DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10738 and adcy7

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_021333246.1	Gene:	adcy7 / 568726	ZFINID:	ZDB-GENE-040713-1	Length:	1119	Species:	Danio rerio

Alignment Length:	428	Identity:	109/428 - (25%)
Similarity:	188/428 - (43%)	Gaps:	84/428 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   853 GMRPNIFDNMM---AMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKG---- 910
            |:...||..::   |:.:.:.:.|..|  ....:|:.||::.:.||..:||..::.::|..
Zfish   189 GIMVGIFHKVLMEKALKQTFQDTLRCL--GIRMKLEIEKRQQENLLQSVLPVYISMKMKLAIMER 251

  Fly   911 ------------------HKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSI 957
                              |.:..:.:|.|||.::||||||.::::|:|.::|..||:|:..||.|
Zfish   252 CKCKDKEEQQRMVRDNNFHSLYVKRHENVSILYADIVGFTRLASDCSPKELVLMLNELFGKFDQI 316

  Fly   958 IGHYDVYKVETIGDAYMVVSGLP--LRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIG 1020
            ....:..:::.:||.|..|||||  |.|   ||.....|.|.:..|:.:  :|......:.:|:|
Zfish   317 AKENECMRIKILGDCYYCVSGLPVSLPN---HAKNCVKMGLDMCEAIKQ--VREATGVDINMRVG 376

  Fly  1021 IHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVIS 1085
            :|||.|..||:||:..::.::...|..|:.|||.|:|.::|.:....:.|::  .|...|
Zfish   377 VHSGNVLCGVIGLRKWQFDVWSHDVTLANHMESGGLPGRVHITEATLKHLNK--AYEVEE----- 434

  Fly  1086 MKGKGDQRTYWL--------LGEDEEARTR----------RTYERSQRRGSRALNKFIQ--GTIK 1130
              |.|..|..:|        |..|..::..          |..:..:.|.|..:.:|::  |.:|
Zfish   435 --GNGHLRDTYLKELNIKTFLVIDPRSKDSSLMAPSITKPRVSDGLKMRASVRMTRFLESWGAVK 497

  Fly  1131 -----QAQEQAN-EYGIRSSLKQKNLPRNSL------TRSSSLESPKKLRFAAGSLLEHHRYHS- 1182
                 |::|:.| :..:......|::|..|:      :...|||.|..|  .|..|..::|..|
Zfish   498 PFAHLQSREEFNTDAMVNGKGHCKDIPLRSVPTHNPDSFDESLEEPFSL--PAPPLSTYNRNKSQ 560

  Fly  1183 ----DEALLEVDSYTGLRRSSGGSTQSRYEETTLSLTL 1216
                ||.|  .|..|........|.|....|....|||
Zfish   561 KTKFDEEL--HDKMTTTINDLSSSKQWVKSEEISGLTL 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	109/428 (25%)
		TyrKc	597..847	CDD:197581
		HNOBA	<862..907	CDD:285003	10/47 (21%)
		CYCc	886..1078	CDD:214485	63/215 (29%)
		Guanylate_cyc	913..1099	CDD:278633	60/195 (31%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	14/60 (23%)
		Guanylate_cyc	272..455	CDD:306677	61/196 (31%)
		DUF1053	487..613	CDD:310728	29/114 (25%)
		Guanylate_cyc	909..1106	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900