TPDQNLSQYFSVCNDFIHAARLREGNVLIHCLAGMSRSVTVAVAYIMTATHLNWKEALKVVRAGR 122
            .|.:|:.::|.:..:||..:....|.||:|..||:|||....:||||....:.:::|...|:..|
Mouse    90 NPVENIIRFFPMTKEFIDGSLQNGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERR 154

  Fly   123 AVANPNAGFQSQLQEFEQFKLSE 145
            ...||||||..||||:|...|::
Mouse   155 FCINPNAGFVHQLQEYEAIYLAK 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10089	NP_001261803.1	DSPc	4..139	CDD:238073	49/142 (35%)
Styx	NP_062611.2	DSP_STYX	25..175	CDD:350372	51/149 (34%)
		Interaction with FBXW7. /evidence=ECO:0000250\|UniProtKB:Q8WUJ0	76..78		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..223
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1042
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850