DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and adcy2a

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_692173.5	Gene:	adcy2a / 563724	ZFINID:	ZDB-GENE-061109-1	Length:	1155	Species:	Danio rerio

Alignment Length:	416	Identity:	104/416 - (25%)
Similarity:	179/416 - (43%)	Gaps:	93/416 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   883 QLQEEKKKTDALLHEMLPRCVADQLK-------KG------------HKVDPEHYEQVSIYFSDI 928
            :|:.||::.:.||..:||..:|..:|       :|            |.:..:.:..|||.::||
Zfish   291 KLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGPKFGQVENTNNFHNLYVQRHTNVSILYADI 355

  Fly   929 VGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLP--LRNGDLHAAEI 991
            ||||.::::|:|.::|..||:|:..||.|....:..:::.:||.|..|||||  |.|   ||...
Zfish   356 VGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPESLPN---HAKNC 417

  Fly   992 ATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGV 1056
            ..|.|.:..|:.  |:|......:.:|:|:|||.|..||:||:..:|.::...|..|:.||:.||
Zfish   418 VKMGLDMCEAIK--KVRDATGVEISMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGV 480

  Fly  1057 PLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQR----------TYWLLGEDEEA------- 1104
            |.::|.:   .:.|:.|.|.:..|      .|.|.:|          ||.::....|.
Zfish   481 PGRVHIT---SETLEHLNGAYKVE------DGHGQERDPYLKEHGVITYLVINPKVERKSPQHYY 536

  Fly  1105 RTRRTYERSQRRGSRALNKFIQ--------GTIKQAQEQANEYGIRSSLKQKNLPRNSL---TRS 1158
            |.|.|.:.::.|.|..:.::::        ..:.......||.|   .:...::|....   .||
Zfish   537 RPRHTIDGAKMRASVRMTRYLESWGAAKPFANLHHRDSMTNENG---KINTADVPIGQYHFQRRS 598

  Fly  1159 SSLESPKKLRFAAGSLLEHHRYHSDEALLEVDSYTGLRRSSGGSTQSRYEETTLSLTLSCQSIEI 1223
            ...:|.|| ||             :|.|.|    ..:|...|.::|.::        |..:.|:.
Zfish   599 ERTKSQKK-RF-------------EEELNE----RMIRTFDGINSQKQW--------LKSEDIQR 637

  Fly  1224 VG-GQHNKRRPSSYPTANTPLLMNHV 1248
            :. ..|||.....|.....|....::
Zfish   638 ISLFFHNKALEKEYRATTLPAFKYYI 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944
		TyrKc	597..847	CDD:197581
		HNOBA	<862..907	CDD:285003	8/23 (35%)
		CYCc	886..1078	CDD:214485	67/212 (32%)
		Guanylate_cyc	913..1099	CDD:278633	63/197 (32%)
adcy2a	XP_692173.5	AC_N	<92..319	CDD:292831	9/27 (33%)
		CYCc	295..498	CDD:214485	67/210 (32%)
		Guanylate_cyc	340..524	CDD:278633	63/197 (32%)
		DUF1053	554..658	CDD:283888	23/132 (17%)
		CYCc	912..1120	CDD:214485
		Guanylate_cyc	942..1141	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900