DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and adcy3a

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_009290286.1	Gene:	adcy3a / 571825	ZFINID:	ZDB-GENE-111027-6	Length:	1119	Species:	Danio rerio

Alignment Length:	313	Identity:	94/313 - (30%)
Similarity:	153/313 - (48%)	Gaps:	42/313 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   830 WAERPE--DRPDFKTIRTKLRPLRKGMRPNIFDNMMAM------MEKYANNL---EALVDDRTDQ 883
            |::..:  |...||..|..|.|.:..|...||..|::.      :||.|..|   :..|.::.::
Zfish   791 WSQTFDLYDLTRFKEYRVNLVPSKYTMSVMIFIMMVSFYYFSRHVEKLARTLFLWKIEVHEQKEK 855

  Fly   884 LQEEKKKTDALLHEMLPRCVADQLKKGHKVDPE----HYEQVSIYFSDIVGF----TAMSAECTP 940
            :.|.::..:||:..|||..||.......|.|.|    .|:::.:.|:.|..|    |..|.....
Zfish   856 VYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGG 920

  Fly   941 LQVVDFLNDLYTCFDSIIGHYD---VYKVETIGDAYMVVSGLPLRNGD----------------- 985
            ::.:.|||::.:.|||::....   :.|::|||..||..||:...|..
Zfish   921 IECLRFLNEIISDFDSLLDEPQFRCITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERW 985

  Fly   986 LHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASR 1050
            .|.|::|..:|.:  .|:...|.::..|..:||||::.|.|.|||:|.:.|.:.::|:|||.|||
Zfish   986 QHLADLADFALAM--KVTLMNINYQSFNNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASR 1048

  Fly  1051 MESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEE 1103
            |||:||...|.....|..:|... |:.|..||.|.:||||:..||:|.|.:::
Zfish  1049 MESTGVMGNIQVVEDCYCILKDY-GFRFVRRGPIFVKGKGELLTYFLKGREKQ 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	7/24 (29%)
		TyrKc	597..847	CDD:197581	5/18 (28%)
		HNOBA	<862..907	CDD:285003	14/53 (26%)
		CYCc	886..1078	CDD:214485	66/219 (30%)
		Guanylate_cyc	913..1099	CDD:278633	68/213 (32%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831
		CYCc	273..468	CDD:214485
		Guanylate_cyc	310..492	CDD:278633
		CYCc	858..1075	CDD:214485	66/219 (30%)
		Guanylate_cyc	889..1096	CDD:278633	66/209 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900