DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and Gucy2d

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_077356.1	Gene:	Gucy2d / 79222	RGDID:	620438	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1194	Identity:	385/1194 - (32%)
Similarity:	545/1194 - (45%)	Gaps:	267/1194 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PAPAGNYHSGLLHPLLLLLFLL----AFSNFRPTHGEVFTLGYLTASQRRPGNLD----YNRPGL 63
            |.|      ||  |.||||.||    |||       .||.:|.|     .|...|    ..||.|
  Rat    34 PGP------GL--PGLLLLLLLPSPSAFS-------AVFKVGVL-----GPWACDPIFARARPDL 78

  Fly    64 TISGAISLAVEEVNAGRLRDRGHSLQFVVAE----TYGEEVVSIRQTAALWTQQVAAYIGP--QE 122
                |..||.:.:|.....|.|...:..:..    |.|    |:...::..| :|:..:||  ..
  Rat    79 ----AARLATDRLNRDLALDGGPWFEVTLLPEPCLTPG----SLGAVSSALT-RVSGLVGPVNPA 134

  Fly   123 TCVHEGRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQISKSVVALLLAFNWTQVSFLY 187
            .|.....:|....:.::.:.|    |..:|    ...|.|..|..:.::..||.||.|.:|:.:.
  Rat   135 ACRPAELLAQEAGVALVPWGC----PGTRA----AGTTAPAVTPAADALYVLLKAFRWARVALIT 191

  Fly   188 LDD---------------ASGQYQPVA---ETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEA 234
            ...               |.|  .|||   ..:.|.|:.|..::|.||           |.|
  Rat   192 APQDLWVEAGRALSTALRARG--LPVALVTSMVPSDLSGAREALRRIR-----------DGP--- 240

  Fly   235 LVEQTYANTRIYLILGHYY-----EHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRG 294
                   ..|:.:::.|..     |...|:.:.:..| |:.|....:..|...|
  Rat   241 -------RVRVVIMVMHSVLLGGEEQRYLLEAAEELG-LTDGSLVFLPFDTLHY----------- 286

  Fly   295 LLLEDVEPLAV--------QAFQSYLGIV----PTASVSFATFANEVNKYMERPPFNFPNPLGPF 347
            .|....|.||.        :|..:.|.:.    |..||.     :.:.:..|..  ..|..|
  Rat   287 ALSPGPEALAAFVNSSKLRRAHDAVLTLTRRCPPGGSVQ-----DSLRRAQEHQ--ELPLDL--- 341

  Fly   348 GGVKQISAEAAYLYDAVHLYAKALMEVLDS-GGRPRNGSAIVAAIK--------GSRYRSAMGYH 403
             .:||:|.....:||||.|.|..:.....: ||...:|:::...::        |...|:.....
  Rat   342 -DLKQVSPLFGTIYDAVFLLAGGVTRARAAVGGGWVSGASVARQMREAQVFGFCGILGRTEEPSF 405

  Fly   404 VYIDENGDAAGN--YTVLARGSVRNGRNQTVLG-LRPVGTFIHRNSSLSSISKALPHQNLKLFSP 465
            |.:|.  ||||.  :|....        ..||| ||..||.:|           .|.
  Rat   406 VLLDT--DAAGERLFTTHLL--------DPVLGSLRSAGTPVH-----------FPR-------- 441

  Fly   466 IDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKI 530
                |...|...|.|.|..:...|  |.:...:.....||:.:|.|.......|
  Rat   442 ----GAPAPGPDPSCWFDPDVICN--GGVEPGLVFVGFLLVIVVGLTGAFLAHY----------- 489

  Fly   531 DFREVQIHENEREQQSQKQTRHLLNHL-----PRR----------LPPQ--STHPLIRTSQVSLS 578
                               .||.|.|:     |.:          |.||  |:..:.:.|:.||:
  Rat   490 -------------------LRHRLLHMQMVSGPNKIILTLEDVTFLHPQGGSSRKVAQGSRSSLA 535

  Fly   579 SNPDADFRYTTI----FTPIGLYKGQLYAIKKV-RKKSVDITREMKKELKLLRDARHDNICAFIG 638
            :...:|.|....    .|.||||:|....:||. .:..:.|....|.....||:.||:|:..::|
  Rat   536 TRSTSDIRSVPSQPQESTNIGLYEGDWVWLKKFPGEHHMAIRPATKMAFSKLRELRHENVALYLG 600

  Fly   639 ----ACTDPPN------ICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPI 693
                ...|.|.      :.::||:|.||||.|:|...|:|||.||.:|::.|:|:|:.|||...:
  Rat   601 LFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQRDIKLDWMFKSSLLLDLIKGMRYLHHRGV 665

  Fly   694 RFHGALCTSNCLVDSRWVVKLTDFG----LFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQG 754
            . ||.|.:.||:||.|:|:|:||.|    |.|.:...|..|.:.|         |:.||||||.
  Rat   666 A-HGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQ---------LWTAPELLRD- 719

  Fly   755 PSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAF 819
            |:....||..||.:|.||::.|:..|..|:....|||.:.:|:|..|.       |..:||.:..
  Rat   720 PALERRGTLAGDVFSLGIIMQEVVCRSTPYAMLELTPEEVIQRVRSPP-------PLCRPLVSMD 777

  Fly   820 DCVSECLR---ECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRT 881
            ....||::   :||||.||.||.........:.:.||.:.||.|:|:.|:|:|::|||.|:.:||
  Rat   778 QAPMECIQLMAQCWAEHPELRPSMDLTFDLFKGINKGRKTNIIDSMLRMLEQYSSNLEDLIRERT 842

  Fly   882 DQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDF 946
            ::|::||:|||.||.:|||..||:.||.|..|:||::|:|::|||||||||.:||...|::|||.
  Rat   843 EELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDL 907

  Fly   947 LNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRP 1011
            ||||||.||:|||.:||||||||||||||.||||.|||..||||||.|||.:||||..|::||.|
  Rat   908 LNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMP 972

  Fly  1012 TNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLG-G 1075
            ...:.:|||:||||..||||||.|||||||||||||||||||:|:|.:||.:....::|..|. |
  Rat   973 EVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQG 1037

  Fly  1076 YHFAERGVISMKGKGDQRTYWLLG 1099
            :....||...:||||.:.||||:|
  Rat  1038 FQMECRGRTELKGKGVEDTYWLVG 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	96/456 (21%)
		ANF_receptor	67..416	CDD:279440	81/400 (20%)
		PK_GC-A_B	570..853	CDD:270944	100/304 (33%)
		TyrKc	597..847	CDD:197581	91/267 (34%)
		HNOBA	<862..907	CDD:285003	23/44 (52%)
		CYCc	886..1078	CDD:214485	123/192 (64%)
		Guanylate_cyc	913..1099	CDD:278633	118/186 (63%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594	94/453 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..552		6/31 (19%)
		PK_GC-2D	540..814	CDD:270945	97/291 (33%)
		HNOBA	<823..868	CDD:400168	23/44 (52%)
		CYCc	848..1039	CDD:214485	123/190 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1069..1108
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820