Protein Alignment CG10738 and gucy1a1

DIOPT Version :9

• Sequence 1: NP_729905.2
• Gene: CG10738 / 39516
• FlyBaseID: FBgn0036368
• Length: 1250
• Species: Drosophila melanogaster
• Sequence 2: NP_001296458.1
• Gene: gucy1a1 / 550420
• ZFINID: ZDB-GENE-050417-230
• Length: 679
• Species: Danio rerio
• Alignment Length: 723
• Identity: 191/723 - (26%)
• Similarity: 291/723 - (40%)
• Gaps: 209/723 - (28%)

  Fly   458 QNLKL-----FSPIDWVGGTRPAAAPRCGFGGEKCVNYTGEISAAIAGGALLLLSLVSLVLYRNW 517
            ::||:     ||.:  :|...||     .|.|...||.. .:|..:.|.       ::.:|.|.
Zfish     7 KDLKIAGECPFSMV--LGNEEPA-----DFEGSNAVNVV-PVSREVQGN-------ITNILPRR- 55

  Fly   518 RYEQELDSLLWKIDFREVQIH---ENERE---QQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVS 576
                       ||...:|.:|   |:.|:   .:.:|....|:..:.:::  .::.|:..:|.|
Zfish    56 -----------KISRSKVNLHSLGESVRKLVCPEFEKLRNALIRVIKQQI--DTSCPVACSSDV- 106

  Fly   577 LSSNPDADFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKE----LKLLRDARHDNICAF- 636
             |...|...:.:.:.....|..|......|: ...:::.|:..:|    |:::..|.||.:.:|
Zfish   107 -SHTLDNAEQLSDVMKNYSLKTGIPMDALKI-SLGLEVFRDCYEEDGHILRVVGGALHDFLNSFN 169

  Fly   637 --IGACTDP-PNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDSPIRFHGA 698
              :...|.| |.   |..|..:.|:  :..::|..|..::..:.          |..:.:.|.|.
Zfish   170 VLLKQSTPPTPE---IQRYIHQASI--LCLDKDPGLLTVYFFNP----------LPSTELFFSGI 219

  Fly   699 LCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQG--------- 754
            :..:.||:....|....|.|      |.:..:....|..    .|||..  ::|.|
Zfish   220 IQAAACLLYCTRVEVRMDVG------GKDSGALQADHQP----HLLYSV--VVRDGRSLTPSPMR 272

  Fly   755 -------PSSLVMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYL------- 805
                   |.||:..|     :.|.|||.:         |.||         ||..|.|
Zfish   273 THTSGDIPLSLLYST-----FPFHILLDQ---------EMGL---------LQIGDGLRRRLGRC 314

  Fly   806 --NPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRP---LR-----------KGM 854
              ...||:   ....|..||          ||.|..|:.|.|.|..   ||           .|.
Zfish   315 RDGQRRPA---FNEHFAIVS----------PEIRASFQDILTMLNTQFLLRVKQHGASSADSPGK 366

  Fly   855 RPNIFDNMMAMMEKYA---------NNLE---------------------ALVDDRT-------- 881
            ..::...|:.|.|..|         :.||                     .||.::|
Zfish   367 HMDLKGQMIFMSEMSALLFLGSPCVDKLEELTGRGLYLSDIPIHNALRDVVLVGEQTKAQDGLKK 431

  Fly   882 -------------DQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTA 933
                         ..|:|||::|..||..:.|..||.:|.:|..|..:.::.|::.|||||||||
Zfish   432 RLGKAKAALEQAHQALEEEKRRTVELLFTIFPGNVAQRLWQGLPVQAKKFDHVTVLFSDIVGFTA 496

  Fly   934 MSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHL 998
            :.:.|||:|||:.|::|||.||...|..||||||||||||.|..||. :....||.:||.|:|.:
Zfish   497 ICSRCTPMQVVNMLSELYTRFDHHCGELDVYKVETIGDAYCVAGGLH-KESPTHAVQIALMALKM 560

  Fly   999 LSAVSEFKIRHRPTNRLL-LRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHC 1062
            :....|..   .|...:: :|||||||.|.|||||:|||||||||:.|..|::.||..:|.||:.
Zfish   561 MELSDEVT---TPMGEVIRMRIGIHSGSVLAGVVGVKMPRYCLFGNNVTLANKFESCSLPRKINV 622

  Fly  1063 SWQCRQLL 1070
            |....:||
Zfish   623 SPTTYRLL 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365
		ANF_receptor	67..416	CDD:279440
		PK_GC-A_B	570..853	CDD:270944	66/329 (20%)
		TyrKc	597..847	CDD:197581	58/282 (21%)
		HNOBA	<862..907	CDD:285003	19/95 (20%)
		CYCc	886..1078	CDD:214485	90/186 (48%)
		Guanylate_cyc	913..1099	CDD:278633	79/159 (50%)
gucy1a1	NP_001296458.1	HNOBA	279..470	CDD:285003	49/226 (22%)
		CYCc	449..635	CDD:214485	90/186 (48%)
		Guanylate_cyc	476..647	CDD:278633	79/159 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810