Protein Alignment CG10738 and ADCY10

DIOPT Version :9

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_060887.2
• Gene: ADCY10 / 55811
• HGNCID: 21285
• Length: 1610
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 110/552 - (19%)
• Similarity: 170/552 - (30%)
• Gaps: 221/552 - (40%)

  Fly   674 IASMVADIIRGVIYLHDSPIR-----FHGALC--------------TSNCLVD--SRWVVKLTDF 717
            ||:.:.|:|   :|.|.||.|     |.|.|.              :|...:|  :..:|::.::
Human    16 IAAHLPDLI---VYGHFSPERPFMDYFDGVLMFVDISGFTAMTEKFSSAMYMDRGAEQLVEILNY 77

  Fly   718 GLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVM-------GTQRGDAYSFG---- 771
            .:.|..:.:.....|:...:...|..|:|......:...::|:       |......:..|
Human    78 HISAIVEKVLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSLEIHGLFETQEWEEGLDIR 142

  Fly   772 --ILLYEMHVRRGPFGE----------TGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSE 824
              |.|...|:....||:          ..:..::..|.:.|..|.:      |.|
Human   143 VKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMNDVI------LSP---------- 191

  Fly   825 CLRECW--AERP----EDRPDFKTIRTK-LRPLRKGMRPN-----IFDNMMAMMEKYANNLEALV 877
               .||  .:|.    |..||.:.::.. |:|     .||     .|......|..|.:.
Human   192 ---NCWQLCDRSMIEIESVPDQRAVKVNFLKP-----PPNFNFDEFFTKCTTFMHYYPSG----- 243

  Fly   878 DDRTDQLQEEKK--------KTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAM 934
                    |.|.        |.|..|...|.:.|.:.:.|  ::|   .:|:..|.|
Human   244 --------EHKNLLRLACTLKPDPELEMSLQKYVMESILK--QID---NKQLQGYLS-------- 287

  Fly   935 SAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIG----DAYM-VVSGLPLRNGDL-------- 986
              |..|:.:| |:|.::.         |..|.|.||    |||| :.|.|.:..|.:
Human   288 --ELRPVTIV-FVNLMFE---------DQDKAEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDK 340

  Fly   987 --------------------HAAEIA------TMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGP 1025
                                ||.|.|      ...:|.:..||               ||:.||.
Human   341 GCSFLCVFGFPGEKVPDELTHALECAMDIFDFCSQVHKIQTVS---------------IGVASGI 390

  Fly  1026 VCAGVVGLKM-PRYCLFGDTVNTASRM---------------ESSGVPLKIHCSWQCRQLLDRLG 1074
            |..|:||..: ..|.:.|..||.|:||               ..|.:|
Human   391 VFCGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNLP----------------- 438

  Fly  1075 GYHFAERGVISMKGKGDQ---RTYWLLGEDEE 1103
            .|.|.|.....|||..|.   ..||  |..|:
Human   439 AYFFKELPKKVMKGVADSGPLYQYW--GRTEK 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	41/229 (18%)
		TyrKc	597..847	CDD:197581	39/223 (17%)
		HNOBA	<862..907	CDD:285003	9/52 (17%)
		CYCc	886..1078	CDD:214485	54/254 (21%)
		Guanylate_cyc	913..1099	CDD:278633	54/243 (22%)
ADCY10	NP_060887.2	CHD	40..214	CDD:143636	29/192 (15%)
		AcyC	<42..197	CDD:225025	24/173 (14%)
		CHD	292..461	CDD:143636	46/210 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900