DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and Phlpp1

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_038946976.1	Gene:	Phlpp1 / 59265	RGDID:	621308	Length:	1718	Species:	Rattus norvegicus

Alignment Length:	653	Identity:	111/653 - (16%)
Similarity:	185/653 - (28%)	Gaps:	281/653 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   730 STDMQHMSAKCLKLLYRAPELLRQGPS-----------------SLVMGTQRGDAYSFGI----L 773
            |.|:.|::.|        ...|||.||                 ||.:......|:...:    .
  Rat   622 SQDLTHLNLK--------QNFLRQNPSLPAARGLGELQRFTKLKSLNLSNNHLGAFPSAVCSIPT 678

  Fly   774 LYEMHVRRGPFGE--TGLTPMQCLQKVLQPQDYLNPYRPSLQPLE-------------------- 816
            |.|::|......|  ..:..||.||..|...::|......|:.:.
  Rat   679 LAELNVSCNALREVPAAVGAMQNLQTFLLDGNFLQSLPAELENMHQLSYLGLSFNEFTDIPEVLE 743

  Fly   817 --TAFD--CVS-ECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEAL 876
              ||.|  |:: .|:.....:.....|..|.:..:|..|||                       |
  Rat   744 KLTAVDKLCMAGNCMETLRLQALRRMPHIKHVDLRLNILRK-----------------------L 785

  Fly   877 VDDRTDQLQEEKK---------KTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFT 932
            :.|..|.||...:         ..||::.              :.::..|.|:..:...:|.|:
  Rat   786 ITDEVDFLQHVTQLDLRDNKLGDLDAMIF--------------NNIEVLHCERNQLVTLNICGY- 835

  Fly   933 AMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLH 997
                         ||..||...:.:: ..|||.|... .:||.||    ||
  Rat   836 -------------FLKALYASSNELV-QLDVYPVPNY-LSYMDVS----RN-------------- 867

  Fly   998 LLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHC 1062
            .|.:|.|:....|...  :|.|| |: .:|.                           :|.::.|
  Rat   868 CLESVPEWVCESRKLE--VLDIG-HN-QICE---------------------------LPARLFC 901

  Fly  1063 SWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEEARTRRTYERSQRRGSRAL----NK 1123
            :...|:|   |.|::                           |..|..||.:|.....|    |:
  Rat   902 NSSLRKL---LAGHN---------------------------RLARLPERLERTSVEVLDVQHNQ 936

  Fly  1124 FIQ---------GTIKQAQEQANE--------------------YGIRSSLKQK----------- 1148
            .|:         .:::.....||:                    |...:||..|
  Rat   937 IIELPPNLLMKADSLRFLNASANKLETLPPATLSEETSSILQELYLTNNSLTDKCVPLLTGHPRL 1001

  Fly  1149 -----------NLPRNSLTRSSSLE----SPKKLRFAAGSLLEHHRYHS-------DEALLEVDS 1191
                       :.|.:.:.:...||    |..||:....:::...|.|:       .|...||..
  Rat  1002 KILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFPEVMQ 1066

  Fly  1192 YTGLRRSSGGSTQSR----YEETTLSLTLSCQSIEIVGGQHNKRRPSSYP--------TANTPLL 1244
            ...::.:.|..:.||    :......:.|||..:..:      ..|.:.|        |.|..|.
  Rat  1067 LPEVKSTEGNGSLSRSSFLFPLFHQCVDLSCNELSEI------TLPENLPPKLQELDLTGNPRLA 1125

  Fly  1245 MNH 1247
            ::|
  Rat  1126 LDH 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	33/170 (19%)
		TyrKc	597..847	CDD:197581	30/164 (18%)
		HNOBA	<862..907	CDD:285003	7/53 (13%)
		CYCc	886..1078	CDD:214485	35/200 (18%)
		Guanylate_cyc	913..1099	CDD:278633	33/185 (18%)
Phlpp1	XP_038946976.1	Ubiquitin_like_fold	176..>224	CDD:421700
		PHA03247	<237..443	CDD:223021
		RA_PHLPP1	<424..491	CDD:340760
		PH_PHLPP-like	498..594	CDD:270131
		PLN00113	602..>1109	CDD:215061	106/632 (17%)
		leucine-rich repeat	604..624	CDD:275380	1/1 (100%)
		leucine-rich repeat	625..655	CDD:275380	7/37 (19%)
		leucine-rich repeat	679..701	CDD:275380	5/21 (24%)
		leucine-rich repeat	702..724	CDD:275380	5/21 (24%)
		leucine-rich repeat	725..771	CDD:275380	5/45 (11%)
		leucine-rich repeat	772..795	CDD:275380	9/45 (20%)
		leucine-rich repeat	796..816	CDD:275380	2/33 (6%)
		leucine-rich repeat	817..858	CDD:275380	12/55 (22%)
		leucine-rich repeat	859..881	CDD:275380	9/39 (23%)
		leucine-rich repeat	882..904	CDD:275380	7/52 (13%)
		leucine-rich repeat	905..926	CDD:275380	9/50 (18%)
		leucine-rich repeat	927..950	CDD:275380	3/22 (14%)
		leucine-rich repeat	951..974	CDD:275380	2/22 (9%)
		leucine-rich repeat	977..1000	CDD:275380	4/22 (18%)
		leucine-rich repeat	1001..1024	CDD:275380	1/22 (5%)
		leucine-rich repeat	1067..1112	CDD:275380	8/50 (16%)
		PP2Cc	1151..1403	CDD:214625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900