Protein Alignment CG10089 and SSH1

DIOPT Version :10

• Sequence 1: NP_648654.1
• Gene: CG10089 / 39517
• FlyBaseID: FBgn0036369
• Length: 447
• Species: Drosophila melanogaster
• Sequence 2: XP_011536799.1
• Gene: SSH1 / 54434
• HGNCID: 30579
• Length: 1060
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 123/669 - (18%)
• Similarity: 211/669 - (31%)
• Gaps: 266/669 - (39%)

  Fly    12 LYVGNYRDSKDHAQLERFKISHIIAIHDSPRRLLPD---KHYLCVMASDTPDQNLSQYFSVCNDF 73
            ||:|:..::.:..:|:...:.:|:.:........|.   .|.:.|...:|.|  |..:::....|
Human   327 LYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRVYDEETTD--LLAHWNEAYHF 389

  Fly    74 IHAARLREGNVLIHCLAGMSRSVTVAVAYIMTATHLNW--KEALKVVRAGRAVANPNAGFQSQLQ 136
            |:.|:......|:||..|:|||.:..:||.|  ....|  ::|...|:..|::..|||||..||.
Human   390 INKAKRNHSKCLVHCKMGVSRSASTVIAYAM--KEFGWPLEKAYNYVKQKRSITRPNAGFMRQLS 452

  Fly   137 EFEQF------------------------------------------------------------ 141
            |:|..
Human   453 EYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFLPETPDGTPESQLPFLDDAAQPGLGPP 517

  Fly   142 ------KLSE-------------------ERRRLRE------------RFP-------------- 155
                  :||:                   ||..|.|            |.|
Human   518 LPCCFRRLSDPLLPSPEDETGSLVHLEDPEREALLEEAAPPAEVHRPARQPQQGSGLCEKDVKKK 582

  Fly   156 ---------SSALEQLDRT------------KVATALDNYQELLQNRDICEGNCSRGEKCPTGVC 199
                     |.:|.|::.|            ::.|.||  |.||.:.::   |.:....||.|:
Human   583 LEFGSPKGRSGSLLQVEETEREEGLGAGRWGQLPTQLD--QNLLNSENL---NNNSKRSCPNGM- 641

  Fly   200 NMDPTKGLFRR-RP-------------SNASTHSRLRAQSSNANA---------SSSSLSVSSAA 241
            ..|...|:..: :|             |.|...||.|.:..||.|         ..:|..|:..|
Human   642 EDDAIFGILNKVKPSYKSCADCMYPTASGAPEASRERCEDPNAPAICTQPAFLPHITSSPVAHLA 706

  Fly   242 AQS-CPTSPKNSP------------------------------------------LP---IVRRS 260
            ::| .|..|.:.|                                          ||   :::.|
Human   707 SRSRVPEKPASGPTEPPPFLPPAGSRRADTSGPGAGAALEPPASLLEPSRETPKVLPKSLLLKNS 771

  Fly   261 VGNERIPEDEIVLEQ---PPTTSREAAEYAAAF--EDARREQEQRQLQQQQQLSRSQRSPRPVNS 320
            ..::..|..|:|:::   |....:.|.:....|  |..:.......:|.|:.:.:.|::......
Human   772 HCDKNPPSTEVVIKEESSPKKDMKPAKDLRLLFSNESEKPTTNSYLMQHQESIIQLQKAGLVRKH 836

  Fly   321 SREAPRVSSAGSRRESAAREGNGSAQLQRSASTVSGFGVRPRSSPAGLH--------AYTGS--- 374
            ::|..|:.|..:.....:|:|..| :|:.|....|       ..||.||        :..||
Human   837 TKELERLKSVPADPAPPSRDGPAS-RLEASIPEES-------QDPAALHELGPLVMPSQAGSDEK 893

  Fly   375 ---VPSSVHGS----------RVDLRDADKGSAIYLGCSAPRASTLSISSSRGSSGGSAPPSPCH 426
               .|:|:.|.          |:|...:.....:...|..|.:|::|.:.:|.||..|.
Human   894 SEAAPASLEGGSLKSPPPFFYRLDHTSSFSKDFLKTICYTPTSSSMSSNLTRSSSSDSI------ 952

  Fly   427 TPPASPRHGVKRSTSLVKK 445
                   |.|:....|||:
Human   953 -------HSVRGKPGLVKQ 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10089	NP_648654.1	DSP_DUSP22_15	5..140	CDD:350369	36/132 (27%)
SSH1	XP_011536799.1	SSH-N	41..248	CDD:212166
		DEK_C	262..314	CDD:462592
		DSP_slingshot_1	317..460	CDD:350418	37/136 (27%)
		PTZ00449	<666..1055	CDD:185628	61/320 (19%)