DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10738 and si:ch211-132f19.7

DIOPT Version :9

Sequence 1:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster
Sequence 2:	XP_688903.4	Gene:	si:ch211-132f19.7 / 560410	ZFINID:	ZDB-GENE-130530-619	Length:	1183	Species:	Danio rerio

Alignment Length:	1346	Identity:	270/1346 - (20%)
Similarity:	437/1346 - (32%)	Gaps:	504/1346 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 SIRQTAALWTQQVAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKADFPTFARTRPPDTQ 166
            ::::...:| |....:|..|....||||   |.|
Zfish    23 NLKRKQLMW-QNAVRHIIDQRGMHHEGR---AVN------------------------------- 52

  Fly   167 ISKSVVALLLAFNWTQVSFLYLDDASGQYQ---------------------PVAE-----TILST 205
             |:.::          |:..|:||.:.|.:                     |..|     |..||
Zfish    53 -SRKII----------VTDAYIDDINRQIRNKAARGNAGMHKRRSSAARIHPFRERNSTCTRKST 106

  Fly   206 --LTDA------GVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTR------------------ 244
              :|||      |.::|.|  :....||.|..:..|.|.:|..:..|
Zfish   107 ESVTDADFFVSWGSTVRGI--FLPALHHKFKSHDLEHLYQQHSSGQRRTSLVVTNVIDILTKLHI 169

  Fly   245 --IYLILGHYY---EH---VGLMVSLQR---------RGILSKGDYFVVGIDIEQYDPAKPEKYL 292
              |||.|....   :|   .||:::|..         :|::|                  |: ||
Zfish   170 IFIYLALAPEMVDSQHGWLAGLLMALGAIICVLVLTCKGLMS------------------PD-YL 215

  Fly   293 R--GL---LLEDVEPL-----AVQAFQSYLGIVPTASVSFATFANEVNKYMERP-PFNFPNPLGP 346
            |  ||   |.:.|:.|     .::..||:.       |.|..||    .|...| |..:...:|
Zfish   216 RYAGLASWLSQTVQALGGLVYGLETDQSWY-------VLFTLFA----IYTLLPLPLLWSICMG- 268

  Fly   347 FGGVKQISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAI--KGSRYRSAMGYHVYIDEN 409
                        :|..|:||:....        :..|.:|||..:  ||..|.......::|...
Zfish   269 ------------FLTAALHLFVDTF--------KNYNDTAIVRKLLAKGLLYMGMNTAGLFIHYL 313

  Fly   410 GDAAGNYTVLARGSVRNGR------NQ----TVLGLRP-------VG----------------TF 441
            .|.|.....|.......||      ||    .|:.:.|       :|                |:
Zfish   314 SDRAQRQAFLETRRCIEGRVKMERENQRQERLVMSILPRFIAMEMIGDMTALDDELLPQQFHKTY 378

  Fly   442 IHRNSSLS----------SISKALPHQNL-----KLFSPIDWV--------------------GG 471
            .|:...:|          |:|..:|.|.|     :||...|.:                    |.
Zfish   379 FHQYKDVSILFADIKGFTSLSMTMPAQELVRTLNELFGRFDRLAEENHCMRIKILGDCYYCVSGV 443

  Fly   472 TRPAAA-PRC----GFGGEKCVNYTG-------EISAAIAGGALL--LLSLVSLVLYRNWRYE-- 520
            ..|..| .||    |......:.|..       ::...|..|::|  :|.|      :.|:::
Zfish   444 PEPQTAHARCCVEMGLAMINTIRYVRKELKRDMDMRIGIHSGSVLCGVLGL------QKWQFDVW 502

  Fly   521 -----------------------QELDSLLWKIDFREVQIHENEREQQSQKQTRHLLNHLPR--R 560
                                   ..||.|....:..|.:.||.....:..|....|:.|.|:  :
Zfish   503 SWDVDVANMLEAGGIPGRIHISRATLDCLEGVYETEEGRGHERNEFLRKHKIDTFLIRHTPQDDK 567

  Fly   561 LPPQSTHPLIRTSQVSLSSNPDADFR-------YTTIFTPIGLYKGQLYAIKKVRKKSVDITREM 618
            .||:    :.|||:...:.:.:..|.       ....||     .|.|..:..........:||:
Zfish   568 EPPK----VRRTSKDETTWSAELPFDNIIGMNCILATFT-----NGSLVHLPNQITPHCAGSREI 623

