DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10089 and DUSP15

DIOPT Version :9

Sequence 1:	NP_001261803.1	Gene:	CG10089 / 39517	FlyBaseID:	FBgn0036369	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	XP_016883143.1	Gene:	DUSP15 / 128853	HGNCID:	16236	Length:	335	Species:	Homo sapiens

Alignment Length:	383	Identity:	123/383 - (32%)
Similarity:	172/383 - (44%)	Gaps:	90/383 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MGKVLPGLYVGNYRDSKDHAQLERFKISHIIAIHDSPRRLLPDKHYLCVMASDTPDQNLSQYFSV 69
            |.|||||||:||:.|:||..||.|.||:|||:||:||:.||.|..||.:..:|||:..:.::|..
Human     5 MTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKE 69

  Fly    70 CNDFIHAARLREGNVLIHCLAGMSRSVTVAVAYIMTATHLNWKEALKVVRAGRAVANPNAGFQSQ 134
            |.:|||..||..||.|:||.||:|||.|:..||:||.|.|.|::.|:.::|.|.:||||.||:.|
Human    70 CINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQ 134

  Fly   135 LQEFEQFKLSEERRRLRERFPSSALEQLDRTKVATALDNYQE---------------LLQNRDIC 184
            |:||                 ..|..|.|.:..||. |..:|               |||...:.
Human   135 LEEF-----------------GWASSQKDGSGFATE-DEDKEWPHRLAQQGSLLPPILLQALWLT 181

  Fly   185 EGNCSRGEKCPTGVCNMDPTKGLFRRRPSNASTHSRLRAQSSNANASSSSLSVSSAAAQSCPTSP 249
            .|...|..|.....|            |...|....|.|:.:..:|:... ..:...||.|..||
Human   182 TGARHRTSKTSGAQC------------PPMTSATCLLAARVALLSAALVR-EATGRTAQRCRLSP 233

  Fly   250 KNS------PLPIVRRSVGNERIPEDEIVL----EQPPTTSREAAEYAAAFEDARREQEQRQLQQ 304
            :.:      |.|.|  :.|....|:.:|.|    |.|..|.....:...|             ..
Human   234 RAAAERLLGPPPHV--AAGWSPDPKYQICLCFGEEDPGPTQHPKEQLIMA-------------DV 283

  Fly   305 QQQLSRSQRSPRPVNSSREAPRVSSAGSRRESAAREGN--GSAQLQ-------RSAST 353
            |.||       ||.:||   ..:|::..|.:.::..||  |...||       |:||:
Human   284 QVQL-------RPGSSS---CTLSASTERPDGSSTPGNPDGITHLQCSCLHPKRAASS 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10089	NP_001261803.1	DSPc	4..139	CDD:238073	70/133 (53%)
DUSP15	XP_016883143.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	156	1.000	Domainoid score	I4183
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1576308at2759
OrthoFinder	1	1.000	-	-		FOG0002529
OrthoInspector	1	1.000	-	-		otm40470
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1042
SonicParanoid	1	1.000	-	-		X2698
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.910