DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and adcy5

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	NP_001165056.1	Gene:	adcy5 / 562619	ZFINID:	ZDB-GENE-081104-470	Length:	1186	Species:	Danio rerio

Alignment Length:	303	Identity:	88/303 - (29%)
Similarity:	138/303 - (45%)	Gaps:	63/303 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   857 NIFDN--MMAMMEKYA-NNLEALVDDRTD-----------------------------------Q 883
            ::|||  ::.|....| ||...:||.|..                                   |
Zfish   882 SLFDNVDLLVMANALAPNNGTCIVDTRVPLKIVTPVVITVFVLALYLHAQQVESTARLDFLWKLQ 946

  Fly   884 LQEEKKKTD-------ALLHEMLPRCVADQLKKGHKVDPEHYEQ----VSIYFSDIVGFT----A 933
            ..|||::.:       .|||.:||:.||.......:.:.|.|.|    |::.|:.|..|:    .
Zfish   947 ATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVE 1011

  Fly   934 MSAECTPLQVVDFLNDLYTCFDSIIGH---YDVYKVETIGDAYMVVSGLP----LRNGDLHAAEI 991
            :.|....::.:..||::...||.||..   ..:.|::|||..||..|||.    .:.|..|...:
Zfish  1012 LEANNEGVECLRLLNEIIADFDEIISEDQFRQLEKIKTIGSTYMAASGLNDSTYDKAGRSHIRAL 1076

  Fly   992 ATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGV 1056
            |..::.|:..:.  .|.....|...::||::.|||.|||:|.:.|:|.::|:|||.||||:|:||
Zfish  1077 ADYAMRLMDQMK--YINEHSFNNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGV 1139

  Fly  1057 PLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLG 1099
            |.:|..:....|:|... .|....|||:.:||||:..||:|.|
Zfish  1140 PERIQVTTDLYQVLSSY-NYTLEYRGVVKVKGKGEMMTYFLNG 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944
		TyrKc	597..847	CDD:197581
		HNOBA	<862..907	CDD:285003	18/87 (21%)
		CYCc	886..1078	CDD:214485	66/213 (31%)
		Guanylate_cyc	913..1099	CDD:278633	66/200 (33%)
adcy5	NP_001165056.1	AC_N	1..388	CDD:292831
		CYCc	354..548	CDD:214485
		Guanylate_cyc	390..574	CDD:278633
		DUF1053	598..687	CDD:283888
		CYCc	961..1155	CDD:214485	62/195 (32%)
		Guanylate_cyc	987..1181	CDD:278633	65/196 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810