  Fly   619 KKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSL--KDI-LENEDVKL-DNMFIASMVA 679
            .|.:|...:.|...              .:..|:.|..:|  ||. :|.:..:: |.||.:::..
Zfish   624 NKRIKQAIEVRSSE--------------RMRKEHITPFTLVFKDTHIEGKFSQMRDEMFKSNLAC 674

  Fly   680 DIIRGVIYLHDSPIRFHGALCTSNCLVDS-RWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKL 743
            ..:..:.            :..:..|:.| ::...:..|.:|.|               ...|.|
Zfish   675 SFLLLLF------------IMAAQALIPSPQFFPMIIQFLVFLF---------------VYMLVL 712

  Fly   744 LYRAPELLRQGPSSLV--------------MGTQRGDAYSFGILLYEMHVRRGPFGET------- 787
            |....|..::.|..|.              :.|....|.:||:....:....|.|.||
Zfish   713 LVTLAEEFKRSPPYLQHLCCWIHETKSIRNLLTLTAIAINFGVASCNIFWCNGTFEETEKSNKNS 777

  Fly   788 --------------------GLTPM---------QCLQK------VLQPQDYLNPYRPSLQPLET 817
                                |:..|         .||.|      |:....||         :|.
Zfish   778 EHGKQWPVNICTHPEFFVLSGVVAMVTCAVFLRLSCLLKLAVLTLVIAVYTYL---------IEV 833

  Fly   818 AFDCV-------SECLRECWAERPEDRPDFKTIRTKL------------RPLRKGMRPNIFDNMM 863
            ||..:       |:..|..:..|       |.|...|            |.|....|.:....:.
Zfish   834 AFHVLFIRQHQNSQIQRSQYLRR-------KGISVLLMAMFVVVVLYNSRQLETTSRLDFLWRLQ 891

  Fly   864 AMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVA----DQLKKGHKVDPEHYEQVSIY 924
            |..|         |:|    ::|.::..:.||:.:||..||    ::.:....:..|.||:|.:.
Zfish   892 ARQE---------VED----MKELREHNECLLYNILPAHVARHFLERDRNNEDLFSESYERVGVM 943

  Fly   925 FSDIVGFT---------AMSAECTPLQVVDFLNDLYTCFDSIIGH---YDVYKVETIGDAYMVVS 977
            |:.|.||:         ....||..|     ||::...||.::..   .|:.|::|||..||..|
Zfish   944 FASIPGFSDYYEKKELIHQDVECLRL-----LNEIIADFDELLDEPYFQDIEKIKTIGSCYMAAS 1003

  Fly   978 GLPLRNGDLHA--AEIATMSLHLLSAVSEFK-IRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYC 1039
            ||.....:...  |.::|:.|..|:.....| |..|.:|...||:||..|||.|||:|...|:|.
Zfish  1004 GLSPEKQECEDEWAHLSTLVLFALAMQETLKEINKRTSNDFWLRVGISHGPVVAGVIGATKPQYD 1068

  Fly  1040 LFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKG----KGDQRTYWLLGE 1100
            ::|.|||.||||:|:|:..:|.......::|.. .|:....||.|.:||    :|..|||::...
Zfish  1069 IWGMTVNLASRMDSTGLSGRIQVPEATSRVLAE-HGFMLQLRGEIYVKGVSERRGAVRTYFVSSR 1132

  Fly  1101 DEEARTRRTY-ERSQRRG--------SRALNKFIQGTIKQAQEQAN 1137
            :..:    :| ||:..||        :..:...:|...|:...:||
Zfish  1133 EHNS----SYAERNTSRGISLGRNTLAAVVFSLVQARKKEELREAN 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	85/453 (19%)
		ANF_receptor	67..416	CDD:279440	77/395 (19%)
		PK_GC-A_B	570..853	CDD:270944	60/369 (16%)
		TyrKc	597..847	CDD:197581	51/317 (16%)
		HNOBA	<862..907	CDD:285003	11/48 (23%)
		CYCc	886..1078	CDD:214485	66/210 (31%)
		Guanylate_cyc	913..1099	CDD:278633	68/204 (33%)
si:ch211-132f19.7	XP_688903.4	AC_N	<133..375	CDD:292831	56/292 (19%)
		CYCc	338..537	CDD:214485	32/204 (16%)
		Guanylate_cyc	381..559	CDD:278633	29/183 (16%)
		DUF1053	579..667	CDD:283888	17/106 (16%)
		CYCc	903..1103	CDD:214485	64/205 (31%)
		Guanylate_cyc	932..1131	CDD:278633	68/204 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900